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RESEARCH PAPER · International Journal of Pharmaceutics · 2014

Pectin-coated chitosan–LDH bionanocomposite beads as potential systems for colon-targeted drug delivery

Lígia Nunes de Morais Ribeiro, Ana C. S. Alcântara, Margarita Darder, Pîlar Aranda, Fernando Manuel Araújo-Moreira, Eduardo Ruiz‐Hitzky

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Pectin-coated chitosan–LDH bionanocomposite beads as potential systems for colon-targeted drug deliveryOriginalPoly-vinyl alcohol (PVA) and malachite green: a new reagent system for the microdetermination of phosphate in water and wastewater.7Potential for Layered Double Hydroxides-Based, Innovative Drug Delivery Systems119Layered Double Hydroxide-Based Nanocarriers for Drug Delivery249Investigation of electrical stimulus on chitosan film based DDS0Novel pectin-based carriers for colonic drug delivery45Bionanocomposites containing magnetic graphite as potential systems for drug delivery46Pectin-Chitosan Multilayer Coated Microbeads of Diclofenac Sodium Prepared by Layer-by-Layer Technique1Hierarchical layered double hydroxide nanocomposites: structure, synthesis and applications389Robust and versatile pectin-based drug delivery systems41Design of chitospheres loaded with pristine polymer particles for extended drug delivery via polyelectrolyte complexation and particulate leaching12Hierarchical coated metal hydroxide nanoconstructs as potential controlled release carriers of photosensitizer for skin melanoma34Preparation and Evaluation of Newly Developed Chitosan Salt Coating Dispersions for Colon Delivery without Requiring Overcoating6Preparation and application of micro/nanoparticles based on natural polysaccharides276Bone formation of a porous Gelatin-Pectin-biphasic calcium phosphate composite in presence of BMP-2 and VEGF79Exfoliation and dispersion of LDH modified with N-tetrabromophthaloyl-glutamic in poly(vinyl alcohol): Morphological and thermal studies8Nanohybrid organic–inorganic chitosan/dopamine/TiO2 composites with controlled drug-delivery properties54Development and in vitro/in vivo evaluation of Zn-pectinate microparticles reinforced with chitosan for the colonic delivery of progesterone46Complexos dos polieletrólitos quitosana e pectina para obtenção de sistemas carreadores de compostos bioativos0Layered double hydroxide nanoparticles for biomedical applications: Current status and recent prospects258Multi-laminated metal hydroxide nanocontainers for oral-specific delivery for bioavailability improvement and treatment of inflammatory paw edema in mice43Polysaccharide-layered double hydroxide–aldolase biohybrid beads for biocatalysed CC bond formation11Natural Polysaccharides as Pharmaceutical Excipients27Introduction3Reducing the content of carrier polymer in pectin nanofibers by electrospinning at low loading followed with selective washing62A layered drug nanovehicle toward targeted cancer imaging and therapy42Anionic clay as the drug delivery vehicle: tumor targeting function of layered double hydroxide-methotrexate nanohybrid in C33A orthotopic cervical cancer model53Chitosan seed soaking: germination and growth of Coriandrum sativum and Solanum lycopersicum4Calcium pectinate gel beads obtained from callus cultures pectins as promising systems for colon-targeted drug delivery87Amide pectin: A carrier material for colon‐targeted controlled drug release26MgAl- Layered Double Hydroxide Nanoparticles for controlled release of Salicylate48New aspects of controlled release systems for local anaesthetics: A review17Preparation and characterization of ibuprofen/modified chitosan/TiO 2 hybrid composite as a controlled drug-delivery system74Polysaccharide based bionanocomposites, properties and applications: A review210Nanostructured lipid carriers as robust systems for topical lidocaine-prilocaine release in dentistry110Preparation, characterization and application in controlled release of Ibuprofen-loaded Guar Gum/Montmorillonite Bionanocomposites80Enabling Nanohybrid Drug Discovery