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RESEARCH PAPER · ACS Sensors · 2024

Unleashing the Potential of Single-Atom Nanozymes: Catalysts for the Future

Eslam M. Hamed, Fun Man Fung, Sam Fong Yau Li

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Unleashing the Potential of Single-Atom Nanozymes: Catalysts for the FutureOriginalCopper Single‐Atom Nanozyme Mimicking Galactose Oxidase with Superior Catalytic Activity and Selectivity51Chrysanthemum-like Fe–Co LDH with peroxidase mimicking activity for visual and photothermal determination of H 2 O 2 and glucose1Graphene-based nanozymes for revolutionizing biomedical research21Zinc Single-Atom Nanozyme As Carbonic Anhydrase Mimic for CO2 Capture and Conversion32Nanozymes and the Sustainable Future of Food Quality Control: Innovation versus Pragmatism17Cationic carbon dots: A novel class of mimetic enzymes3Single‐Atom Iron Nanozyme‐based Colorimetric and Photothermal Dual‐Mode Sensor Array for Sulfur‐containing Metal Salts Identification8Smartphone-Based Bimetallic Single-Atom Nanozyme Sensor Array Integrated with Deep Learning for Rapid Biothiol Detection24Multifunctional nanozymes: Promising applications in clinical diagnosis and cancer treatment15Highly accessible Fe–N–C single-atom nanozymes with enhanced oxidase-like activity for smartphone-assisted colorimetric detection of uric acid14The Paradigm of Safe and Sustainable‐by‐Design Synthetic Catalysts for Catalytic Therapies1Cellulose-based carbon dots with fluorescence and oxidase-like activities: A tunable and sustainable substitute for natural enzymes to detect nitrite7The preparation of Arac-Cu nanozyme hydrogel with polyphenol oxidase-like activity for the rapid detection of tea polyphenol9Colorimetric detection of fluoroquinolones via MOF inhibition and thiol-response oxidase-mimicking reactions3Nanozyme-based synergistic therapy: FeCo-NC for effective bacterial eradication and wound tissue regeneration8Streamlined Synthesis of Ga‐Cu Dual Single‐Atom Nanozymes for Advanced Electrochemical Sensing Applications11Spatial Coordination Structure‐Driven Enzyme‐Like Selectivity in Single‐Atom Nanozymes54MXene‐Based Nanozymes: Current Challenges and Future Prospects11Chlorine Axial Coordination Enables Peroxidase Mimicking and Lignin Depolymerization in Fe–N3O Single-Atom Nanozymes12Bimetallic Cu/Zn Single‐Atom Nanozyme with Superoxide Dismutase‐Like Activity54Imitating Substrate Channels on a Mesoporous SiO2-Confined Fe1 Single-Atom Nanozyme for Enhancing Peroxidase-like Activity1Polyphenol Oxidase‐Like Nanozymes47Organic-Dominated Nanozymes for Pesticide Detection: Toward Sustainable Agricultural Monitoring25Enhanced multienzyme catalytic activity of Mn MOF induced by bioligands for efficient tumor therapy14Atomic-level regulation of the coordination structure in single-atom Fe nanozymes for tumor catalytic therapy11Single-Atom Nanozymes in Analytical Chemistry: Opportunities and Challenges43Metallothionein‐Inspired Asymmetric Heteroatom Doping of Single‐Atom Nanozymes for Multi‐Enzyme Biocatalysis7Bovine serum albumin-protected copper nanoclusters as a label-free biosensor for the discrimination of bacterial strains3A Spin‐Engineered Nanozyme Overcomes the Activity‐Selectivity Trade‐Off for Sustainable Adhesive Production From Lignin Biomass Conversion15Bimetallic Single-Atom Nanozyme with Enhanced Multienzyme-Mimicking Activity for Osteoarthritis Treatment via Reprogramming Inflammatory and Metabolic Microenvironment9Laccase-Inspired Single-Atom Fe–N 4 Nanozymes for Pollutant Degradation and Lignin Valorization8Nanozyme-enabled Sandwich-type colorimetric Aptasensor integrated with smartphone analysis for sensitive detection of low-density lipoprotein1The role of AI in the advancement of 2D materials for biosensing and nanoelectronics4Multifunctional copper–nitrogen/carbon laccase-mimicking nanozyme for colorimetric sensing of phenolic compounds and degradation of organic pollutants1Nanozymes as Biosensors and Nanomedicine0Iron single-atom nanozyme-mediated laser interstitial thermal therapy and anti-inflammatory effect for epilepsy1Polyphthalocyanine-based nanostructure for sono-immunotherapy by reprogramming the tumor microenvironment and blocking immune checkpoint3Advances and Challenges of Single-Atom Metals-Based Materials for Sensing Applications through Structure–Function Relationships0A Flexible Electrochemical Sensor Based on Fe/Ce Dual Single-Atom Nanozyme for Detection of Hydrogen Peroxide10Tailoring Ga Flexible Single-Atom Nanozymes for Self-Adaptive Catalytic Performance through Multienzyme Activity Switching12Nickel Single-Atom Nanozyme for Multimodal Cancer Therapy6Confined Synthesis of Axial Chlorine Coordinated Single-Atom Nanozyme Within Liposomes for Sensitive Immunoassay3Bioinspired single-atom copper nanozyme enables dual-mode colorimetric detection of ciprofloxacin and D-penicillamine3Application of Single-Atom Nanozymes in the Detection of Small Biomolecules: A Review4Coordination-Driven Design of Single-Atom Nanozymes: Bridging Mechanistic Insights and Multimetal Applications6Bridging the Gap Between Nanozyme Innovation and Real-World Environmental Solutions6Fe SA @Co NP Single-Atom Nanozyme with Tandem H 2 O 2 Production and Activation for Organic Dye Degradation without External Oxidants2Moving Beyond Fenton-Based Peroxidase Nanozymes for Analytical Sensing: Perspectives on Nonradical Alternatives from Heterogeneous Catalysis4Review of Single-Atom Nanozymes for Detection of Biomolecules, Pollutants, Microbes, and Food Additives0Synergistic dual-enzyme-like Cu/Os nanozymes enable multimodal biosensing platforms0Structure–activity regulation of confined AuPt nanozymes for a 3D-printed dual-mode point-of-care immunoassay1Atomically dispersed iron as catalase nanozyme towards biomimetic electrochemical detection of reactive oxygen species0Nanostructure Engineering of Ce(III) Species in Cerium Oxide/Polymeric Carbon Nitride Nanozymes for Simulated Oxidase Activities1Molecularly Imprinted Polymers for Biosensing: From Synthetic Recognition to Integrated Biointerfaces0Next-Generation Water Quality Monitoring via Artificial Intelligence-Coupled Nanozymes0

