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RESEARCH PAPER · Crystal Growth & Design · 2022

New Case of Pharmaceutical Solid-State Forms: Several Novel Solvates/Polymorphs of Nilotinib and Their Phase Transformation Controls

Xiangjun Shi, Qi‐Feng Chen, Yu Deng, Xiaoyi Xing, Chao Wang, Zejie Ding, Weike Su

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New Case of Pharmaceutical Solid-State Forms: Several Novel Solvates/Polymorphs of Nilotinib and Their Phase Transformation ControlsOriginalSynthetic Strategies toward Higher Cocrystals of Some Resorcinols25Polymorph Screening of the Antitumor Drug Ripretinib─Selective Preference of Dimer Synthons10Two new nilotinib polymorphs with solubility advantages prepared by the melt crystallization process17Optimization of precipitation conditions for producing physically stable amorphous solids using pair distribution function and reduced crystallization temperature6Polymorph transformation of solid drugs and inhibiting strategies11Crystal Structure of Nilotinib Hydrochloride Monohydrate According to Powder X-Ray Diffraction Data6Investigation of the Influence of Anti-Solvent Precipitation Parameters on the Physical Stability of Amorphous Solids9An Investigation of the Impact of Precipitation Temperature and Filter Cake Thickness on the Physical Stability of Amorphous Solids: A Case Study5The Optimization of Pair Distribution Functions for the Evaluation of the Degree of Disorder and Physical Stability in Amorphous Solids3Solvates and Polymorphs of Axitinib: Characterization and Phase Transformation3Study on Triflumezopyrim Solid Forms: Crystal Structure Analysis and Suspension Concentrate Application Insights1Influence of Neutralization Precipitation Conditions on the Physical Stability of Amorphous Solid Pharmaceuticals1The Effect of Meloxicam Nanocrystal Formation with the Addition of PVP K-60 and Decyl Glucoside as Stabilizers on Its Solubility0Effect of Solute Concentration and Filtration Rate on the Scale Production of a Physically Stable Amorphous Solid Form of Nilotinib0Discovery of a novel acetone hemisolvate of metacetamol via swift cooling crystallization1Study on the Formation Mechanism of Doramectin Solvate and the Desolvation Process1Crystal engineering for poorly water-soluble drugs: From design to applications14Mechanochemical Fabrication of UiO-66-Supported Nilotinib Polymorphs for Drug Delivery0Solvation‐Driven Modulation of Crystal Packing in Metacetamol: Insights From X‐Ray Diffraction, Hirshfeld, and Void Analyses0

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  1. Synthetic Strategies toward Higher Cocrystals of Some Resorcinols

    Crystal Growth & Design · 2022-11-22

    Sourav Roy, Ruchi Gaur, Mithun Paul, Madhu Rajkumar, Gautam Radhakrishna Desiraju

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  2. Polymorph Screening of the Antitumor Drug Ripretinib─Selective Preference of Dimer Synthons

    Crystal Growth & Design · 2023-03-24

    T. K. S. Fayaz, Parag Sinchan Roy, Animesh Ghosh, Shubham Som, Deepak Chopra, Palash Sanphui

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  3. Two new nilotinib polymorphs with solubility advantages prepared by the melt crystallization process

    Journal of Drug Delivery Science and Technology · 2023-04-24

    Xiangjun Shi, Yu Deng, Zijuan Wang, Xinyue Liu, Qifeng Chen, Junjie Peng, Xiaoyi Xing, Wei Ke Su

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  4. Optimization of precipitation conditions for producing physically stable amorphous solids using pair distribution function and reduced crystallization temperature

    Journal of Drug Delivery Science and Technology · 2023-12-14

    Zunhua Li, Jie Luo, Xuncai Chen, Bowen Zhang, Asad Nawaz, Wubliker Dessie

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  5. Polymorph transformation of solid drugs and inhibiting strategies

    CrystEngComm · 2024-01-01

    Yaoguang Feng, Hui Zhu Wang, Di Wu, Kui Chen, Na Wang, Ting Wang, Xin Huang, Lina Zhou, Hongxun Hao

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  6. Crystal Structure of Nilotinib Hydrochloride Monohydrate According to Powder X-Ray Diffraction Data

