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RESEARCH PAPER · Polysaccharides · 2025

Rationalizing Polysaccharide Extraction with Deep Eutectic Solvents: From Supramolecular Architecture to Emerging AI-Guided Solvent Design

Faisal Al‐Akayleh, Ahmed S.A. Ali Agha, Ali R. Olaimat, Nidal Adel Qinna

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Rationalizing Polysaccharide Extraction with Deep Eutectic Solvents: From Supramolecular Architecture to Emerging AI-Guided Solvent DesignOriginalMarine Macroalgal Polysaccharides as Precision Tools for Health and Nutrition8Insights and Innovations of Artificial Intelligence in Healthcare and Public Health: A Bibliometric Analysis4Influence of Deep Eutectic Solvents and Polyphenolic Extracts on the Structure and Functional Properties of Sodium Alginate Films9Optimization of Bioactive Polysaccharide Extraction from Protaetia brevitarsis seulensis Larvae Using Deep Eutectic Solvents1Advancement of deep eutectic solvents as catalyst/solvent for organic transformations and novel material for heavy metal depollution1Recent advances in polysaccharide extraction: Mechanisms, hybrid strategies, and emerging technologies5Navigating the Solubility Landscape of APIs in Deep Eutectic Solvents: A Data-Driven Thermodynamic Taxonomy of Solvation Regimes and Mechanisms0Next-generation green transdermal platforms: Integrating deep eutectic solvent chemistry with nanotechnology2Ultrahigh selectivity removal of trace amounts of thorium from acidic rare earth wastewater using a hydrophobic deep eutectic solvent1Support vector Regression-Optimized Ultrasonic-Assisted alkaline extraction of Chroogomphus rutilus Polysaccharides: Enhanced yield and preservation of helical conformations3Unlocking the Therapeutic Potential of Ganoderma lucidum : From Bioactive Compounds to Clinical Translation1Starch-Based Functional Ingredients in Baking: A Review of Advances in Starch Derivatives, Quality Enhancement, and Reduction of Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols0Emerging trends in plant biopolymer engineering: Green extraction, functional modification, and bioengineering applications4Deep eutectic solvent density prediction: Machine learning from quantum chemical descriptors reveals electronic and stoichiometric controls0A review of extraction methods, downstream processing, and green recovery innovations of microbial extracellular polysaccharides1Structural characterization and bioactivity evaluation of polysaccharides from Chrysanthemum indicum, Lycium barbarum, Rosa roxburghii, and Platycodon grandiflorum extracted by ultrasound-assisted deep eutectic solvents2Ultrasonic-assisted ternary deep eutectic solvent extraction of polysaccharides from fermented black beans (Dan-Dou-Chi): structural features, antioxidant, and hypoglycemic activities0Role of deep eutectic solvents for the extraction of polysaccharides from seaweed for food applications2Structural programmability of jujube polysaccharides: Extraction, molecular architecture, and microbiota-mediated fermentation Design for gut–Brain-Axis-Relevant Applications0Deep Eutectic Solvents for Circular Waste Valorization: A Review and Future Perspectives Bridging Plastics, Biomass, and e-Waste0A comprehensive study on the relationship between structure and antioxidant activity of natural deep eutectic solvent extracted polysaccharides from Chinese yam peel using asymmetrical flow field-flow fractionation0Eco-Friendly Deep Eutectic Solvent-Based Extraction Technologies: A Comprehensive Review of Principles, Applications, and Comparative Insights1Red Seaweed-Derived Phycobiliproteins: Marine Bioactive Colorants with Functional Health Properties0Atmospheric Cold Plasma-Induced Interaction of Soy Protein Isolate/Dextran for Electrospraying and In Vitro Sustained Release of Acemannan Extracted from Aloe Vera Gel0Beyond Polysaccharides: Multifunctional Roles of Plant‐Derived Conjugates in Sensory Enhancement and Food Quality Improvement0Ultrasound-Assisted enzymatic extraction of polysaccharides from agricultural By-Products: A comprehensive review1Beyond Composition: Structure–Activity Relationships in Bioactive Deep Eutectic Systems0Ultrasound-assisted sustainable extraction of Poncirus trifoliata flavonoid glycosides using a ternary NADES: RSM-ANN-PSO optimization, molecular mechanism and environmental sustainability0The engineering lifecycle of fungal chitin-glucan complexes: Extraction, multiscale modification, and translational quality assessment0Deep eutectic solvents for the precision extraction of natural polysaccharides: Mechanism, structural integrity, and machine learning perspectives0Artificial intelligence-driven paradigm shifts in functional food ingredient research0Yeast Cell Wall polysaccharides in wine aroma stabilisation: Mechanisms, regulation, and applications0Ultrasound-Assisted Simultaneous and Efficient Extraction of Flavonoids and Polysaccharides from Hawthorn ( Crataegus pinnatifida ): Optimization and Bioactivity0Extraction-dependent structure–activity relationships of Panax quinquefolius L. polysaccharides: A comparative study0Extraction, Structure–Activity Relationships, and Modification of Plant-Derived Polysaccharides: An Integrated Framework for Evidence-Based Method Selection and Bioactivity Optimization—A Review0A Review of Circular Pharmaceutics: Plant Mucilage as Tunable Bio-Based Polymers for Advanced Drug Delivery0Polysaccharide/polyacrylamide fluorescent eutectogels with enhanced clustering-triggered emission for food spoilage detection and information encryption0

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  3. Influence of Deep Eutectic Solvents and Polyphenolic Extracts on the Structure and Functional Properties of Sodium Alginate Films

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  10. Support vector Regression-Optimized Ultrasonic-Assisted alkaline extraction of Chroogomphus rutilus Polysaccharides: Enhanced yield and preservation of helical conformations

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  14. Deep eutectic solvent density prediction: Machine learning from quantum chemical descriptors reveals electronic and stoichiometric controls

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  15. A review of extraction methods, downstream processing, and green recovery innovations of microbial extracellular polysaccharides

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  16. Structural characterization and bioactivity evaluation of polysaccharides from Chrysanthemum indicum, Lycium barbarum, Rosa roxburghii, and Platycodon grandiflorum extracted by ultrasound-assisted deep eutectic solvents

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  17. Ultrasonic-assisted ternary deep eutectic solvent extraction of polysaccharides from fermented black beans (Dan-Dou-Chi): structural features, antioxidant, and hypoglycemic activities

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  18. Role of deep eutectic solvents for the extraction of polysaccharides from seaweed for food applications

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  19. Structural programmability of jujube polysaccharides: Extraction, molecular architecture, and microbiota-mediated fermentation Design for gut–Brain-Axis-Relevant Applications

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  21. A comprehensive study on the relationship between structure and antioxidant activity of natural deep eutectic solvent extracted polysaccharides from Chinese yam peel using asymmetrical flow field-flow fractionation

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  24. Atmospheric Cold Plasma-Induced Interaction of Soy Protein Isolate/Dextran for Electrospraying and In Vitro Sustained Release of Acemannan Extracted from Aloe Vera Gel

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  34. Extraction-dependent structure–activity relationships of Panax quinquefolius L. polysaccharides: A comparative study

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