through the Soft Chemistry Telescope27Controlling chitosan degradation properties in vitro and in vivo58Microwave grafted, Composite and Coprocessed Materials: Drug Delivery Applications9Advances in Hybrid Polymer-Based Materials for Sustained Drug Release60Chitosan-based nanoparticulate systems for oral drug delivery6Pectin-zinc-chitosan-polyethylene glycol colloidal nano-suspension as a food grade carrier for colon targeted delivery of resveratrol93Bionanocomposite systems based on montmorillonite and biopolymers for the controlled release of olanzapine41Hybrid nanocomposites of layered double hydroxides: an update of their biological applications and future prospects62Pectins functionalized biomaterials; a new viable approach for biomedical applications: A review330Medicinal Plants in the Treatment of Colitis: Evidence from Preclinical Studies23A Colon Targeted Delivery System for Resveratrol Enriching in pH Responsive-Model24Pectin–chitosan physical hydrogels as potential drug delivery vehicles177Controlled release of metformin from chitosan–based nanocomposite films containing mesoporous MCM-41 nanoparticles as novel drug delivery systems150Chitosan-Based Delivery of Gene Therapeutics for Cancer0Pectin ‐Based Composites3Pharmaceutical Delivery Systems Composed of Chitosan1Bionanocomposite Materials for Biocatalytic Applications2pH-sensitive mesalazine carrier for colon-targeted drug delivery: A two-fold composition of mesalazine with a clay and alginate24Clay–Organic Interfaces for Design of Functional Hybrid Materials18Application Potential of Polymeric Nanoconstructs for Colon-Specific Drug Delivery12Layered gadolinium hydroxides for simultaneous drug delivery and imaging44Building Up Functional Bionanocomposites from the Assembly of Clays and Biopolymers37Emerging nanomaterials with advanced drug delivery functions; focused on methotrexate delivery92Synthesis of carboxymethyl cellulose-g-poly(acrylic acid)/LDH hydrogel for in vitro controlled release of vitamin B 12632D Nanostructured Metal Hydroxides with Gene Delivery and Theranostic Functions; A Comprehensive Review58Filmes mucoadesivos à base de quitosana e pectina contendo anestésicos locais0Layered Double Hydroxide/Chitosan Nanocomposite Beads as Sorbents for Selenium Oxoanions58Stabilization of antioxidant gallate in layered double hydroxide by exfoliation and reassembling reaction23Cerasomes and Bicelles: Hybrid Bilayered Nanostructures With Silica-Like Surface in Cancer Theranostics43Encapsulation for delivering bioactives in aquaculture65Controlled release of organic–inorganic nanohybrid:cefadroxil intercalated Zn–Al-layered double hydroxide41Bioresponsive drug delivery systems in intestinal inflammation: State-of-the-art and future perspectives242Preparation and release characteristics of mesalazine loaded calcium pectin-silica gel beads based on callus cultures pectins for colon-targeted drug delivery52Stability of Calcium–Alumino Layered-Double-Hydroxide Nanocomposites in Aqueous Electrolytes8Nanohybrid hydrogels designed for transbuccal anesthesia35Green and Sustainable Advanced Materials: An Overview11Functional Carboxymethylcellulose/Zein Bionanocomposite Films Based on Neomycin Supported on Sepiolite or Montmorillonite Clays53Encapsulated drug system based on the gels obtained from callus cultures modified pectins19New Drug Delivery Systems Concept in Anaesthesia and Intensive Care—Controlled Release of Active Compounds1Combined synergetic potential of metformin loaded pectin-chitosan biohybrids nanoparticle for NIDDM52Efficient and fast removal of Pb2+ and Cd2+ from an aqueous solution using a chitosan/Mg-Al-layered double hydroxide nanocomposite162Bimodal applications of LDH-chitosan nanocomposite: water treatment and antimicrobial activity5Chitin and Chitosan in Drug Delivery13Colonic Drug Delivery Systems as Multiunit Potential: Therapeutic Strategies and Opportunities0Enzyme Immobilization on Chitin and Chitosan-Based Supports for Biotechnological Applications43Nanostructured organic-organic bio-hybrid delivery systems14Organic