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RESEARCH PAPER · Journal of Pharmaceutical Sciences · 2005

Immobilization of Ibuprofen and Copper-Ibuprofen Drugs on Layered Double Hydroxides

Cláudia R. Gordijo, César Augusto Sales Barbosa, Ana Maria da Costa Ferreira, Vera Regina Leopoldo Constantino, Denise de Oliveira Silva

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Immobilization of Ibuprofen and Copper-Ibuprofen Drugs on Layered Double HydroxidesOriginalDetection of Drug−Membrane Interactions in Individual Phospholipid Vesicles by Confocal Raman Microscopy72Ordered Mesoporous Materials in the Context of Drug Delivery Systems and Bone Tissue Engineering515Submicron Particles of SBA-15 Modified with MgO as Carriers for Controlled Drug Delivery65Synthesis, crystal structure, spectroscopic and electrochemical characterization of the dinuclear complex {tetra-μ-[(±)-2-(p-methoxyphenoxy)-propionato-O,O′]bis(aqua)dicopper(II)}3Layered double hydroxides and human health: An overview✠400Evidences for decarbonation and exfoliation of layered double hydroxide in N,N-dimethylformamide–ethanol solvent mixture66The construction and characterization of layered double hydroxides as delivery vehicles for podophyllotoxins20Diclofenac-hydrotalcite: In vitro and in vivo release experiments25Synthesis of unusual coral-like layered double hydroxide microspheres in a nonaqueous polar solvent/surfactant system72Direct Control of Drug Release Behavior from Layered Double Hydroxides through Particle Interactions81In Vitro Sustained Release of LMWH from MgAl-layered Double Hydroxide Nanohybrids257Intercalation of l -Dopa into Layered Double Hydroxides: Enhancement of Both Chemical and Stereochemical Stabilities of a Drug through Host−Guest Interactions120Interactions of Ibuprofen with Hybrid Lipid Bilayers Probed by Complementary Surface-Enhanced Vibrational Spectroscopies75Cation exchange by anion-exchanging clays: the effects of particle aging31Cationic inorganic materials for anionic pollutant trapping and catalysis237Controlled synthesis of layered double hydroxide compounds with novel morphologies for biological applications0Layered nanomaterials for green materials215Poly( L ‐lactic acid) nanocomposites with layered double hydroxides functionalized with ibuprofen56Synthesis, Characterization, and Magnetically Controlled Release Behavior of Novel Core−Shell Structural Magnetic Ibuprofen-Intercalated LDH Nanohybrids101Layered double hydroxide nanoparticles in gene and drug delivery284Bioinorganic Magnetic Core−Shell Nanocomposites Carrying Antiarthritic Agents: Intercalation of Ibuprofen and Glucuronic Acid into Mg−Al−Layered Double Hydroxides Supported on Magnesium Ferrite106Bionanocomposites based on alginate–zein/layered double hydroxide materials as drug delivery systems266Hybrid materials based on clays for environmental and biomedical applications324Design of magnetic and fluorescent Mg–Al layered double hydroxides by introducing Fe3O4 nanoparticles and Eu3+ ions for intercalation of glycine16Layered Double Hydroxides Based Ceramic Nanocapsules as Reservoir and Carrier of Functional Anions12Dissolution kinetics and mechanism of Mg–Al layered double hydroxides: A simple approach to describe drug release in acid media116Biomedical Applications of Layered Double Hydroxides5Mesoporous mixed metal oxides derived from P123-templated Mg–Al layered double hydroxides25Influence of Metal Cations on the Structure and Release Property of Layered Double Hydroxide-Ibuprofen Host-Guest Materials7Magnetic, Luminescent Eu‐Doped Mg–Al Layered Double Hydroxide and Its Intercalation for Ibuprofen44A sustained folic acid release system based on ternary magnesium/zinc/aluminum layered double hydroxides26A rational approach to screen for hydrated forms of the pharmaceutical derivative magnesium naproxen using liquid-assisted grinding45Applications of advanced hybrid organic–inorganic nanomaterials: from laboratory to market1462Magnetic nanocomposites with drug-intercalated layered double hydroxide shell supported on commercial magnetite and laboratory-made magnesium ferrite core materials26Layered double hydroxide: Inorganic organic conjugate nanocarrier for methotrexate31Inorganic nanoparticles for cancer imaging and therapy618WITHDRAWN: Inorganic nanoparticles for cancer imaging and therapy3Preparação e caracterização de materiais híbridos bioinorgânico-orgânicos contendo metalofármacos de cobre-naproxeno e de cobre-sulindaco em acetato de celulose0Intercalation of paracetamol into the hydrotalcite-like host30Binuclear copper complexes with non-steroidal anti-inflammatory drugs as studied by electrospray ionization mass spectrometry8Polymer nanocomposites for improved drug delivery efficiency56CELLULAR UPTAKE BEHAVIOR OF FLUORESCEIN: INTERCALATED LAYERED DOUBLE HYDROXIDE4Structural, Spectroscopic (NMR, IR, and Raman), and DFT Investigation of the Self-Assembled Nanostructure of Pravastatin-LDH (Layered Double Hydroxides) Systems81The application of layered double hydroxide clay (LDH)-poly(lactide-co-glycolic acid) (PLGA) film composites for the controlled release of antibiotics50Modeling drug release from a layered double hydroxide–ibuprofen complex93Synthesis and characterization of laurate-intercalated Mg–Al layered double hydroxide prepared by coprecipitation27Avaliação da citotoxicidade e das atividades analgésica e anti-inflamatória do ácido p-coumárico intercalado em nanopartículas de hidróxidos duplos lamelares0Facile fabrication of ibuprofen–LDH nanohybrids via a delamination/reassembling process35Effects of microcrystalline cellulose based comilled powder on the compression and dissolution of ibuprofen19Drug Delivery Using Nanosized Layered Double Hydroxide, an Anionic Clay10Synthesis, characterization and release of a-naphthaleneacetate from thin films containing Mg/Al-layered double hydroxide9Bioinspired Nacre-like Heparin/Layered Double Hydroxide Film with Superior Mechanical, Fire-Shielding, and UV-Blocking Properties38Layered Double Hydroxide-Based Nanocarriers for Drug Delivery249Bionanocomposites containing magnetic graphite as potential systems for drug delivery46Nanohybrid Based on Antibiotic Encapsulated Layered