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RESEARCH PAPER · Bone Research · 2025

Bone-brain interaction: mechanisms and potential intervention strategies of biomaterials

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Bone-brain interaction: mechanisms and potential intervention strategies of biomaterialsOriginalFascial Manual Medicine: The Concept of Fascial Continuum6Beyond the Brain: Exploring the multi-organ axes in Parkinson’s disease pathogenesis28Interactions among Substance use disorders, Inflammation, and Bone Health: a Crucial Role of the Brain-Bone Axis2Genomic structural equation modeling uncovers novel risk loci for bone metabolic disorders: cross-tissue genetic mechanisms and bone-brain axis regulation0Neurodegeneration as Ecosystem Failure: A New Paradigm for Prevention and Treatment9Molecular mechanisms and therapeutic implications of the sympathetic nervous system in bone-related disorders: a brain-bone axis perspective17Composite Ceramics Based on NaCaPO4 and Na4Ca4Si6O181Interorgan Communications in Skeletal Pathophysiology: From Molecular Pathways to Multidisciplinary Therapies1Multidimensional integrative analysis unveils genetic architecture, risk factors, and health consequences of brain aging0Integrative genomics establishes GNL3 as a pleiotropic hub and causal gene for osteoarthritis0Bidirectional interaction between the skeletal and nervous systems: a review0Aging brain, brittle bone0Gut-brain-joint axis in rheumatoid arthritis: from microeco-logical disturbance to multi-target synergy0Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone2Effects of exercise interventions on inflammatory biomarker levels in older adults with frailty and/or sarcopenia: a systematic review and meta-analysis0Association of estimated bone mass with cognitive function and physical performance in older adults with cognitive impairment: A cross-sectional study in Japan0Editorial: Application of stem cells in degenerative orthopedic diseases0Cognitive decline and reduced bone mineral density under the bone-brain axis: mechanistic insights and imaging evaluation strategies0Distinct Impacts of Somatic and Cognitive-Affective Depressive Symptom Trajectories on Osteoporosis Risk in Adults Aged 50 Years and Older0Activation of microglial PPARγ by asperosaponin VI alleviates stress-induced depression and synaptic impairment0Serum P1NP and magnesium levels in male patients with major depressive disorder: association with depression severity0Exploring the cognitive effects of arthritis: A Mendelian randomization study and cross-sectional analysis of NHANES data0Discovery of metabolites from Uvaria micrantha exhibiting anti-inflammatory and osteogenic potentials0Skeletal interoception regulates joint homeostasis and PGE2-induced pain: implication of disease-modifying treatment1RANKL-containing exosome-mediated bone-brain axis: a molecular hypothesis for post-fracture Dementia0Mechanisms of bone-brain axis involvement in concurrent nervous and skeletal system impairments associated with narcotic drug addiction: a review0ACE2 and Parkinsonism‑related bone metabolic alterations: signaling pathways and hub gene analysis0Exploratory bone–brain transcriptomic associations and an ODE-based digital-twin framework for fracture healing0Microgravity-Induced Osteocyte Dysfunction: An Osteocyte Mechanobiology Unit Framework0Neuro-immune interactions in tumors, immune-related disorders, and infections0Reprogramming pathological secretory phenotype of chondrocytes inhibits neurovascular invasion for osteoarthritis treatment0

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31 direct citing papers saved.

  1. Fascial Manual Medicine: The Concept of Fascial Continuum

    Cureus · 2025-04-12

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  2. Beyond the Brain: Exploring the multi-organ axes in Parkinson’s disease pathogenesis

    Journal of Advanced Research · 2025-05-16

    Tingting Liu, Haojie Wu, Jianshe Wei

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  3. Interactions among Substance use disorders, Inflammation, and Bone Health: a Crucial Role of the Brain-Bone Axis

    Current Addiction Reports · 2025-10-08

    Monika Martiniaková, Veronika Kováčová, Roman Bíro, Anna Šarocká, Noémi Pénzes, Vladimíra Mondočková, Radoslav Omelka

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  4. Genomic structural equation modeling uncovers novel risk loci for bone metabolic disorders: cross-tissue genetic mechanisms and bone-brain axis regulation

    BMC Musculoskeletal Disorders · 2025-11-17

    Yunqiao Zhou, Jian Huang, Leqin Xu, Fan Zhang, Chunxiao Bai, Fangyang Fan, Yuquan Wang, Bixuan Fang, Tianwei Wang, Xiaohong Mu, Jinyu Li

