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RESEARCH PAPER · Biomaterials · 2003

Layered double hydroxide as an efficient drug reservoir for folate derivatives

Jin‐Ho Choy, Jisun Jung, Jae‐Min Oh, Man Park, Jinyoung Jeong, Young-Koo Kang, Ok-Jin Han

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Layered double hydroxide as an efficient drug reservoir for folate derivativesOriginalLDH-DNA Nanohybrids: a complete biophysical characterization1Nanoscale Layered Double Hydroxide Materials with Organic Anions Intercalation0Novel layered pesticide slow/controlled release materials -- supramolecular structure and slow release property of glyphosate intercalated layered double hydroxides24Study on the supramolecular structure of sorbic acid inter-calated Zn-Al layered double hydroxides and its thermal decomposition13Synthesis and properties of Mg2Al layered double hydroxides containing 5-fluorouracil121Immobilization of Ibuprofen and Copper-Ibuprofen Drugs on Layered Double Hydroxides106Adsorption and intercalation of anionic surfactants onto layered double hydroxides—XRD study58Intercalation of Natural Cyclodextrins into Layered Double Hydroxide by Calcination–Rehydration Reaction20Nano/Microporous Materials: Nanostructured Layered Double Hydroxides0Applications of Layered Double Hydroxides430Selective anion-exchange intercalation of isomeric benzoate anions into the layered double hydroxide [LiAl2(OH)6]Cl·H2O13In Situ Polymerization and Intercalation of Polymers in Layered Double Hydroxides61Preparation and characterization of a new layered double hydroxide, Co–Zr–Si15Towards understanding, control and application of layered double hydroxide chemistry582Ultrasound-mediated release of [Ru(bpy) 3 ] 2+ from a layered titanate film—a model for controlled drug release from layered metal oxide films3Synthesis and adsorption properties of p-sulfonated calix[4 and 6]arene-intercalated layered double hydroxides45Efficient delivery of anticancer drug MTX through MTX-LDH nanohybrid system165Intracrystalline structure of DNA molecules stabilized in the layered double hydroxide76Intercalation of amino acids and oligopeptides into Zn–Al layered double hydroxide by coprecipitation reaction80Intercalation of dipeptides during V2O5.nH2O xerogel condensation12Biological Hybrid Materials for Drug Delivery System8Experimental Investigations of Amino Acid-Layered Double Hydroxide Complexes: Glutamate−Hydrotalcite57The dynamic process in the formation of Tyr/LDH nanohybrids16Applications of Layered Double Hydroxides205Biocompatible protoporphyrin IX-containing nanohybrids with potential applications in photodynamic therapy19Intercalation of hydrophilic and hydrophobic antibiotics in layered double hydroxides118Nanoceramics-Biomolecular Conjugates for Gene and Drug Delivery7Intercalation behavior of l-ascorbic acid into layered double hydroxides80Cellular Uptake Mechanism of an Inorganic Nanovehicle and Its Drug Conjugates: Enhanced Efficacy Due To Clathrin-Mediated Endocytosis254One-pot synthetic route to polymer–silica assembled capsule encased with nonionic drug molecule26Clay minerals and layered double hydroxides for novel biological applications623New Inorganic-Based Drug Delivery System of Indole-3-Acetic Acid-Layered Metal Hydroxide Nanohybrids with Controlled Release Rate244The construction and characterization of layered double hydroxides as delivery vehicles for podophyllotoxins20Laponite-based nanohybrid for enhanced solubility and controlled release of itraconazole121Preparation and characterization of a new nano layered material, Co–Zr LDH25Ceramic nanovector based on layered double hydroxide: attributes, physiologically relevant compositions and surface activation12Itraconazole–Laponite: Kinetics and mechanism of drug release103Human-related application and nanotoxicology of inorganic particles: complementary aspects110Preparation of a new nano-layered materials and organic–inorganic nano-hybrid materials, Zn–Si LDH26Anticancer drug-layered hydroxide nanohybrids as potent cancer chemotherapy agents97Bio‐Inorganic Conjugates for Drug and Gene Delivery7Development of controlled drug release formulation based on pamoate-zinc-aluminium-layered double hydroxide nano composite5Preparation of titanate coated magnetite powder for cisplatin delivery6Synthesis of unusual coral-like layered double hydroxide microspheres in a nonaqueous polar solvent/surfactant system72Insertion of chromium(III) ascorbate complex into layered double hydroxide through reduction of intercalated chromate by ascorbic acid18水溶性铑膦配合物插层水滑石的制备及主、客体组成对其催化性能的影响0Gene and Drug Delivery System with Soluble Inorganic Carriers6Direct Control of Drug Release Behavior from Layered Double Hydroxides through Particle Interactions81Preparation and intercalation reactions of nano-structural materials, Zn–Al–Ti LDH56LDH Nanocomposites with Different Guest Entities as Precursors of Supported Ni Catalysts60Preparation of Rh-TPPTS