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RESEARCH PAPER · Reaction Chemistry & Engineering · 2021

Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients

Cloudius Ray Sagandira, Sinazo Nqeketo, Kanyisile Mhlana, Thembela Sonti, Sibongiseni Gaqa, Paul Watts

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Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredientsOriginalConstruction of an α-chiral pyrrolidine library with a rapid and scalable continuous flow protocol3Hybrid Lean Practices Integrated with IR 4.0 and Sustainability in Malaysia Food and Beverages Companies: Conceptual Framework and Hypothesis Development14Analytical Tools Integrated in Continuous-Flow Reactors: Which One for What?63Scaled up and telescoped synthesis of propofol under continuous-flow conditions19Will the next generation of chemical plants be in miniaturized flow reactors?38Bayesian optimization-driven parallel-screening of multiple parameters for the flow synthesis of biaryl compounds31Inline purification in continuous flow synthesis – opportunities and challenges28An integrated five-step continuous flow synthesis of 2-(1-cyclohexenyl)ethylamine: a key intermediate for morphinans1Chemical development: Synthetic studies and engineering including aspects of batch production and continuous processing0Solvent-free synthesis of chalcones using Mg(HSO 4 ) 29Systematic study of FFF materials for digitalizing chemical reactors with 3D printing: superior performance of carbon-filled polyamide9Process Intensification and Increased Safety for the On-Demand Continuous Flow Synthesis of Dithiothreitol, a Crucial Component in Polymerase Chain Reaction Testing Kits4Polyetheretherketone fiber-supported TBD as an efficient fibrous superbase catalyst for organic conversions in continuous-flow processing18Advanced In-Line Purification Technologies in Multistep Continuous Flow Pharmaceutical Synthesis27Engineering Innovations, Challenges, and Opportunities for Lignocellulosic Biorefineries: Leveraging Biobased Polymer Production36FAQT-2: A customer-oriented method for MCDM with statistical verification applied to industrial robot selection18Continuous flow Friedel–Crafts acetylation of phenols and electron-rich arenes and heteroarenes4Robotics and Aseptic Processing in View of Regulatory Requirements10Continuous Flow Oxidation of Alcohols Using TEMPO/NaOCl for the Selective and Scalable Synthesis of Aldehydes20Preparation of glycoside precursors in flow from food flavours containing a phenolic hydroxyl group1A cyanide-free synthesis of nitriles exploiting flow chemistry3Hybrid Modeling of an Active Pharmaceutical Ingredient Flow Synthesis in a Ring-Opening Reaction of an Epoxide with a Grignard Reagent12Continuous Flow Synthesis of Nitrosoarenes via Photochemical Rearrangement of Aryl Imines10Autonomous reaction self-optimization using in-line high-field NMR spectroscopy10Continuous flow synthesis and crystallization of modafinil: a novel approach for integrated manufacturing6Continuous flow synthesis of the antiviral drug tecovirimat and related sp 3 -rich scaffolds5Efficient construction of a β-naphthol library under continuous flow conditions2The role of PAT in the development of telescoped continuous flow processes21Telescoped Hybrid Batch–Flow Synthesis of 2-Butylbenzofuran1Continuous flow synthesis of C-acyloxy-substituted aziridines in microchannel reactor: Addition of carboxylic acids to 2-methylenaziridines3Advances in the Continuous Flow Synthesis of 3‐ and 4‐Membered Ring Systems9Top 20 influential AI-based technologies in chemistry50Lab-on-a-chip: Efficient Preparation of Bioactive Compounds Using On-chip Flow Synthesis0Sequential‐Flow Synthesis of Donepezil: A Green and Sustainable Strategy Featuring Heterogeneous Catalysis and Hydrogenation9Microwave-assisted continuous flow synthesis of propofol2A cascade Markovnikov addition/Lewis acid-catalyzed rearrangement of methyleneaziridines and carboxylic acids: continuous-flow synthesis of α-amidoketones1Advances in the Synthesis and Optimization of Pharmaceutical APIs: Trends and Techniques1Chemistry as a Catalyst for Transforming the Health and Wealth of South Africa1Chemistry as a Catalyst for Transforming the Health and Wealth of South Africa3Reshaping Chemical Manufacturing Towards Green Process Intensification: Recent Findings and Perspectives21Continuous Flow Technology Enabling Photochemistry35Efficient synthesis of m-terphenyl compounds in continuous flow utilizing organomagnesium2Generation and Use of Reactive Intermediates Exploiting Flow Technology1Hybrid Enabling Technologies for Organic Synthesis0Intelligent Chemical Synthesis in an Undergraduate Teaching Laboratory: Continuous Flow Synthesis of S N Ar Reaction with Automated Robot-Assisted Condition Screening5Agile local manufacturing of active pharmaceutical ingredients in Africa could improve health security and economic growth1A dynamic radial-based self-adaptive framework for modelling the Consigma-25 continuous tablet production line0Utilizing metal-organic frameworks and covalent-organic frameworks for enhanced cathode design and separator functionality in metal-sulfur batteries2Continuous flow platform for the selective and rapid monoalkylation of amines0Efficient Oxidation of Alcohols Using a Bioinspired Tetradentate Aminopyridine Manganese Catalyst with H 2 O 2 : Batch and Continuous Flow Studies0Kinetics-Guided Multistep Continuous Synthesis of Quinizarin Derivatives via Evaporation-Assisted CSTR–PFR Cascade0Advances in solid handling for continuous flow synthesis of specialty chemicals and pharmaceuticals8Online IR spectroscopic quantification and reaction process analysis in continuous flow system0Continuous hydrogenation for the manufacture of albuterol sulfate1Process-Intensified Continuous Flow Synthesis of Propofol2Two-stage optimization of continuous flow synthesis of L-carnitine combining Bayesian optimization, inline analysis, and kinetic modeling0

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  1. Construction of an α-chiral pyrrolidine library with a rapid and scalable continuous flow protocol

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  2. Hybrid Lean Practices Integrated with IR 4.0 and Sustainability in Malaysia Food and Beverages Companies: Conceptual Framework and Hypothesis Development

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  3. Analytical Tools Integrated in Continuous-Flow Reactors: Which One for What?

