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RESEARCH PAPER · Materials Today Bio · 2024

AI energized hydrogel design, optimization and application in biomedicine

Zuhao Li, Peiran Song, Guangfeng Li, Yafei Han, Xiaoxiang Ren, Long Bai, Jiacan Su

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AI energized hydrogel design, optimization and application in biomedicineOriginalArtificial intelligence for life sciences: A comprehensive guide and future trends48Integrating machine learning for the optimization of polyacrylamide/alginate hydrogel42Multifunctional hydrogel-based engineered extracellular vesicles delivery for complicated wound healing60Multifunctional hydrogels-based therapies for chronic diabetic wound healing71Novel Functional Dressing Materials for Intraoral Wound Care40Dual cross-linked self-healing hydrogel enhanced by dopamine nanoparticles and raffinose for wound healing14Deep learning for predicting synergistic drug combinations: State‐of‐the‐arts and future directions18Advances in neuronal regeneration: Hydrogel-based delivery systems loaded with extracellular vesicles in modulating neural impulses and tissue repair6Organoids: development and applications in disease models, drug discovery, precision medicine, and regenerative medicine90Recent advancements in nanozyme hydrogel based system for enhanced sensing applications11MMP-9 responsive hydrogel promotes diabetic wound healing by suppressing ferroptosis of endothelial cells68Recent advances in 3D bioprinted polysaccharide hydrogels for biomedical applications: A comprehensive review65Temperature-Responsive Injectable Composite Hydrogels Based on Poly(N-Isopropylacrylamide), Chitosan, and Hemp-Derived Cellulose Nanocrystals19Advances in Injectable Polymeric Biomaterials and Their Contemporary Medical Practices17Artificial intelligence powers regenerative medicine into predictive realm19Progress of AI assisted synthesis of polysaccharides-based hydrogel and their applications in biomedical field23Scalable Accelerated Materials Discovery of Sustainable Polysaccharide-Based Hydrogels by Autonomous Experimentation and Collaborative Learning6An artificial intelligence-driven revolution in orthopedic surgery and sports medicine27Additively manufactured hydrogels: recent developments and future perspectives0Artificial intelligence-enabled hydrogels: innovations and applications33CNC-mediated functionalized MWCNT-reinforced double-network conductive hydrogels as smart, flexible strain and epidermic sensors for human motion monitoring37Future Scopes of Hydrogels-Based Wound Healing0Hydrogels for cardiac tissue regeneration0Perspectives and future scope of hydrogels in regenerative medicine and tissue engineering0Recent progress in multifunctional theranostic hydrogels: the cornerstone of next-generation wound care technologies32Revisiting the biophysical aspects of extracellular-matrix-mimicking hydrogels: what cells see vs. what cells feel30ROS scavenging Mn3O4 nanozyme regulated immune microenvironment and affects intercellular interaction to promote wound healing in diabetes16The synergy of artificial intelligence in biomaterials, regenerative medicine and drug delivery2Unveiling the development principles and mechanistic understanding of controlled drug delivery strategies for chronic bone defects and diabetic wound management4Tumor microenvironment as a target for developing anticancer hydrogels7Development and application of geothermally derived silica grout for carbon-neutral soil stabilization1Artificial Intelligence Enabled Biomineralization for Eco‐Friendly Nanomaterial Synthesis: Charting Future Trends56Environmental stimuli‐responsive hydrogels in endodontics: Advances and perspectives19Revolutionizing prostate cancer therapy: Artificial intelligence – Based nanocarriers for precision diagnosis and treatment53Engineered hydrogel platform for diabetic wound healing43Bioactive hydrogel formulations for regeneration of pathological bone defects42Advances in Starch-Based Nanocomposites for Functional Food Systems: Harnessing AI and Nuclear Magnetic Resonance Technologies for Tailored Stability and Bioactivity23Hierarchical Engineering for Biopolymer‐based Hydrogels with Tailored Property and Functionality62Smart biomaterials in healthcare: Breakthroughs in tissue engineering, immunomodulation, patient-specific therapies, and biosensor applications39Evolving biomaterials design from trial and error to intelligent innovation29Biomimetic structural design in 3D-printed scaffolds for bone tissue engineering85Innovative approaches in bioadhesive design: A comprehensive review of crosslinking methods and mechanical performance7Plant Polyphenol‐Based Injectable Hydrogels: Advances and Biomedical Applications29Additive manufacturing in biomedical: Applications, challenges, and prospects36Tough, Wide-Temperature-Resistant, and Water-Retentive Conductive Hydrogel for Human Motion Sensing5IA-DTPSO: A Multi-Strategy Integrated Particle Swarm Optimization for Predicting the Total Urban Water Resources in China1Neem gum and its derivatives as potential polymeric scaffold for diverse applications: a