Double Hydroxide as a Drug Delivery System20Synthesis and Characterization of Layered Double Hydroxides and Their Potential as Nonviral Gene Delivery Vehicles71Interaction of chitosan beads with a copper–naproxen metallodrug9Preparation and characterization of biologically active novel copper ion-pairs of nonsteroidal anti-inflammatory drugs (NSAIDs)2Espectroscopia Raman aplicada ao estudo da resposta bioquímica de tecidos a compostos lamelares0Delivery system for mefenamic acid based on the nanocarrier layered double hydroxide: Physicochemical characterization and evaluation of anti-inflammatory and antinociceptive potential55Evaluation of IN SITU synthesis route of layered hydroxides in the presence of amphiphilic polymers in comparison with their corresponding physical mixtures0One-pot synthesis of perovskite-type metal oxides via confined mesopore and their catalytic activity for toluene oxidation11Continuous flow synthesis and cleaning of nano layered double hydroxides and the potential of the route to adjust round or platelet nanoparticle morphology18CaAl-layered double hydroxide as a drug delivery system: effects on solubility and toxicity of the antiretroviral efavirenz29MgAl- Layered Double Hydroxide Nanoparticles for controlled release of Salicylate48Modified drug release system based on Sulindac and layered double hydroxide: An in vivo Raman investigation20Impacto de aspectos nanoestruturais sobre a estabilidade de corantes e pigmentos de interesse arqueológico0Electrospun organic–inorganic nanohybrids as sustained release drug delivery systems40Structure and analgesic properties of layered double hydroxides intercalated with low amounts of ibuprofen9Synthesis, characterization, and sustained release property of Fe 3 O 4 @(enrofloxacin-layered double hydroxides) nanocomposite29Betamethasone dipropionate intercalated layered double hydroxide and the composite with liposome for improved water dispersity25Functional layered double hydroxides and their catalytic activity for 1,4-addition of n -octanol to 2-propenonitrile10Controlled release of ibuprofen using Mg Al LDH nano carrier21Synthesis and In Vitro Characterization of Fe3+-Doped Layered Double Hydroxide Nanorings as a Potential Imageable Drug Delivery System15Fabrication, controlled release, and kinetic studies of indomethacin—layered zinc hydroxide nanohybrid and its effect on the viability of HFFF219Improving the Carprofen Solubility: Synthesis of the Zn2Al-LDH Hybrid Compound33Nanoparticules d’hydroxydes doubles lamellaires élaborées à partir de micelles complexes de copolymères hydrosolubles : Synthèse directe en milieu aqueux et étude de la croissance et de la stabilisation0Fine-tuning the release of molecular guests from mesoporous silicas by controlling the orientation and mobility of surface phenyl substituents19Tailored Nanoparticles by Wet Chemical Particle Technology8Surface PEGylation and biological imaging of fluorescent Tb3+-doped layered double hydroxides through the photoinduced RAFT polymerization14A Copper10-Paclitaxel crystal; a medicinally active drug delivery platform6Ibuprofen Intercalation and Release From Different Layered Double Hydroxides21Customizable heterogeneous catalysts: From 3D printed designs to mesoporous materials2A Ru(II)-p-cymene compound bearing naproxen-pyridineamide. Synthesis, spectroscopic studies, computational analysis and in vitro anticancer activity against lung cells compared to Ru(II)-p-cymene-naproxen and the corresponding drug ligands18Copper(II) complexes as potential anticancer and Nonsteroidal anti-inflammatory agents: In vitro and in vivo studies275Meloxicam-LDH Hybrid Compound: A Successful Strategy to Improve Solubility14Nanoencapsulamento de metalofármacos antitumorais de dirutênio(II,III) contendo ibuprofeno e naproxeno. Estudo de um novo metalofármaco misto de µ-oxo-rutênio(III)-ibuprofeno-4-aminopiridina0Improve the Role of Ibuprofen in the Biological Field: Short Review2Curcumin Incorporation into Zn3Al Layered Double Hydroxides—Preparation, Characterization and Curcumin Release16pH- and temperature-responsive radially porous silica nanoparticles with high-capacity drug loading for controlled drug delivery45New nanocarried phenobarbital formulation: Maintains better control of pentylenetetrazole-Induced seizures5Ibuprofen Release from Hydrotalcite-like Materials Filled into Chitosan/Alginate Composites as Promising Reabsorbable Membranes6Solid-Phase Adsorption of Curcumin from Turmeric Extracts by Lamellar Solids and Magnesium Oxide and Hydroxide9Synthesis of Layered Double Hydroxides Intercalated With Drugs for Controlled Release: Successful Intercalation of Ibuprofen and Failed Intercalation of Paracetamol21In situ assembling of layered double hydroxide to magadiite layered silicate with enhanced photocatalytic and recycling performance21Ciprofloxacin in Layered Double Hydroxides: Looking for the Best Synthesis Method3Anti-Inflammatory and Analgesic Evaluation of a Phytochemical Intercalated into Layered Double Hydroxide13A review on the current progress of layered double hydroxide application in biomedical sectors21Zaltoprofen-layered double hydroxide hybrids to enhance zaltoprofen solubility and dissolution rate7Drug-Intercalated Zn–Al-Layered Double Hydroxides as Antibacterial and Anti-inflammatory Delivery Systems for Wound Healing Applications14Development of Dipeptide N–acetyl–L–cysteine Loaded Nanostructured Carriers Based on Inorganic Layered Hydroxides4Estudo de processo inflamatório articular por espectroscopia Raman: ação de compostos lamelares e detecção de alterações fisiológicas0Experimental Design Modelling and Optimization of the Intercalation of Levofloxacin and Salicylic Acid into the Structure of ZnAl-LDH by Response Surface Method: in vitro Study of Release Kinetics, Antibacterial and Anti- Inflammatory Activities1Carboxymethylcellulose/layered double hydroxide dispersions for topical ocular delivery of non-steroidal anti-inflammatory drugs5Comparative Adsorption Performance of Ibuprofen from Aqueous Solution on the Activated Carbon, Mgal/Ldh, and Mgal/Ldh-Activated Carbon Composite0Interaction of Tapentadol with Selected Metal Ions Studied by UV-Vis and FTIR Spectroscopy0