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  1. Copper Single‐Atom Nanozyme Mimicking Galactose Oxidase with Superior Catalytic Activity and Selectivity

    Small · 2024-09-09

    Eslam M. Hamed, Limo He, Varun Rai, Song Hu, Sam Fong Yau Li

    Read original paper ↗ ·

  2. Chrysanthemum-like Fe–Co LDH with peroxidase mimicking activity for visual and photothermal determination of H 2 O 2 and glucose

    Analytical Methods · 2025-01-01

    Youxiu Lin, Yangyang Chen, Jiangwei Huang, Dianping Tang, Wenqiang Lai

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  3. Graphene-based nanozymes for revolutionizing biomedical research

    RSC Advances · 2025-01-01

    Astha Tripathi, Saumya Singh Rautela, Pratibha Kumari

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  4. Zinc Single-Atom Nanozyme As Carbonic Anhydrase Mimic for CO2 Capture and Conversion

    ACS Materials Au · 2025-01-31

    Eslam M. Hamed, Fun Man Fung, Sam Fong Yau Li

    Read original paper ↗ ·

  5. Nanozymes and the Sustainable Future of Food Quality Control: Innovation versus Pragmatism

    ACS Food Science & Technology · 2025-02-25

    Eslam M. Hamed, Fun Man Fung, Sam Fong Yau Li

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  6. Cationic carbon dots: A novel class of mimetic enzymes

    Nano Research · 2025-02-28

    Xin Wu, Zhuang Tong, Yunliang Liu, Yi Yang, Yaxi Li, Yuanyuan Cheng, Jingwen Yu, Naiyun Liu, Chanyuan Jin, Haitao Li

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  7. Single‐Atom Iron Nanozyme‐based Colorimetric and Photothermal Dual‐Mode Sensor Array for Sulfur‐containing Metal Salts Identification

    ChemNanoMat · 2025-03-11

    Can Wang, Lifeng Wang, Wendong Liu, Zhipeng Xu, Yizhong Lu

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  8. Smartphone-Based Bimetallic Single-Atom Nanozyme Sensor Array Integrated with Deep Learning for Rapid Biothiol Detection

    ACS Applied Nano Materials · 2025-03-12

    Jiawei Wang, Zhuohang Huang, Xiaomeng Yu, Bin Zhou, Wenjie Xu, Xi Zhou, Zhiwei Chen

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  9. Multifunctional nanozymes: Promising applications in clinical diagnosis and cancer treatment