review5DNA Hydrogels in Tissue Engineering: From Molecular Design to Next‐Generation Biomedical Applications27Exploring factors that influence graduate students’ intention to use generative artificial intelligence in academic research: PLS-SEM and fsQCA methods9Recent Progress in Cellulose-Based Conductive Hydrogels24Mathematical modeling of swelling and shrinking dynamics in pH-sensitive hydrogels composed of alginate, anionic cellulose, and chitosan11Artificial Intelligence tool for prediction of ECM mimics hydrogel formulations via click chemistry31Next-Generation Transformable Nanomedicines: Revolutionizing Cancer Drug Delivery and Theranostics11Leveraging Instabilities in Multifunctional Soft Materials: A Cutting Edge Review3Rapamycin-induced small extracellular vesicles under GelMA scaffolds facilitate diabetic wound repair through accelerating angiogenesis and alleviating macrophage-mediated inflammation via PI3K/Akt signaling pathway9Next-Generation Hydrogel Design: Computational Advances in Synthesis, Characterization, and Biomedical Applications46Media Polarity Control Strategy to Tailor Mechanical Behavior of Dual Monomer Single Network Hydrogels and Integrated Machine Learning Approach1Immunomodulatory hydrogel loaded with PD-L1-expressing exosomes reprograms macrophages and accelerates diabetic wound healing17Recent Advancements in Smart Hydrogel-Based Materials in Cartilage Tissue Engineering23Advancing microneedle technology for multiple distinct target organs drug delivery through 3D printing: a comprehensive review22Artificial Intelligence for Organoids Multidimensional Assessment24Multimodal AI in Biomedicine: Pioneering the Future of Biomaterials, Diagnostics, and Personalized Healthcare109Artificial intelligence and machine learning-driven design of self-healing biomedical composites18Dynamic bioinks for tissue/organ bioprinting: Principle, challenge, and perspective22Bioinspired multifunctional antifogging surfaces: Progress, AI design and challenges14Artificial intelligence-assisted next-generation biomaterials: From design and preparation to medical applications29Advancements in Hydrogels: A Comprehensive Review of Natural and Synthetic Innovations for Biomedical Applications271Machine Learning in Gel-Based Additive Manufacturing: From Material Design to Process Optimization44Unveiling the Pathological Landscape of Intrauterine Adhesion: Mechanistic Insights and Exosome-Biomaterial Therapeutic Innovations28Artificial intelligence in orthopedics: fundamentals, current applications, and future perspectives19Printed Sensors for Environmental Monitoring: Advancements, Challenges, and Future Directions33Polymeric thermogels: Fundamentals and strategies for their rational design10Data-driven de novo design of super-adhesive hydrogels160Artificial Intelligence‐Driven Nanoarchitectonics for Smart Targeted Drug Delivery107Advanced strategies in medicinal plant polysaccharide-based hydrogels for diabetic foot ulcer healing: A review6Hydrogel‐Based Therapeutics for Diabetic Oral Wounds: From Mechanisms to Applications8An MA-film platform designed for high-throughput synthesis of calcium phosphates screening amino acid on collagen film0Recent advances in hydrogel-based drug delivery systems for enhanced cancer therapy: A review20Tailoring Therapy: Hydrogels as Tunable Platforms for Regenerative Medicine and Cancer Intervention15Prediction of accelerated cooling rates in H-section steels using artificial neural networks5Engineering the Beating Heart: Cardiac Organoid Models for Tissue Regeneration0Inflammation-Responsive Hydrogels in Perioperative Pain and Wound Management: Design Strategies and Emerging Potential21Biological Models for Evaluating Hydrogel-Based Formulations in Wound Healing10Application and development prospects of bio-based smart responsive hydrogels in insulin delivery3Functional Hydrogels: A Promising Platform for Biomedical and Environmental Applications15Organoid‐based novel technology for antitumor drug screening5Cell-free systems for low-cost diagnostics0A Review inside Innovation: AI and Additive Manufacturing for Advanced Bone Scaffold Design10Transformative applications of artificial intelligence in lithium battery materials science: advancements and future prospects0Skin Relevant Biomaterials from Wound Healing, Medical Aesthetics, Flexible Electronics to Artificial Intelligence and Beyond35The emerging role of ChatGPT in cancer and burn research: Applications in wound healing and regenerative medicine0Bioengineered In Situ-Forming Hydrogels as Smart Drug Delivery Systems for Postoperative Breast Cancer Immunotherapy: From Material Innovation to Clinical Translation19AI-based optimization of cutting parameters for tool wear and surface roughness of machined specimens1The emerging role of machine learning in nanomaterials research: applications, challenges, and future directions8AI-enhanced surface functionalization in biosensors: From fundamentals to future prospects6Pharmaceutical 3D Printing for Psychiatric Medications: Advanced Innovations in Taste Masking and Personalized Oral Drug Delivery5Smart hydrogels for tissue engineering