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  5. Neurodegeneration as Ecosystem Failure: A New Paradigm for Prevention and Treatment

    International Journal of Molecular Sciences · 2025-11-20

    Gordana S. Velikic, Gordana Šupić, Dušica Marić, Dušica Marić, Miljan Puletić, Maja Ovcak Kos, Danilo Vojvodić, Dusan M. Maric, Dusan M. Maric

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  6. Molecular mechanisms and therapeutic implications of the sympathetic nervous system in bone-related disorders: a brain-bone axis perspective

    Bone Research · 2025-12-02

    Mingdong Liu, Yaqi Liu, Jiayao Yu, Jiaqi Gong, Chunguang Zhao, Zheng Liu

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  7. Composite Ceramics Based on NaCaPO4 and Na4Ca4Si6O18

    Russian Journal of Inorganic Chemistry · 2026-01-01

    Maksim R. Kaimonov, Т. В. Сафронова, Ya. Yu. Filippov, Т. Б. Шаталова, Т. В. Филиппова, I. V. Kolesnik, S. A. Aleshin, V. V. Zaitseva

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  8. Interorgan Communications in Skeletal Pathophysiology: From Molecular Pathways to Multidisciplinary Therapies

    Research · 2026-01-01

    Donghao Gan, Lei Qin, Guozhi Xiao

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  9. Multidimensional integrative analysis unveils genetic architecture, risk factors, and health consequences of brain aging

    Journal of Advanced Research · 2026-02-01

    Yushu Huang, Zihan Li, Yuxin Yuan, Mengying Wang, Manrui Zhang, Zilin Li, Zilin Li, Xihao Li, Wenyuan Li

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  10. Integrative genomics establishes GNL3 as a pleiotropic hub and causal gene for osteoarthritis

    Human Genomics · 2026-02-16

    Tianhao Qu, Yan Zhong, Yonghuan Zhou, Lin Liu, Zheng Ye

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  11. Bidirectional interaction between the skeletal and nervous systems: a review

    Pediatric Traumatology Orthopaedics and Reconstructive Surgery · 2026-03-26

    Ходоровская Алина Михайловна, Olga Е. Agranovich, Margarita V. Savina, Yuriy E. Garkavenko, Evgenii V. Melchenko, Svetlana Ivanovna Trofimova, Ekaterina V. Petrova, Anna D. Dreval, Д. Б. Вчерашний

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  12. Aging brain, brittle bone

    Trends in Neurosciences · 2026-03-27

    Manyu Zhu, Aaron Watkins James

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  13. Gut-brain-joint axis in rheumatoid arthritis: from microeco-logical disturbance to multi-target synergy

    Journal of Zhejiang University (Medical Sciences) · 2026-04-01

    Shenlong Yi, Qiwang HE, Yanan LI, Bijiang WAN

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  14. Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone

    Advanced Science · 2026-04-13

    Charles A. Schurman, Gurcharan Kaur, Serra Kaya, Joanna Bons, Carlos Galicia Aguirre, Qi Liu, Christina D. King, Kenneth Anthony Wilson, Hazel Baker, Mikayla Hady, Nadja M. Maldonado Luna, Gregor Bieri, Saul Villeda, Lisa Ellerby, Birgit Schilling, Tamara N. Alliston

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  15. Effects of exercise interventions on inflammatory biomarker levels in older adults with frailty and/or sarcopenia: a systematic review and meta-analysis

    Frontiers in Immunology · 2026-04-30

    Rui Chu, Yeshou Xie, Wenchao Li, Yinuo Du, Tao Ni, Xinyu Tu, Baoru Xu, Junqing Zhao

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  16. Association of estimated bone mass with cognitive function and physical performance in older adults with cognitive impairment: A cross-sectional study in Japan

    Archives of Gerontology and Geriatrics Plus · 2026-05-01

    Derong Zeng, Jianghong Liu, Yuka Kanoya, Teruaki Kawasaki, Ichiro Akiguchi, Ayae Kinoshita

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  17. Editorial: Application of stem cells in degenerative orthopedic diseases

    Frontiers in Cell and Developmental Biology · 2026-05-08

    Jie Pan

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  18. Cognitive decline and reduced bone mineral density under the bone-brain axis: mechanistic insights and imaging evaluation strategies