complex intercalated layered double hydroxide and influences of host and guest compositions on its catalytic performances in hydroformylation reaction10Subcellular compartment targeting of layered double hydroxide nanoparticles279Two different approaches to synthesizing Mg–Al-layered double hydroxides as folic acid carriers42Surface charging of layered double hydroxides during dynamic interactions of anions at the interfaces147In Situ Polymerization of the 4-Vinylbenzenesulfonic Anion in Ni−Al−Layered Double Hydroxide and Its Molecular Dynamic Simulation36Spontaneous Magnetization in Ni−Al and Ni−Fe Layered Double Hydroxides89Inorganic Metal Hydroxide Nanoparticles for Targeted Cellular Uptake Through Clathrin‐Mediated Endocytosis197Synthesis and Crystal Structures of New Lanthanide Hydroxyhalide Anion Exchange Materials, Ln2(OH)5X·1.5H2O (X = Cl, Br; Ln = Y, Dy, Er, Yb)138Simplified synthesis of layered double hydroxide using a natural source of magnesium33Biocompatible ceramic nanocarrier for drug delivery with high efficiency43Controlled synthesis of layered double hydroxide compounds with novel morphologies for biological applications0Layered nanomaterials for green materials215Toxicological effects of inorganic nanoparticles on human lung cancer A549 cells251Preparation, characterization, and anti-tumor property of podophyllotoxin-loaded solid lipid nanoparticles52Inorganic Drug‐Delivery Nanovehicle Conjugated with Cancer‐Cell‐Specific Ligand200Poly( L ‐lactic acid) nanocomposites with layered double hydroxides functionalized with ibuprofen56Inorganic layered double hydroxides as ascorbic acid (vitamin C) delivery system—Intercalation and their controlled release properties100New Layered Double Hydroxides/Phospholipid Bilayer Hybrid Material with Strong Potential for Sustained Drug Delivery System63Detection of Biocompatibility between Nano-Layered Double Hydroxides and Hela Cells2Synthesis, Characterization, and Magnetically Controlled Release Behavior of Novel Core−Shell Structural Magnetic Ibuprofen-Intercalated LDH Nanohybrids101Synthesis and release behavior of bactericides intercalated Mg–Al layered double hydroxides40Synthesis and characterization of ibuprofen-rectorite composites by solution intercalation method5Synthesis of composites of sodium oleate/Mg–Al-ascorbic acid-layered double hydroxides for drug delivery applications36Layered double hydroxide nanoparticles in gene and drug delivery284Lanthanide-Doped Layered Double Hydroxides Intercalated with Sensitizing Anions: Efficient Energy Transfer between Host and Guest Layers83Hybridization of the natural antibiotic, cinnamic acid, with layered double hydroxides (LDH) as green pesticide52In-Vitro Release Kinetics and Stability of Anticardiovascular Drugs-Intercalated Layered Double Hydroxide Nanohybrids68Signalling pathways involved in the activation of dendritic cells by layered double hydroxide nanoparticles72Efficient siRNA delivery to mammalian cells using layered double hydroxide nanoparticles188Fluorescent layered double hydroxide nanoparticles for biological studies56Controlled preparation of layered double hydroxide nanoparticles and their application as gene delivery vehicles116Layered double hydroxide as novel antibacterial drug delivery system124Synthesis and Characterization of Dual Radiolabeled Layered Double Hydroxide Nanoparticles for Use in In Vitro and In Vivo Nanotoxicology Studies32Anticancer drug encapsulated in inorganic lattice can overcome drug resistance97Bionanocomposites based on alginate–zein/layered double hydroxide materials as drug delivery systems266The in vitro and in vivo anti-tumor effect of layered double hydroxides nanoparticles as delivery for podophyllotoxin83Intercalation of linear C9–C16 carboxylates in layered FeII–FeIII-hydroxides (green rust) via ion exchange40Immobilization of biomolecules on the surface of inorganic nanoparticles for biomedical applications55Biological evaluation of layered double hydroxides as efficient drug vehicles41Formation of Hydroxyapatite Nanocrystals on the Surface of Ca–Al‐Layered Double Hydroxide23Folic Acid-Conjugated Chitosan Nanoparticles Enhanced Protoporphyrin IX Accumulation in Colorectal Cancer Cells289Preparation of an anion dye intercalated into layered double hydroxides and its controllable luminescence properties61Synthesis and characterization of a strong-fluorescent Eu-containing hydrotalcite-like compound9Synthesis and release behavior of composites of camptothecin and layered double hydroxide90Layered Double Hydroxides Based Ceramic Nanocapsules as Reservoir and Carrier of Functional Anions12Characterization and Stability Analysis of Zinc Oxide Nanoencapsulated Conjugated Linoleic Acid19Hydrothermal Synthesis of Glutamic Acid/Layered Double Hydroxide Compounds6Unveiling the mechanism of uptake and sub-cellular distribution of cerium oxidenanoparticles177Bioinspired Layered Nanomaterials in Medical Therapy3Biomedical Applications of