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  1. Detection of Drug−Membrane Interactions in Individual Phospholipid Vesicles by Confocal Raman Microscopy

    Analytical Chemistry · 2006-05-28

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  2. Ordered Mesoporous Materials in the Context of Drug Delivery Systems and Bone Tissue Engineering

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  3. Submicron Particles of SBA-15 Modified with MgO as Carriers for Controlled Drug Delivery

    Chemical and Pharmaceutical Bulletin · 2007-01-01

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  4. Synthesis, crystal structure, spectroscopic and electrochemical characterization of the dinuclear complex {tetra-μ-[(±)-2-(p-methoxyphenoxy)-propionato-O,O′]bis(aqua)dicopper(II)}

    Transition Metal Chemistry · 2007-02-24

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  5. Layered double hydroxides and human health: An overview✠

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  6. Evidences for decarbonation and exfoliation of layered double hydroxide in N,N-dimethylformamide–ethanol solvent mixture

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  7. The construction and characterization of layered double hydroxides as delivery vehicles for podophyllotoxins

    Journal of Materials Science Materials in Medicine · 2007-08-14

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  8. Diclofenac-hydrotalcite: In vitro and in vivo release experiments

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  9. Synthesis of unusual coral-like layered double hydroxide microspheres in a nonaqueous polar solvent/surfactant system

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  10. Direct Control of Drug Release Behavior from Layered Double Hydroxides through Particle Interactions

