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RESEARCH PAPER · Biomaterials · 2025

STING-activating layered double hydroxide nano-adjuvants for enhanced cancer immunotherapy

Lirui Jia, Qin Yang, Xin Li, Hongzhuo Liu, Zhonggui He, Yongjun Wang

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23 direct citing papers in this saved network. Explore the next layer with second-order citations.

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STING-activating layered double hydroxide nano-adjuvants for enhanced cancer immunotherapyOriginalChrysanthemum-like Fe–Co LDH with peroxidase mimicking activity for visual and photothermal determination of H 2 O 2 and glucose1A Milestone in the Shift from “Passive Killing” to “Active Immunomodulation” in Cancer Treatment—Progress in Melanoma Vaccine Research7Engineered virus-derived platform enables glutathione depletion and cuproptosis for enhanced cancer immunotherapy1Layered double hydroxide-induced modulation of oxidative stress in disease therapy1Targeted delivery of okra polysaccharides to macrophages using a mannose-conjugated layered double hydroxide nanodelivery system1A NIR-Ⅱ-Immunostimulatory nanoplatform rewires immunometabolism to unleash STING-driven antitumor immunity0Targeting the cGAS–STING Pathway in Gastrointestinal Cancers: Modulating Tumor-associated Inflammation for Therapeutic Effect3Deciphering the immunomodulatory code: how metal nanoadjuvants orchestrate intracellular immune signaling cascades1Concept of 2D van der Waals Nanohybrids for Key Biomedical Applications3Dual Energy Depletion by Zinc/Copper Disruptor to Potentiate Cuproptosis and Pyroptosis for Enhanced Tumor Immunotherapy9Rational design of metal-based nanodrugs for cGAS-STING pathway activation: mechanisms, combinatorial therapies, and clinical translation2Engineering nanomedicine for STING pathway activation: Advancing cancer immunotherapy7STING-Activating Nanomedicines in Cancer Immunotherapy: Mechanisms, Design, and Therapeutic Outcomes4Emerging tumor therapies mediated by layered double hydroxides1Engineering ER-stress–driven immunogenic cell death with nanomedicine: UPR-axis control, DAMP signaling, and clinical translation1Ca2+-driven self-amplified nanoplatform targeting ER-mitochondrial calcium crosstalk for synergistic apoptosis induction and tumor immune microenvironment remodeling1Multifunctional nano-vaccines integrating lipid-conjugated tumor antigens with TLR/STING agonists enhance cancer immunotherapy0An Orthogonal Nanoadjuvant-Based RSV Subunit Vaccine Unlocks Potent Immunity through a High-Entropy-like Immunostimulatory Effect0Recent advances in precise synthesis, functional modification and multidisease theranostic applications of layered double hydroxide nanomaterials0Advances in research on layered double hydroxides for biomedical applications0Beyond Agonist Delivery: Metallic Nanomaterials as Active Regulators of cGAS-STING Signaling in Cancer Immunotherapy0Green Scalable Synthesis of Micrometer-Sized Hydrocalumite with Gas Barrier and UV Shielding Functions0Salvianic Acid A-Loaded Layered Double Hydroxide Nanosheets Boost T-Cell Infiltration through Tumor Vascular Normalization for Enhanced Immunotherapy0

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  1. Chrysanthemum-like Fe–Co LDH with peroxidase mimicking activity for visual and photothermal determination of H 2 O 2 and glucose

    Analytical Methods · 2025-01-01

    Youxiu Lin, Yangyang Chen, Jiangwei Huang, Dianping Tang, Wenqiang Lai

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  2. A Milestone in the Shift from “Passive Killing” to “Active Immunomodulation” in Cancer Treatment—Progress in Melanoma Vaccine Research

    Current Treatment Options in Oncology · 2025-07-17

    Yuke Zhang, Jie Liu, Xiyue Chang, Xuejing Yang, Xinyue Zhang, Wan’an Xiao

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  3. Engineered virus-derived platform enables glutathione depletion and cuproptosis for enhanced cancer immunotherapy

    Journal of Controlled Release · 2026-01-15

    Pengkai Wu, Xuesong Wu, Mengshuang Li, Xiaofei Yan, Miaoping Zhou, Guozheng Zhang, Xinjiang Yan, Tianqing Liu, Xisong Zhu, Xiaowei Han

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  4. Layered double hydroxide-induced modulation of oxidative stress in disease therapy

    Biomedicine & Pharmacotherapy · 2026-01-26

    Jun Wang, Ouyang Su, Zhaoxu Meng, Lili Lu, Yake Qi, Zonghui Zhang, Zhou Li, Xiu Dong, He Lian, Yiping Mu

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  5. Targeted delivery of okra polysaccharides to macrophages using a mannose-conjugated layered double hydroxide nanodelivery system

    International Journal of Biological Macromolecules · 2026-02-23

    Xuliang Liu, Qiyuan Luo, Yun Chen, Ping Jing Mo, Huricha Chen

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  6. A NIR-Ⅱ-Immunostimulatory nanoplatform rewires immunometabolism to unleash STING-driven antitumor immunity

    Journal of Nanobiotechnology · 2026-03-15

    Xun Yang, Xuefeng Chen, Maolin Chen, Simei Yang, Ya Wu, Hongye Liao, Tong Xia, Gaoyang Shen, Changzhen Sun, Li Liu

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  7. Targeting the cGAS–STING Pathway in Gastrointestinal Cancers: Modulating Tumor-associated Inflammation for Therapeutic Effect

    Current Drug Targets · 2026-03-15

    Heena Rathod, Parag Jain, Deepika Verma, Karan Kumar Dharme, Gyaneshwari Verma, Ajazuddin .