nanocomposites for the delivery of bioactive molecules6Possibilities and perspectives of chitosan scaffolds and composites for tissue engineering10Recent advances in layered double hydroxide electrocatalysts for the oxygen evolution reaction604A review on 5-aminosalicylic acid colon-targeted oral drug delivery systems138Structuring of multiple parallel pectin gel filaments by applied shear3Clay-Based Biohybrid Materials for Biomedical and Pharmaceutical Applications32Complex of chitosan pectin and clay as diclofenac carrier43Bionanocomposites based on cationic and anionic layered clays as controlled release devices of amoxicillin56Design and Evaluation of Non-steroidal Anti-inflammatory Drug Intercalated into Layered Zinc Hydroxide as a Drug Delivery System9New Drug Delivery Systems Concept in Anaesthesia and Intensive Care—Controlled Release of Active Compounds0Enzyme-responsive mechanism based on multi-walled carbon nanotubes and pectin complex tablets for oral colon-specific drug delivery system19Preparation of Bifidobacterium breve encapsulated in low methoxyl pectin beads and its effects on yogurt quality54Carboxymethylcellulose-coated magnesium-layered hydroxide nanocomposite for controlled release of 3-(4-methoxyphenyl)propionic acid6Development of thermo/pH-responsive chitosan coated pectin-graft-poly(N,N-diethyl acrylamide) microcarriers51Layered double hydroxide based bionanocomposites129Biomedical and Nutraceutical Applications of Chitin and Chitosan4Synthesis and characterization of Zn/Al-LDH@SiO2 nanohybrid: Intercalation and release behavior of vitamin C47Design of solid foams for flame retardant based on bionanocomposites systems11Screening of different polysaccharides in a composite film based on Eudragit RS for subsequent use as a coating for delivery of 5-ASA to colon32Proceeding toward the development of poly(ɛ-caprolactone)/cellulose microfibrils electrospun biocomposites using a novel ternary solvent system16Iron-rich chitosan-pectin colloidal microparticles laden with ora-pro-nobis (Pereskia aculeata Miller) extract30Systematic Study of NaF Nanoparticles in Micelles loaded on Polylactic Acid Nanoscaffolds: In Vitro Efficient Delivery11Adsorption capacity evaluation of zeolites as carrier of isoniazid33Recent Progress in MRI Contrast Agent with Ceramic LDH Nanohybrids0Controlled release formulation of zinc hydroxide nitrate intercalated with sodium dodecylsulphate and bispyribac anions: A novel herbicide nanocomposite for paddy cultivation15Mucoadhesive films based on gellan gum/pectin blends as potential platform for buccal drug delivery64Carboxymethylcellulose/layered double hydroxides bio-nanocomposite hydrogel: A controlled amoxicillin nanocarrier for colonic bacterial infections treatment124Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action818Applications of layered double hydroxide biopolymer nanocomposites9Fabrication technologies of layered double hydroxide polymer nanocomposites10Layered double hydroxide based nanocomposites for biomedical applications7EXTRACTION AND CHARACTERISATION OF PECTIN FROM BANANA PEEL4Biomedical applications of bionanocomposites10Bionanocomposites from Biofibers and Biopolymers16Chitosan and pectin core–shell beads encapsulating metformin–clay intercalation compounds for controlled delivery48Preparation and Properties of Hydrogel Matrices based on Pectins from Callus Cultures1The impact of a hygroscopic chitosan coating on the controlled release behaviour of zinc hydroxide nitrate–sodium dodecylsulphate–imidacloprid nanocomposites12Recent Advances on the Use of Nickel Nano Layered Double Hydroxides as Green, and Efficient, Catalysts for Water Splitting32One-step in situ synthesis of nano silver-hydrotalcite coating for enhanced antibacterial and degradation property of magnesium alloys22Drug delivery applications of chitin and chitosan: a review307Biocompatible Hydrotalcite Nanohybrids for Medical Functions45Electrospun poly(lactic acid) nanofibers loaded with silver sulfadiazine/[Mg–Al]‐layered double hydroxide as an antimicrobial wound