    Biosensors and Bioelectronics · 2025-03-22

    Hailin Yin, Xin Yuan Yang, Jiaying Yang, Qian Luo, Mei Yang, Jicheng Sun, Yingtong Wang, Qi Wang, Dhan V. Kalvakolanu, Baofeng Guo, Wei Jiang, Ling Zhang

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  10. Highly accessible Fe–N–C single-atom nanozymes with enhanced oxidase-like activity for smartphone-assisted colorimetric detection of uric acid

    Talanta · 2025-04-04

    Dan Xu, Fang Yang, Yu Ou, Qiumei Pu, Qian Chen, Hua Pei, Binwen Huang, Qiang Wu, Yuanyuan Wang

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  11. The Paradigm of Safe and Sustainable‐by‐Design Synthetic Catalysts for Catalytic Therapies

    ChemCatChem · 2025-04-07

    Esteban Zingales, Claudia Miranda-Pérez de Alejo, Manu Sánchez, Laura Fernández‐Méndez, Jesús Ruı́z-Cabello, Carlos Sánchez-Cano, Susana Carregal‐Romero

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  12. Cellulose-based carbon dots with fluorescence and oxidase-like activities: A tunable and sustainable substitute for natural enzymes to detect nitrite

    Bioresource Technology · 2025-04-08

    Pengyu Hu, Yunchuan Dai, Tingting Chu, Jiliang Ma, Xing Wang, Zhiwei Wang, Pedram Fatehi, Yanzhu Guo

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  13. The preparation of Arac-Cu nanozyme hydrogel with polyphenol oxidase-like activity for the rapid detection of tea polyphenol

    Journal of Food Composition and Analysis · 2025-04-26

    Jie Li, Zhichun Bi, Zhichun Bi, Yu Ma, Linxue Zhen, Hui Sheng Huang, Yunfei Xie, Yunfei Xie

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  14. Colorimetric detection of fluoroquinolones via MOF inhibition and thiol-response oxidase-mimicking reactions

    Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · 2025-05-05

    Wenzhi Zhang, Song Liu, Henggang Wang, Zhe Wang, Zhe Wang, Linfeng Cui, Nian Fu, Zhenguang Wang, Zhenguang Wang

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  15. Nanozyme-based synergistic therapy: FeCo-NC for effective bacterial eradication and wound tissue regeneration

    Journal of Colloid and Interface Science · 2025-06-11

    Xiaolong Zhu, Wei Lü, Ziyi Li, Jiamu Xiao, Donglin Gan, Xuefeng Jiang, Mingqian Wang

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  16. Streamlined Synthesis of Ga‐Cu Dual Single‐Atom Nanozymes for Advanced Electrochemical Sensing Applications

    Advanced Functional Materials · 2025-06-16

    Guangchun Song, Xiaochun Zheng, Zedong Zhang, Marie‐Laure Fauconnier, Li Cheng, Chen Li, Dequan Zhang

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  17. Spatial Coordination Structure‐Driven Enzyme‐Like Selectivity in Single‐Atom Nanozymes

    Advanced Materials · 2025-07-02

    Qijun Sun, Si Liu, Ziping Li, Peiji Deng, Na Niu, Ligang Chen, Kang Liang

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  18. MXene‐Based Nanozymes: Current Challenges and Future Prospects

    ChemCatChem · 2025-07-03

    Eleonora Pargoletti, Yury G. Gogotsi

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  19. Chlorine Axial Coordination Enables Peroxidase Mimicking and Lignin Depolymerization in Fe–N3O Single-Atom Nanozymes

    ACS Applied Materials & Interfaces · 2025-07-16

    Qifeng Li, Wenzhi Jiang, Xiaoling Wu, Hongming Lou, Xueqing Qiu, Zhixian Li

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  20. Bimetallic Cu/Zn Single‐Atom Nanozyme with Superoxide Dismutase‐Like Activity

    Small · 2025-07-20

    Eslam M. Hamed, Fun Man Fung, Sam Fong Yau Li

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  21. Imitating Substrate Channels on a Mesoporous SiO2-Confined Fe1 Single-Atom Nanozyme for Enhancing Peroxidase-like Activity

    ACS Applied Nano Materials · 2025-07-22

    Zhiyu Yin, Jiaxin Lv, Man Yang, Rui Zhang, Huifeng Xiong, Jingwen Wang, Dan Feng, Yujing Ren

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  22. Polyphenol Oxidase‐Like Nanozymes

    Advanced Materials · 2025-08-23

    Haolun Gu, Jingqi Li, Pengyu Dai, Tiedong Sun, Chunxia Chen, Zhong Guo, Kelong Fan