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  8. Deciphering the immunomodulatory code: how metal nanoadjuvants orchestrate intracellular immune signaling cascades

    Biochemical Pharmacology · 2026-03-26

    Lirong Fang, Yiting Zhao, Jieling Zhao, Canquan Mao, Yuhong Jiang

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  9. Concept of 2D van der Waals Nanohybrids for Key Biomedical Applications

    International Journal of Nanomedicine · 2026-04-01

    N. Sanoj Rejinold, Jin‐Ho Choy

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  10. Dual Energy Depletion by Zinc/Copper Disruptor to Potentiate Cuproptosis and Pyroptosis for Enhanced Tumor Immunotherapy

    ACS Nano · 2026-04-06

    Mofan Xiao, Junmin Qian, Weijun Xu, Yaping Wang, Jinlei Wang, Huichen Zhao, Xinyu Li, Lingyu Meng, Aili Suo

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  11. Rational design of metal-based nanodrugs for cGAS-STING pathway activation: mechanisms, combinatorial therapies, and clinical translation

    Coordination Chemistry Reviews · 2026-04-19

    Dian Chen, Aoyu Liu, Zirui Wang, Chunting Wang, Jingjing Hu, Dengbin Wang, Defan Yao

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  12. Engineering nanomedicine for STING pathway activation: Advancing cancer immunotherapy

    Journal of Controlled Release · 2026-04-26

    Zhilin Li, Hongbin Zhang, Qiyong Gong, Kui Luo

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  13. STING-Activating Nanomedicines in Cancer Immunotherapy: Mechanisms, Design, and Therapeutic Outcomes

    International Immunopharmacology · 2026-04-26

    Harshita Singhai, Urushi Rehman, Deena M. Bukhary, Garima Gupta, Umesh Kumar Patil, Amirhossein Sahebkar, Prashant Kesharwani

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  14. Emerging tumor therapies mediated by layered double hydroxides

    Coordination Chemistry Reviews · 2026-04-30

    Jie Wu, Zhicheng Liu, 裴寅清, Zifan Pei, Longxiao Li, Liang Cheng

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  15. Engineering ER-stress–driven immunogenic cell death with nanomedicine: UPR-axis control, DAMP signaling, and clinical translation

    Nano Today · 2026-04-30

    Naiyereh Alipour Eskandani, Maryam Ghasemzaei, Marzieh Ramezani Farani, Danial Mirzaee, Afrooz Hatami, Amir Ali Khosravi, Seyed Majid Ghoreishian, Yun Suk Huh

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  16. Ca2+-driven self-amplified nanoplatform targeting ER-mitochondrial calcium crosstalk for synergistic apoptosis induction and tumor immune microenvironment remodeling

    Materials Today Bio · 2026-06-10

    Yucui Ding, X LIU, Jianlong Fu, Jianyue Xue, Xueni Fan, Yundong Wang, Xinrui Li, Sirui Liu, Yanrong Yang, Xiaopeng Xu, Gangqiang Yang, Hongbo Wang, Peng Zhang

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  17. Multifunctional nano-vaccines integrating lipid-conjugated tumor antigens with TLR/STING agonists enhance cancer immunotherapy

    Cancer Letters · 2026-07-20

    Hari Krishnareddy Rachamala, Naga Malleswara Rao Nakka, Ramcharan Singh Angom, Fang Wei, Raj Nandani, Zain Toiemie, Edward Famularo, Shamit Kumar Dutta, Enfeng Wang, Santanu Bhattacharya, Krishnendu Pal, Keith L. Knutson, Debabrata Mukhopadhyay

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  18. An Orthogonal Nanoadjuvant-Based RSV Subunit Vaccine Unlocks Potent Immunity through a High-Entropy-like Immunostimulatory Effect

    Journal of the American Chemical Society · 2026-07-22

    L Chen, Yun Sun, Yuhang Dong, Yuqin Jin, Zibo Han, Ning Liu, X B Zheng, Shuai Shao, Junhua Zhang, Yu Liang, Mingtao Pu, Meijing Du, Qi Li, Guangjun Nie, Jin Ren, Feng Li

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  19. Recent advances in precise synthesis, functional modification and multidisease theranostic applications of layered double hydroxide nanomaterials

    Frontiers of Materials Science · 2026-09-01

    Yan Liu, Fang Li, Jingwen Peng, Lan Bao

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  20. Advances in research on layered double hydroxides for biomedical applications

    Smart Molecules · 2026-09-03

    Xinhui Yang, Zhiping Zhang, Zhao Wang, Hao Zhang, Yen Leng Pak, Yingying Jing, Yurong Guo, Fang Li, Xiao Wang, Quanxiang Han, Lei Ming Yu, Xuejiao Li, Xing Gao, Jibin Song

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  21. Beyond Agonist Delivery: Metallic Nanomaterials as Active Regulators of cGAS-STING Signaling in Cancer Immunotherapy

    ACS Nano Medicine · 2026-09-15

    Yunqi Guo, Zhihao Zhao, Liangcan He, Wei Tang

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  22. Green Scalable Synthesis of Micrometer-Sized Hydrocalumite with Gas Barrier and UV Shielding Functions

    Inorganic Chemistry · 2026-09-15

    Yutong Yang, Qian Liu, Huan Liu, Yinghan Guo, Yalin Shi, Dianqing Li, Fengrui Sun, Pinggui Tang

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  23. Salvianic Acid A-Loaded Layered Double Hydroxide Nanosheets Boost T-Cell Infiltration through Tumor Vascular Normalization for Enhanced Immunotherapy

    ACS Biomaterials Science & Engineering · 2026-09-22

    Yuxi Xiang, Junyu Tan, Xicheng Yan, Yunyun Wu, Chang YU, Daqing Xia, Jing Zhu, Hongrui Zhu, Jixi Zhang

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