dressing52Clay-based hybrids for controlled release of 7-azaindole derivatives as neuroprotective drugs in the treatment of Alzheimer's disease31Design and preparation of quaternized pectin-Montmorillonite hybrid film for sustained drug release59On the taught new tricks of enzymes immobilization: An all-inclusive overview246Pectins as a universal medicine114Technological Development of Mucoadhesive Film Containing Poloxamer 407, Polyvinyl Alcohol and Polyvinylpyrrolidone for Buccal Metronidazole Delivery15Hybrid nanofilms as topical anesthetics for pain-free procedures in dentistry39Synthesis and characterization of a novel controlled release nitrogen-phosphorus fertilizer hybrid nanocomposite based on banana peel cellulose and layered double hydroxides nanosheets63Enhanced Oral Vaccine Efficacy of Polysaccharide-Coated Calcium Phosphate Nanoparticles64Dextran sulfate–modified pH-sensitive layered double hydroxide nanocomposites for treatment of rheumatoid arthritis34Hybrid Pectin-Liposome Formulation against Multi-Resistant Bacterial Strains32Chitosan as a coating material in enhancing the controlled release behaviour of zinc hydroxide nitrate–sodium dodecylsulphate–bispyribac nanocomposite8The peculiar dissolution behaviour of Piretanide hosted in layered double hydroxides9Mucoadhesive Formulation Designs for Oral Controlled Drug Release at the Colon12Natural proteins and polysaccharides in the development of micro/nano delivery systems for the treatment of inflammatory bowel disease81Pristine and modified chitosan as solid catalysts for catalysis and biodiesel production: A minireview44Recent progress in layered double hydroxides as a cancer theranostic nanoplatform39NiFeRu Layered Double Hydroxide and Its Derivatives Supported on Graphite Foam as Binder-Free Cathode for Nonaqueous Li-O2 Batteries3Reviewing the recent advances in application of pectin for technical and health promotion purposes: From laboratory to market163Inflammatory Bowel Disease: The Emergence of New Trends in Lifestyle and Nanomedicine as the Modern Tool for Pharmacotherapy32Functionalized biopolymers for colon-targeted drug delivery3Layered terbium hydroxides for simultaneous drug delivery and imaging18Polymer/layered double hydroxide nanocomposites: Modern industrial applications0Pectin-Based Formulations for Controlled Release of an Ellagic Acid Salt with High Solubility Profile in Physiological Media12Recent Advances in Colon Drug Delivery Technology1Comparative investigation of RSM and ANN for multi-response modeling and optimization studies of derived chitosan from Archachatina marginata shell39Reconstitution as an alternative method for 5-aminosalicylic acid intercalation in layered double hydroxide for drug delivery10Exploitation of Marine-Derived Robust Biological Molecules to Manage Inflammatory Bowel Disease16

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  1. Poly-vinyl alcohol (PVA) and malachite green: a new reagent system for the microdetermination of phosphate in water and wastewater.

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  4. Investigation of electrical stimulus on chitosan film based DDS

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  6. Bionanocomposites containing magnetic graphite as potential systems for drug delivery

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  7. Pectin-Chitosan Multilayer Coated Microbeads of Diclofenac Sodium Prepared by Layer-by-Layer Technique

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  21. Polysaccharide-layered double hydroxide–aldolase biohybrid beads for biocatalysed CC bond formation

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  23. Introduction

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  48. Controlled release of metformin from chitosan–based nanocomposite films containing mesoporous MCM-41 nanoparticles as novel drug delivery systems

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  49. Chitosan-Based Delivery of Gene Therapeutics for Cancer

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