    Journal of Structural Chemistry · 2024-03-01

    Alexander S. Goloveshkin, E. S. Kulikova, Роман А. Новиков, Anna Vladimirovna Vologzhanina, Alexander Aleksandrovich Korlyukov

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  7. Investigation of the Influence of Anti-Solvent Precipitation Parameters on the Physical Stability of Amorphous Solids

    Molecules · 2024-03-13

    Zunhua Li, Zicheng Gong, Bowen Zhang, Asad Nawaz

    Read original paper ↗ ·

  8. An Investigation of the Impact of Precipitation Temperature and Filter Cake Thickness on the Physical Stability of Amorphous Solids: A Case Study

    Molecules · 2024-05-15

    Zunhua Li, Xu Liao, Zicheng Gong, Bowen Zhang, Asad Nawaz

    Read original paper ↗ ·

  9. The Optimization of Pair Distribution Functions for the Evaluation of the Degree of Disorder and Physical Stability in Amorphous Solids

    Molecules · 2024-05-18

    Zhihui Yuan, Zunhua Li, Jie Luo, Asad Nawaz, Bowen Zhang, Wubliker Dessie

    Read original paper ↗ ·

  10. Solvates and Polymorphs of Axitinib: Characterization and Phase Transformation

    Molecules · 2024-10-04

    Yinhu Pan, Tong Xiao, Yan Wang, Zhiying Pan, Shichao Du, Fumin Xue

    Read original paper ↗ ·

  11. Study on Triflumezopyrim Solid Forms: Crystal Structure Analysis and Suspension Concentrate Application Insights

    Crystal Growth & Design · 2024-11-08

    Mingxia Wang, Xiaoyan Li, Bin Zhu, Guo‐Bin Ren, Ming‐Hui Qi, Zhong Li, Xiaoyong Xu

    Read original paper ↗ ·

  12. Influence of Neutralization Precipitation Conditions on the Physical Stability of Amorphous Solid Pharmaceuticals

    Molecules · 2025-02-07

    Zhihui Yuan, Xu Liao, Bowen Zhang, Asad Nawaz, Zunhua Li

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  13. The Effect of Meloxicam Nanocrystal Formation with the Addition of PVP K-60 and Decyl Glucoside as Stabilizers on Its Solubility

    Jurnal Kimia Sains dan Aplikasi · 2025-05-15

    Titta Hartyana Sutarna, Tika Meilina, Nur Achsan Al-Hakim

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  14. Effect of Solute Concentration and Filtration Rate on the Scale Production of a Physically Stable Amorphous Solid Form of Nilotinib

    Pharmaceutics · 2025-07-31

    Zhihui Yuan, Bowen Zhang, Asad Nawaz, Zunhua Li

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  15. Discovery of a novel acetone hemisolvate of metacetamol via swift cooling crystallization

    CrystEngComm · 2025-11-26

    Architha Natarajan, K. Srinivasan

    Read original paper ↗ ·

  16. Study on the Formation Mechanism of Doramectin Solvate and the Desolvation Process

    Crystal Growth & Design · 2025-12-02

    Runxi Gui, Tong Li, Maolin Li, Yinxiao Du, Songgu Wu, Lina Zhou, Junbo Gong

    Read original paper ↗ ·

  17. Crystal engineering for poorly water-soluble drugs: From design to applications

    Acta Pharmaceutica Sinica B · 2025-12-06

    An Chen, Yayun Peng, Zhuangzhuang Chen, Yi Lu, Minshan Guo, Ting Cai

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  18. Mechanochemical Fabrication of UiO-66-Supported Nilotinib Polymorphs for Drug Delivery

    Journal of Pharmaceutical Innovation · 2026-04-28

    Junjie Peng, Yue Wang, Jianghao Yuan, Mingkang Xu, Da Wu, Bokai Kong, Z Zhang, Xiangjun Shi, Weike Su

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  19. Solvation‐Driven Modulation of Crystal Packing in Metacetamol: Insights From X‐Ray Diffraction, Hirshfeld, and Void Analyses

    Crystal Research and Technology · 2026-07-01

    Architha Natarajan, K. Srinivasan

    Read original paper ↗ ·
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