Layered Double Hydroxides5Effect of Process Variations on Anticancerous Drug Intercalation in Ceramic Based Delivery System9Inorganic-polymer nanohybrid carrier for delivery of a poorly-soluble drug, ursodeoxycholic acid41The use of layered double hydroxides as DNA vaccine delivery vector for enhancement of anti-melanoma immune response119Controlled release of ketorolac through nanocomposite films of hydrogel and LDH nanoparticles20Solubility and release of fenbufen intercalated in Mg, Al and Mg, Al, Fe layered double hydroxides (LDH): The effect of Eudragit® S 100 covering45Développement et caractérisation de nouveaux systèmes hybrides inorganique/organique pour la formulation de principes actifs0Dissolution of nano-size Mg–Al–Cl hydrotalcite in aqueous media127A Lattice‐Engineering Route to Heterostructured Functional Nanohybrids46Integrated bio-inorganic hybrid systems for nano-forensics57A sustained folic acid release system based on ternary magnesium/zinc/aluminum layered double hydroxides26Clay particles - potential of positron annihilation lifetime spectroscopy (PALS) for studying interlayer spacing6Effect of physico-chemical parameters on the toxicity of inorganic nanoparticles62Layered Double Hydroxides as Controlled Release Materials13The Synthesis and Characterization of Gold-Core/LDH-Shell Nanoparticles0Using Kaolinitic Clay for Preparation of a Hydrotalcite-Like Compound7Liposomal architecture boosts biocompatibility of nanohybrid cerasomes38Fluorescence of Mg-Al-Eu Ternary Layered Double Hydroxide Sensitivity to Phenylalanine19Preparation of acrylic acid and AMPS cointercalated layered double hydroxide and its application for superabsorbent25Simple and Mixed Metal Oxides and Hydroxides: Solids with Extended Structures of Different Dimensionalities and Porosities2Effect of Metal Ion Concentration on the Property of Methotraexate/Layered Double Hydroxide Compounds2層状複水酸化物のドラッグデリバリー材料としての応用( 層状複水酸化物の応用-陰イオン交換特性の利用-)0Layered double hydroxide: Inorganic organic conjugate nanocarrier for methotrexate31An optical sensor based on H-acid/layered double hydroxide composite film for the selective detection of mercury ion37Inorganic nanoparticles for cancer imaging and therapy618Cellular trafficking of low molecular weight heparin incorporated in layered double hydroxide nanoparticles in rat vascular smooth muscle cells67Layered Double Hydroxide Nanoparticles as Target-Specific Delivery Carriers: Uptake Mechanism and Toxicity194WITHDRAWN: Inorganic nanoparticles for cancer imaging and therapy3Preformulation studies on host–guest composites for oral administration of BCS class IV drugs: HTlc and furosemide30Methotrexate intercalated ZnAl-layered double hydroxide76Preparation, characterization, and release behavior of nanocomposite microparticles based on polystyrene and different layered silicates6A facile synthetic strategy for Mg–Al layered double hydroxide material as nanocarrier for methotrexate57Synthesis of Highly Luminescent and Anion‐Exchangeable Cerium‐Doped Layered Yttrium Hydroxides for Sensing and Photofunctional Applications77Confinement and controlled release of quinine on chitosan–montmorillonite bionanocomposites42Preparation of hippurate-zinc layered hydroxide nanohybrid and its synergistic effect with tamoxifen on HepG2 cell lines49Nano/Microporous Materials: Nanostructured Layered Double Hydroxides3Efficiency of layered double hydroxide nanoparticle-mediated delivery of siRNA is determined by nucleotide sequence59Intercalation of Anti-inflammatory Drugs Sodium Indomethacin into Nanocomposites of Mg-Al. Structural Characterization7Interlayer Structure of Bioactive Molecule, 2‐Aminoethanesulfonate, Intercalated into Calcium‐Containing Layered Double Hydroxides15Preparation and Characterization of Folate Conjugated Nanoparticles of Doxorubicin using Plga-Peg-Fol Polymer41Preparation and evaluation of well-defined hemocompatible layered double hydroxide-poly(sulfobetaine) nanohybrids56Synthesis of chitosan-coated near-infrared layered double hydroxide nanoparticles for in vivo optical imaging90Synthesis of layered double hydroxide nanoparticles in a novel microemulsion27Hierarchical Nanocomposites Derived from Nanocarbons and Layered Double Hydroxides ‐ Properties, Synthesis, and Applications590Luminescent drug-containing hydrotalcite-like compound as a drug carrier18One-Step Bulk Preparation of Calcium Carbonate Nanotubes and Its Application in Anticancer Drug Delivery5A nanohybrid system for taste masking of sildenafil36CELLULAR UPTAKE BEHAVIOR OF FLUORESCEIN: INTERCALATED LAYERED DOUBLE HYDROXIDE4Hidrotalcite with Gentamicine, of the Type Mg0.68Al0.32(OH)2(NO3)0.32*0.1H2O, Formed by Chemical Coprecipitation in Controlled Atmosphere0Preparation, mechanical properties and thermal stability of poly(l-lactide)/γ-polyglutamate-modified layered double hydroxide nanocomposites32Drug‐Ceramic 2‐Dimensional Nanoassemblies for Drug Delivery System in Physiological Condition33

