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RESEARCH PAPER · Nature Communications · 2024

Roboticized AI-assisted microfluidic photocatalytic synthesis and screening up to 10,000 reactions per day

Jia-Min Lu, Huifeng Wang, Qi-Hang Guo, Jianwei Wang, Tongtong Li, Kexin Chen, Mengting Zhang, Jianbo Chen, Qian-Nuan Shi, Yi Huang, Shao-Wen Shi, Guangyong Chen, Jian‐Zhang Pan, Zhan Ling Lu, Qun Fang

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Roboticized AI-assisted microfluidic photocatalytic synthesis and screening up to 10,000 reactions per dayOriginalRecent Advances in Machine Learning‐Assisted Multiscale Design of Energy Materials188Metal-free stereoselective intramolecular oxyamination of alkynes using a robotic and rapid photocatalytic synthesis and screening system6Experimental assessment of bulk vs microfluidic reactors for nano-bio-photocatalyst synthesis and antibiotic degradation1Advancing AI for science: From the revolution of tools to the tools for revolution3Autonomous laboratories in China: an embodied intelligence-driven platform to accelerate chemical discovery20BiOBr-based catalysts for photocatalytic nitrogen fixation: an overview from the perspective of structural design21Plasmonic copper nanoparticle aggregates for near-infrared light-driven hydrogen evolution5Thinking on the Use of Artificial Intelligence in Drug Discovery12Chat-microreactor: A large-language-model-based assistant for designing continuous flow systems13Physicochemical design of magneto-responsive confined interfaces for manipulation of nonmagnetic liquids1Artificial intelligence and machine learning for the optimization of photocatalytic performance11Machine learning-enabled optoelectronic material discovery: a comprehensive review31Intelligent chemical synthesis based on microchemical engineering technology2Perspective on Nano-Enabled Photostimulation Biointerfaces7From Micro to Marvel: Unleashing the Full Potential of Click Chemistry with Micromachine Integration4Artificial Intelligence‐Driven Approaches in Semiconductor Research44Microfluidic technology for cleaner production in microchemical engineering: design, fabrication and application panorama3The role of flow chemistry in self-driving labs19Application-Oriented Understanding of Spectroelectrochemistry: Perspective in the Realm of Electrochromism2Harnessing Synergies between Combinatorial Microfluidics and Machine Learning for Chemistry, Biology, and Fluidic Design6Research and Developments of Heterogeneous Catalytic Technologies20The role of artificial intelligence in optimizing photocatalytic degradation technologies of dyes in textile wastewater: Recent advances, challenges, and prospects13Transition Metal Chalcogenides for Wastewater Treatment1Synergy of Machine Learning and High‐Throughput Experimentation: A Road Toward Autonomous Synthesis8Synergy of robotics and microfluidics for intelligent micro- and nanomanipulation3Activation of Specific Reagents in Molecular Films by Sub-Ionization Electrons: Chlorobenzene/Water Films2Robot-assisted mapping of chemical reaction hyperspaces and networks15Rotary cylinder based fully integrated microfluidic system for the multiplex molecular diagnosis of respiratory pathogens5Harnessing Microfluidics for the Effective and Precise Synthesis of Advanced Materials12Next-generation photoelectrocatalysts: Real-time characterization and applications in sustainable energy and environment2ChemMiner: A Large Language Model Agent System for Chemical Literature Data Mining14Harnessing Solar Energy with Eco-Friendly InP Quantum Dots: A Review7Graphitic carbon nitride-based photocatalysts and sonocatalysts for energy and environment18Programmable Light-Driven Color Tuning of Perovskite Quantum Dots4Harnessing machine learning for energy optimization and intelligent process control in wastewater treatment1Building Catalyst Exploration Highways by Integrating High‐Throughput and Machine Learning Technologies11Advances in point-of-care testing based on microfluidic chips towards small molecular biomarkers9Overview of recent progress on metal-oxide-supported noble metals, nanocomposites, and carbon for photocatalytic water reduction1AI-guided precise design of antimicrobial polymers through high-throughput screening technology on an automated platform5Application and prospects of artificial intelligence in condensed matter structural chemistry0Autonomous microfluidic labs: progress and prospects7Closed-loop agentic AI in drug discovery1High-throughput screening and machine learning prediction of Rh-catalyzed ortho -C(sp 2 )–H amidation of arylaldehyde hydrazones0Machine learning-guided design principles for single-atom catalysts in persulfate-based advanced oxidation processes1Recent advances in green printing materials and technologies0Research Progress in Transition Metal-Catalyzed Asymmetric Hydroboration of 1,1-Disubstituted Alkenes0Micellization of Organic Conjugated Polymers toward Functional Nanomaterials for Photocatalytic Applications2Metalloprotein-Based Nanomedicines: Design Strategies, Functional Mechanisms, and Biomedical Applications1Advancing the modernization of traditional Chinese medicine through artificial intelligence and multimodal data integration10Research Progress in Artificial Intelligence-Assisted Preparation of High-Quality Biomaterials6Integrated end-to-end continuous-flow platform for the process intensification and kilogram-scale production of TADF emitters0Microfluidics: A Scalable Solution to Data Challenges in Chemical AI0AI-driven drug development: integrating computational design, 3D printing, and genomic medicine0Automatic Workflow for Chemical Reaction Data Processing: A Case Study of Suzuki Reactions0Accelerating Reaction Discovery through AI-HTE Integration: Nitrene-Mediated C–O Coupling as a Validated Case Study0Encapsulated droplet array for intensified micromole-scale high-throughput reaction screening0Robot-Assisted Study of a Near-Infrared Dye in Perovskite Solar Cells0Artificial intelligence in traditional Chinese medicine: From multimodal data integration to pharmacological research and clinical decision support0AI for science: Progress, challenges, and perspectives2Harnessing Machine Learning for Enzyme Enantioselectivity: Toward Intelligent Biocatalysis Engineering0Photothermal CO2 conversion using two-dimensional and porous framework materials: an energy-cascade analysis of mechanistically complementary catalysts0

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