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  23. Organic-Dominated Nanozymes for Pesticide Detection: Toward Sustainable Agricultural Monitoring

    Journal of Agricultural and Food Chemistry · 2025-08-26

    Eslam M. Hamed, Kustomo Kustomo, Mostafa M. Elsaady, Xiaoli Wu, Fun Man Fung, Sam Fong Yau Li

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  24. Enhanced multienzyme catalytic activity of Mn MOF induced by bioligands for efficient tumor therapy

    Journal of Nanobiotechnology · 2025-09-26

    Junfeng Ke, Yuxin Tian, Tongjia Zhang, Anran Li, You Zhou, Yifan Cao, Liping Wang

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  25. Atomic-level regulation of the coordination structure in single-atom Fe nanozymes for tumor catalytic therapy

    Journal of Colloid and Interface Science · 2025-09-29

    Xinyu Gao, Yang Guo, Sihan Wang, Jingting Li, Hao Xin, Zihan Zhou, Fan Yang, Mingyu Nie, Fei Song, Yutao Wang, Changsong Dai, Zhaohui Wen

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  26. Single-Atom Nanozymes in Analytical Chemistry: Opportunities and Challenges

    Analytical Chemistry · 2025-10-17

    Eslam M. Hamed, Mostafa M. Elsaady, Sam Fong Yau Li

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  27. Metallothionein‐Inspired Asymmetric Heteroatom Doping of Single‐Atom Nanozymes for Multi‐Enzyme Biocatalysis

    Advanced Science · 2025-11-03

    Kaijuan Chen, Qianfan Chen, Bernt Johannessen, Chun‐Ho Lin, Long Hu, Kang Liang, Jieying Liang

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  28. Bovine serum albumin-protected copper nanoclusters as a label-free biosensor for the discrimination of bacterial strains

    Scientific Reports · 2025-11-18

    Saad Megahed, Noha El Salakawy, Wael Mamdouh

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  29. A Spin‐Engineered Nanozyme Overcomes the Activity‐Selectivity Trade‐Off for Sustainable Adhesive Production From Lignin Biomass Conversion

    Advanced Materials · 2025-11-26

    Yixin Yu, Ran Xu, Xuetong Wu, Bilian Wang, Mingzhen Zhang, Kelong Fan

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  30. Bimetallic Single-Atom Nanozyme with Enhanced Multienzyme-Mimicking Activity for Osteoarthritis Treatment via Reprogramming Inflammatory and Metabolic Microenvironment

    ACS Applied Materials & Interfaces · 2025-11-26

    Lixin Ma, Qiqi Zhang, Jueshuo Guo, Peng Li, Penglong Ma, Ting Gao, Guojing Gou, Jianhong Yang, Wenbao Zuo

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  31. Laccase-Inspired Single-Atom Fe–N 4 Nanozymes for Pollutant Degradation and Lignin Valorization

    Langmuir · 2025-12-01

    Yingjin Ma, Qifeng Li, Xueqing Qiu, Zhixian Li

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  32. Nanozyme-enabled Sandwich-type colorimetric Aptasensor integrated with smartphone analysis for sensitive detection of low-density lipoprotein

    Microchemical Journal · 2025-12-11

    Zhide Zhou, Tingting Yu, Yu Zhou, Xiaohong Tan, Zhanhua Su, Jintao Liang, Guiyin Li

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  33. The role of AI in the advancement of 2D materials for biosensing and nanoelectronics

    Journal of Materials Chemistry A · 2025-12-23

    Salah Ud Din, Chen UD Peng, Muhammad Kamran Shereen, Sufaid Shah, Liu xianlong, Matin Ashurov, Zecheng Ren, Jinxuan Liang

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  34. Multifunctional copper–nitrogen/carbon laccase-mimicking nanozyme for colorimetric sensing of phenolic compounds and degradation of organic pollutants

    Inorganic Chemistry Frontiers · 2026-01-01

    Xu Liu, Hongtian Stanley Yang, Yide Han, Ying Liu, Ying Zhang, Wenhao Li, Xia Zhang

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  35. Nanozymes as Biosensors and Nanomedicine

    Elsevier eBooks · 2026-01-01

    Shao‐Bin He, Qionghua Zheng, Ruofei Zhang, Long Ma, Wei Chen, Kelong Fan

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  36. Iron single-atom nanozyme-mediated laser interstitial thermal therapy and anti-inflammatory effect for epilepsy

    Materials Today Bio · 2026-01-18

    Xiao-Dan Zhang, Yu Tian, Jing Ma, Wei Lei, Weijie Yu, Penghui Liu, Wen Huang, Wei Huang, Ren-Fu Liu, Xiang-Tao Zhang, Feng Wang, Yang Zhu, Yuan-Xiang Lin