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  1. LDH-DNA Nanohybrids: a complete biophysical characterization

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  2. Nanoscale Layered Double Hydroxide Materials with Organic Anions Intercalation

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  3. Novel layered pesticide slow/controlled release materials -- supramolecular structure and slow release property of glyphosate intercalated layered double hydroxides

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  4. Study on the supramolecular structure of sorbic acid inter-calated Zn-Al layered double hydroxides and its thermal decomposition

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  5. Synthesis and properties of Mg2Al layered double hydroxides containing 5-fluorouracil

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  6. Immobilization of Ibuprofen and Copper-Ibuprofen Drugs on Layered Double Hydroxides

    Journal of Pharmaceutical Sciences · 2005-03-25

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  7. Adsorption and intercalation of anionic surfactants onto layered double hydroxides—XRD study

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  8. Intercalation of Natural Cyclodextrins into Layered Double Hydroxide by Calcination–Rehydration Reaction

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  9. Nano/Microporous Materials: Nanostructured Layered Double Hydroxides

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  10. Applications of Layered Double Hydroxides

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  11. Selective anion-exchange intercalation of isomeric benzoate anions into the layered double hydroxide [LiAl2(OH)6]Cl·H2O

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  12. In Situ Polymerization and Intercalation of Polymers in Layered Double Hydroxides

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  13. Preparation and characterization of a new layered double hydroxide, Co–Zr–Si

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  14. Towards understanding, control and application of layered double hydroxide chemistry

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  15. Ultrasound-mediated release of [Ru(bpy) 3 ] 2+ from a layered titanate film—a model for controlled drug release from layered metal oxide films