    Frontiers in Aging Neuroscience · 2026-05-20

    Yunhai Mao, Zhe Sui, Mengchao Zhang, Y M

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  19. Distinct Impacts of Somatic and Cognitive-Affective Depressive Symptom Trajectories on Osteoporosis Risk in Adults Aged 50 Years and Older

    Clinical Gerontologist · 2026-05-20

    Chung-Chih Liao, Ke-Ru Liao, Jung-Miao Li

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  20. Activation of microglial PPARγ by asperosaponin VI alleviates stress-induced depression and synaptic impairment

    Journal of Advanced Research · 2026-06-01

    Yangyan Ge, Chengyan Yang, Meidan Wang, Pei Liu, Zhihuang Zhao, Haili Zhang, Shuqin Lu, Hui He, Yan Fu, Chenghong Xiao, Tao Zhou, Zili You, Jinqiang Zhang

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  21. Serum P1NP and magnesium levels in male patients with major depressive disorder: association with depression severity

    Romanian Journal of Psychiatry & Psychotherapy · 2026-06-30

    Rana Ali Jasim, Mohammed Imran Hamzah, Uday Khalid Abdul Jabbar Al Qaisy

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  22. Exploring the cognitive effects of arthritis: A Mendelian randomization study and cross-sectional analysis of NHANES data

    Medicine · 2026-07-17

    X F Wang, Linfang Deng, Tianyi Wang, Shaoting Luo

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  23. Discovery of metabolites from Uvaria micrantha exhibiting anti-inflammatory and osteogenic potentials

    Fitoterapia · 2026-08-07

    Szu‐Yin Yu, Hsin-Yi Tang, Yuh‐Chiang Shen, Wen‐Chi Wei, Chia‐Ching Liaw, Michal Kořínek, Quang-Vinh Nguyen, Chia‐Hung Yen, Yang‐Chang Wu, HY Chang, Kuang-I Cheng, Shyh‐Chyun Yang, Hao-Chun Hu, Fang‐Rong Chang

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  24. Skeletal interoception regulates joint homeostasis and PGE2-induced pain: implication of disease-modifying treatment

    Bone Research · 2026-08-13

    Qimiao Hu, Bonuo Qi, Yue Dong, Yushuang Pan, Yingjun Liu, Zhineng Chen, Jianqiao Fang, Yi Liang, Peng Zhang

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  25. RANKL-containing exosome-mediated bone-brain axis: a molecular hypothesis for post-fracture Dementia

    Medical Hypotheses · 2026-08-22

    Quanzhou Lv, Siqi Huang, Yuqi Ren, Shuyu Fan, Xinyu Yuan, Yan Li

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  26. Mechanisms of bone-brain axis involvement in concurrent nervous and skeletal system impairments associated with narcotic drug addiction: a review

    Journal of Zhejiang University (Medical Sciences) · 2026-09-01

    Yi YANG, Shuaixiong Liao, Tingran Zhang, Jiong LUO

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  27. ACE2 and Parkinsonism‑related bone metabolic alterations: signaling pathways and hub gene analysis

    Molecular Genetics and Genomics · 2026-09-09

    Tingting Liu, Yuheng Ren, Xinghua Tian, Jianshe Wei

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  28. Exploratory bone–brain transcriptomic associations and an ODE-based digital-twin framework for fracture healing

    Brain Research · 2026-10-01

    Chao Ma, Wei Lu, Ruipeng Guo

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  29. Microgravity-Induced Osteocyte Dysfunction: An Osteocyte Mechanobiology Unit Framework

    Current Osteoporosis Reports · 2026-10-03

    Arlyn M. Roque, Owen Brylle L. Acosta, Mary Jean R. Lozano, Hyacinth N. Suarez, Rommel G. Bacabac

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  30. Neuro-immune interactions in tumors, immune-related disorders, and infections

    Signal Transduction and Targeted Therapy · 2026-10-06

    Qing-Yuan Zhuang, Si-Wei Zhang, Zhi‐Ming Shao, Yi Xiao, Yi‐Zhou Jiang

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  31. Reprogramming pathological secretory phenotype of chondrocytes inhibits neurovascular invasion for osteoarthritis treatment

    Bioactive Materials · 2026-10-10

    Xiaonan Yuan, Yao Xiao, Cheng Chen, Youzhi Hong, Zhen Pan, Yang Zhang, Chao Wang, Jiale Chen, Yuan Chen, Feng Zhou, Liwei Yao, Lijie Wang, Haijiao Mao, Bin Li, Jiaying Li, Jinjin Ma

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