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  37. Polyphthalocyanine-based nanostructure for sono-immunotherapy by reprogramming the tumor microenvironment and blocking immune checkpoint

    Chemical Engineering Journal · 2026-02-01

    Lingfeng Jiang, Jiawei Wang, Wenjun Liu, Xin Xie, Xiao Luo, Ling Tu, Liangqing Tang, Qing Zhang, Hongmei Yuan, Hanfeng Yang, Qi Li, Qi Li, Sujiao Cao, Sujiao Cao, Ling Li

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  38. Advances and Challenges of Single-Atom Metals-Based Materials for Sensing Applications through Structure–Function Relationships

    ACS Applied Nano Materials · 2026-02-17

    Chaorui Li, Yajun Gao, Li Li, Jie Liu, Jun Yang

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  39. A Flexible Electrochemical Sensor Based on Fe/Ce Dual Single-Atom Nanozyme for Detection of Hydrogen Peroxide

    ACS Applied Materials & Interfaces · 2026-03-03

    Sifan Sun, Jiawei Li, Qianzuo Liu, Binqi He, Haoran Yang, Xinyue Xiang, Y. Hao, Xiaoli Yan, Ting Zhang, Tie Li

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  40. Tailoring Ga Flexible Single-Atom Nanozymes for Self-Adaptive Catalytic Performance through Multienzyme Activity Switching

    Journal of the American Chemical Society · 2026-03-16

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  41. Nickel Single-Atom Nanozyme for Multimodal Cancer Therapy

    ACS Applied Materials & Interfaces · 2026-03-18

    J.I. Woo, Hojeong Shin, Seongin Hong, Hyeonwoo Cho, Byung Hee Hong, Yun Jeong Hwang, Dal‐Hee Min

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  42. Confined Synthesis of Axial Chlorine Coordinated Single-Atom Nanozyme Within Liposomes for Sensitive Immunoassay

    Nano-Micro Letters · 2026-03-19

    Chenchen Chu, Mingyang Jiang, Yubei Zhang, Kun Feng, Chaolei Hua, Lie Wu, Yijie Chen, Ling Ji, Xitong Gao, Xue‐Feng Yu, Shengyong Geng, Wenhua Zhou

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  43. Bioinspired single-atom copper nanozyme enables dual-mode colorimetric detection of ciprofloxacin and D-penicillamine

    Food Bioscience · 2026-04-07

    Siyi Liu, Mingqin Kang, Zhongping Dong, Shuyan Xiao

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  44. Application of Single-Atom Nanozymes in the Detection of Small Biomolecules: A Review

    Molecules · 2026-04-09

    Wenxiao Zhang, Rong Ying Huang, Wenhui Luo, Xiaojing Si, Dongmei Deng, Liqiang Luo

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  45. Coordination-Driven Design of Single-Atom Nanozymes: Bridging Mechanistic Insights and Multimetal Applications

    Accounts of Materials Research · 2026-05-04

    Eslam M. Hamed, Yanyan Zhu, Fun Man Fung, Sam Fong Yau Li

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  46. Bridging the Gap Between Nanozyme Innovation and Real-World Environmental Solutions

    Analytical Chemistry · 2026-05-18

    Eslam M. Hamed, Sam Fong Yau LI

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  47. Fe SA @Co NP Single-Atom Nanozyme with Tandem H 2 O 2 Production and Activation for Organic Dye Degradation without External Oxidants

    ACS ES&T Engineering · 2026-05-18

    Mostafa M. Elsaady, Eslam M. Hamed, Sam Fong Yau Li

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  48. Moving Beyond Fenton-Based Peroxidase Nanozymes for Analytical Sensing: Perspectives on Nonradical Alternatives from Heterogeneous Catalysis

    Analytical Chemistry · 2026-06-01

    Bo Yuan, Yifan Cui, Pi‐Tai Chou, Yung‐Kang Peng

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  49. Review of Single-Atom Nanozymes for Detection of Biomolecules, Pollutants, Microbes, and Food Additives

    ACS Applied Nano Materials · 2026-06-25

    Li Zhang, Liu R, Yao Tian, Yaoyong Wang, Wei Bian

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  50. Synergistic dual-enzyme-like Cu/Os nanozymes enable multimodal biosensing platforms

    Microchemical Journal · 2026-06-25

    Qionghua Zheng, Liangming Wang, Xiaoyun Guo, Yebin Feng, J Chen, Yin Zhang, Qi Zhang, Shao‐Bin He, Wei Chen

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