and regenerative medicine: how far have we come14Multicriteria Optimization of Nanocellulose-Reinforced Polyvinyl Alcohol and Pyrrolidone Hydrogels2Hydrogels for Bone Regeneration: Properties, Additives, Preclinical and Clinical Applications14Hydrogel Films in Biomedical Applications: Fabrication, Properties and Therapeutic Potential24Smart bioactive hydrogels for myocardial infarction repair: a multifunctional approach integrating stimuli-responsive drug delivery, electroconductivity, and real-time biosensing8Ionic–Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy17Hydrogels for Analyte Sensing7Intelligent Sensing: The Emerging Integration of Machine Learning and Soft Sensors Based on Hydrogels and Ionogels25Can bionic eyes restore vision? Breakthroughs, challenges, and future frontiers in ophthalmology – A comprehensive review16Hydrogel-Based Biomaterials in Spinal Repair: Evaluating Mechanisms for IVDD, SCI, and Dural Regeneration1Preparation and biomedical application of light-responsive hydrogels based on natural products8Artificial intelligence in biopolymer design and engineering2Intelligent tools for biomaterials design0Biocompatible Stimuli-Sensitive Natural Hydrogels: Recent Advances in Biomedical Applications36Cold Sintering of Hydrogels: Opportunities and Roadmap for a Nascent Field3Antibacterial Agent‐Loaded Hydrogels for Implant‐Associated Osteomyelitis: A Review4Mechanically adaptive hydrogels for bone tissue engineering: from classification and biomechanics to modeling and translational applications7Biodegradable polymeric nanosystems in management of skin cancer1Design Considerations, Formulation Approaches, and Strategic Advances of Hydrogel Platforms for Tendinopathy Management2The Impact of Biomedical Intelligence on Public Health0What role might nanolipogels play in enhancing drug delivery?0Antifreeze high stretch ion-conducting hydrogels and their application in flexible devices2Applications of Stimuli‐Responsive Hydrogels in Renewable Energy: A Review6Bionic ion skin multimodal system for advanced epidermal electronics2Concluding remarks and outlook on nanomedicine’s transformative potential in oncology0Enzyme-responsive smart hydrogels for controlled drug delivery: design strategies and translational perspectives1Noncoding RNAs in chronic wound healing: Mechanisms, exosome therapeutics, and translational frontiers4Physicochemical foundations of biotribological biomaterials: Design, performance, and future horizons0Smart Hydrogels Empowering Tissue Repair: Material Design, Emerging Applications, Repair Mechanisms, and Future Challenges0Smart natural polymer-based hydrogels for chronic wound management: advances in real-time monitoring and stimuli-responsive therapy7Stimuli-responsive hydrogels for radiation-induced skin injury: from passive barriers to autonomous drug delivery systems2Tailored injectable nanocomposite hydrogels for high-performance biomedical applications0Targeting delayed healing tissues: immune reprogramming of adaptive immune cells by biomaterials6Translational significance of artificial intelligence in cardio and neurovascular drug delivery0Injectable hydrogels for bone regeneration: mechanical reinforcement strategies using nanoparticles and nanofibers3Hydrogel-Based Bioelectronics0Advances in biomaterials for medical textile applications: a review on integration strategies and sustainable innovations1Artificial intelligence & machine learning in hydrogel: Revolutionizing design and optimization – detailed review20Alginate-based encapsulation: from historical evolution to AI-driven optimization for sustainable innovations4Revolutionizing endodontics: the impact and innovations of artificial intelligence6Hydrogels for Cancer Immunotherapy: Strategies From Construction to Application5Recent Advances in Integrating Graphene into Polymeric Nanocomposite Hydrogels for Biomedical Applications8Integrating 3D Bioprinting and AI in Healthcare2A review on novel materials in optical waveguide sensors: opportunities and challenges for the next decade3Food-derived self-assembling peptide hydrogels: Mechanistic insights, food applications, and AI-driven future perspectives5Shape Memorable and Self‐Healable Smart Hydrogels and Emerging Directions6Hydrogel Beads-based drug delivery systems rheumatoid arthritis1Research Progress in Artificial Intelligence-Assisted Preparation of High-Quality Biomaterials6Novel AI-Driven Precision Strategies in Diabetic Wound Healing: Immunomodulation and Advances in Smart Composite Nanocarriers6The Synthetic Extracellular Matrix as a Maestro of the In Vitro Stem Cell Niche: Orchestrating Fate and Function4409Chapter 14 Integrating Artificial Intelligence with Bioprinting: Smart Design and Optimization of Tissue Constructs0Exosome-enabled bone defect repair: mechanistic foundations, bioengineered delivery, and artificial intelligence-driven translation6Intelligent self-healing hydrogels: AI-Empowered design, biomedical innovation, and future horizons3Ultra-stretchable, tough, and crack-resistant polyoxometalates-composited hydrogels for wearable sensors5

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