    Journal of Materials Chemistry · 2006-01-01

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  16. Synthesis and adsorption properties of p-sulfonated calix[4 and 6]arene-intercalated layered double hydroxides

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  17. Efficient delivery of anticancer drug MTX through MTX-LDH nanohybrid system

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  18. Intracrystalline structure of DNA molecules stabilized in the layered double hydroxide

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  19. Intercalation of amino acids and oligopeptides into Zn–Al layered double hydroxide by coprecipitation reaction

    Journal of Physics and Chemistry of Solids · 2006-03-14

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  20. Intercalation of dipeptides during V2O5.nH2O xerogel condensation

    Journal of Physics and Chemistry of Solids · 2006-03-21

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  21. Biological Hybrid Materials for Drug Delivery System

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  22. Experimental Investigations of Amino Acid-Layered Double Hydroxide Complexes: Glutamate−Hydrotalcite

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  23. The dynamic process in the formation of Tyr/LDH nanohybrids

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  24. Applications of Layered Double Hydroxides

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  25. Biocompatible protoporphyrin IX-containing nanohybrids with potential applications in photodynamic therapy

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  26. Intercalation of hydrophilic and hydrophobic antibiotics in layered double hydroxides

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  27. Nanoceramics-Biomolecular Conjugates for Gene and Drug Delivery

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  28. Intercalation behavior of l-ascorbic acid into layered double hydroxides

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  29. Cellular Uptake Mechanism of an Inorganic Nanovehicle and Its Drug Conjugates: Enhanced Efficacy Due To Clathrin-Mediated Endocytosis

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  30. One-pot synthetic route to polymer–silica assembled capsule encased with nonionic drug molecule

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  31. Clay minerals and layered double hydroxides for novel biological applications

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  32. New Inorganic-Based Drug Delivery System of Indole-3-Acetic Acid-Layered Metal Hydroxide Nanohybrids with Controlled Release Rate

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  33. The construction and characterization of layered double hydroxides as delivery vehicles for podophyllotoxins

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  34. Laponite-based nanohybrid for enhanced solubility and controlled release of itraconazole

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  35. Preparation and characterization of a new nano layered material, Co–Zr LDH

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  36. Ceramic nanovector based on layered double hydroxide: attributes, physiologically relevant compositions and surface activation

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  37. Itraconazole–Laponite: Kinetics and mechanism of drug release

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  38. Human-related application and nanotoxicology of inorganic particles: complementary aspects

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  39. Preparation of a new nano-layered materials and organic–inorganic nano-hybrid materials, Zn–Si LDH

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  40. Anticancer drug-layered hydroxide nanohybrids as potent cancer chemotherapy agents

    Journal of Physics and Chemistry of Solids · 2007-12-04

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  41. Bio‐Inorganic Conjugates for Drug and Gene Delivery

    Unknown journal · 2007-12-12

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  42. Development of controlled drug release formulation based on pamoate-zinc-aluminium-layered double hydroxide nano composite

    Unknown journal · 2008-01-01

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  43. Preparation of titanate coated magnetite powder for cisplatin delivery

    Journal of the Ceramic Society of Japan · 2008-01-01

    Shinichi Kikkawa, Shigeaki TAKAGI, Hiroki Tamura

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  44. Synthesis of unusual coral-like layered double hydroxide microspheres in a nonaqueous polar solvent/surfactant system

    Journal of Materials Chemistry · 2008-01-01

    Poernomo Gunawan, Rong Qing Xu

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  45. Insertion of chromium(III) ascorbate complex into layered double hydroxide through reduction of intercalated chromate by ascorbic acid

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  46. 水溶性铑膦配合物插层水滑石的制备及主、客体组成对其催化性能的影响

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  47. Gene and Drug Delivery System with Soluble Inorganic Carriers

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  48. Direct Control of Drug Release Behavior from Layered Double Hydroxides through Particle Interactions

    Journal of Pharmaceutical Sciences · 2008-02-12

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  49. Preparation and intercalation reactions of nano-structural materials, Zn–Al–Ti LDH

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  50. LDH Nanocomposites with Different Guest Entities as Precursors of Supported Ni Catalysts

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