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  11. In Vitro Sustained Release of LMWH from MgAl-layered Double Hydroxide Nanohybrids

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  12. Intercalation of l -Dopa into Layered Double Hydroxides: Enhancement of Both Chemical and Stereochemical Stabilities of a Drug through Host−Guest Interactions

    Chemistry of Materials · 2008-07-30

    Min Wei, Min Pu, Jian Ting Guo, Jingbin Han, Feng Li, Jing He, David G. Evans, Xue Duan

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  13. Interactions of Ibuprofen with Hybrid Lipid Bilayers Probed by Complementary Surface-Enhanced Vibrational Spectroscopies

    The Journal of Physical Chemistry B · 2008-10-23

    Carly S. Levin, Janardan Kundu, Benjamin G. Janesko, Gustavo E. Scuseria, Robert M. Raphael, Naomi J. Halas

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  14. Cation exchange by anion-exchanging clays: the effects of particle aging

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  15. Cationic inorganic materials for anionic pollutant trapping and catalysis

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  16. Controlled synthesis of layered double hydroxide compounds with novel morphologies for biological applications

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  17. Layered nanomaterials for green materials

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  18. Poly( L ‐lactic acid) nanocomposites with layered double hydroxides functionalized with ibuprofen

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  19. Synthesis, Characterization, and Magnetically Controlled Release Behavior of Novel Core−Shell Structural Magnetic Ibuprofen-Intercalated LDH Nanohybrids

    The Journal of Physical Chemistry C · 2009-06-22

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  20. Layered double hydroxide nanoparticles in gene and drug delivery

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  21. Bioinorganic Magnetic Core−Shell Nanocomposites Carrying Antiarthritic Agents: Intercalation of Ibuprofen and Glucuronic Acid into Mg−Al−Layered Double Hydroxides Supported on Magnesium Ferrite

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  22. Bionanocomposites based on alginate–zein/layered double hydroxide materials as drug delivery systems

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  23. Hybrid materials based on clays for environmental and biomedical applications

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  24. Design of magnetic and fluorescent Mg–Al layered double hydroxides by introducing Fe3O4 nanoparticles and Eu3+ ions for intercalation of glycine

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  25. Layered Double Hydroxides Based Ceramic Nanocapsules as Reservoir and Carrier of Functional Anions

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  26. Dissolution kinetics and mechanism of Mg–Al layered double hydroxides: A simple approach to describe drug release in acid media

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  27. Biomedical Applications of Layered Double Hydroxides

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  28. Mesoporous mixed metal oxides derived from P123-templated Mg–Al layered double hydroxides

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  29. Influence of Metal Cations on the Structure and Release Property of Layered Double Hydroxide-Ibuprofen Host-Guest Materials

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  30. Magnetic, Luminescent Eu‐Doped Mg–Al Layered Double Hydroxide and Its Intercalation for Ibuprofen

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  32. A rational approach to screen for hydrated forms of the pharmaceutical derivative magnesium naproxen using liquid-assisted grinding

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  37. WITHDRAWN: Inorganic nanoparticles for cancer imaging and therapy

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  38. Preparação e caracterização de materiais híbridos bioinorgânico-orgânicos contendo metalofármacos de cobre-naproxeno e de cobre-sulindaco em acetato de celulose

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  39. Intercalation of paracetamol into the hydrotalcite-like host

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  40. Binuclear copper complexes with non-steroidal anti-inflammatory drugs as studied by electrospray ionization mass spectrometry

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  41. Polymer nanocomposites for improved drug delivery efficiency

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  42. CELLULAR UPTAKE BEHAVIOR OF FLUORESCEIN: INTERCALATED LAYERED DOUBLE HYDROXIDE

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  43. Structural, Spectroscopic (NMR, IR, and Raman), and DFT Investigation of the Self-Assembled Nanostructure of Pravastatin-LDH (Layered Double Hydroxides) Systems

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  44. The application of layered double hydroxide clay (LDH)-poly(lactide-co-glycolic acid) (PLGA) film composites for the controlled release of antibiotics

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  45. Modeling drug release from a layered double hydroxide–ibuprofen complex

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  46. Synthesis and characterization of laurate-intercalated Mg–Al layered double hydroxide prepared by coprecipitation

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  47. Avaliação da citotoxicidade e das atividades analgésica e anti-inflamatória do ácido p-coumárico intercalado em nanopartículas de hidróxidos duplos lamelares

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  48. Facile fabrication of ibuprofen–LDH nanohybrids via a delamination/reassembling process

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  49. Effects of microcrystalline cellulose based comilled powder on the compression and dissolution of ibuprofen

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  50. Drug Delivery Using Nanosized Layered Double Hydroxide, an Anionic Clay

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