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  4. Scaled up and telescoped synthesis of propofol under continuous-flow conditions

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  5. Will the next generation of chemical plants be in miniaturized flow reactors?

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  6. Bayesian optimization-driven parallel-screening of multiple parameters for the flow synthesis of biaryl compounds

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    Masaru Kondo, H. D. P. Wathsala, Mohamed S. H. Salem, Kazunori Ishikawa, Satoshi Hara, Takayuki Takaai, Takashi Washio, Hiroaki Sasai, Shinobu Takizawa

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  7. Inline purification in continuous flow synthesis – opportunities and challenges

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  8. An integrated five-step continuous flow synthesis of 2-(1-cyclohexenyl)ethylamine: a key intermediate for morphinans

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  9. Chemical development: Synthetic studies and engineering including aspects of batch production and continuous processing

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  10. Solvent-free synthesis of chalcones using Mg(HSO 4 ) 2

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  11. Systematic study of FFF materials for digitalizing chemical reactors with 3D printing: superior performance of carbon-filled polyamide

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    Victoria A. Korabelnikova, Evgeniy G. Gordeev, Valentine P. Ananikov

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  12. Process Intensification and Increased Safety for the On-Demand Continuous Flow Synthesis of Dithiothreitol, a Crucial Component in Polymerase Chain Reaction Testing Kits

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    Maryne A. J. Dubois, Virginie Carreras, Matt R. Adams, Vanessa Kairouz, Jean-François Vincent-Rocan, John G. Riley, André B. Charette

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  13. Polyetheretherketone fiber-supported TBD as an efficient fibrous superbase catalyst for organic conversions in continuous-flow processing

    Journal of Catalysis · 2023-01-12

    Xian‐Lei Shi, Yue Lv, Tian Zhang, Qianqian Hu, Keren Shi, Wenqin Zhang, Zhenhua Li

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  14. Advanced In-Line Purification Technologies in Multistep Continuous Flow Pharmaceutical Synthesis

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  15. Engineering Innovations, Challenges, and Opportunities for Lignocellulosic Biorefineries: Leveraging Biobased Polymer Production

    Annual Review of Chemical and Biomolecular Engineering · 2023-04-11

    Alison J. Shapiro, Robert M. O’Dea, Sonia C. Li, Jamael Ajah, Garrett F. Bass, Thomas H. III Epps

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  16. FAQT-2: A customer-oriented method for MCDM with statistical verification applied to industrial robot selection

    Expert Systems with Applications · 2023-04-12

    Hassan Soltan, Khaled Janada, Mohamed Omar

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  17. Continuous flow Friedel–Crafts acetylation of phenols and electron-rich arenes and heteroarenes

    Journal of Flow Chemistry · 2023-05-09

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  18. Robotics and Aseptic Processing in View of Regulatory Requirements

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    Andrea Tanzini, Marco Ruggeri, Eleonora Bianchi, Caterina Valentino, Barbara Vigani, Franca Ferrari, Silvia Rossi, Hermes Giberti, Giuseppina Sandri

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  19. Continuous Flow Oxidation of Alcohols Using TEMPO/NaOCl for the Selective and Scalable Synthesis of Aldehydes

    Organic Process Research & Development · 2023-09-07

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  20. Preparation of glycoside precursors in flow from food flavours containing a phenolic hydroxyl group

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  21. A cyanide-free synthesis of nitriles exploiting flow chemistry

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  22. Hybrid Modeling of an Active Pharmaceutical Ingredient Flow Synthesis in a Ring-Opening Reaction of an Epoxide with a Grignard Reagent

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  23. Continuous Flow Synthesis of Nitrosoarenes via Photochemical Rearrangement of Aryl Imines

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  24. Autonomous reaction self-optimization using in-line high-field NMR spectroscopy

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  25. Continuous flow synthesis and crystallization of modafinil: a novel approach for integrated manufacturing

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  26. Continuous flow synthesis of the antiviral drug tecovirimat and related sp 3 -rich scaffolds

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  27. Efficient construction of a β-naphthol library under continuous flow conditions

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  28. The role of PAT in the development of telescoped continuous flow processes

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  33. Lab-on-a-chip: Efficient Preparation of Bioactive Compounds Using On-chip Flow Synthesis

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  34. Sequential‐Flow Synthesis of Donepezil: A Green and Sustainable Strategy Featuring Heterogeneous Catalysis and Hydrogenation

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  35. Microwave-assisted continuous flow synthesis of propofol

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  36. A cascade Markovnikov addition/Lewis acid-catalyzed rearrangement of methyleneaziridines and carboxylic acids: continuous-flow synthesis of α-amidoketones

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  37. Advances in the Synthesis and Optimization of Pharmaceutical APIs: Trends and Techniques

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  38. Chemistry as a Catalyst for Transforming the Health and Wealth of South Africa

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  42. Efficient synthesis of m-terphenyl compounds in continuous flow utilizing organomagnesium

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  46. Agile local manufacturing of active pharmaceutical ingredients in Africa could improve health security and economic growth

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  47. A dynamic radial-based self-adaptive framework for modelling the Consigma-25 continuous tablet production line

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  49. Continuous flow platform for the selective and rapid monoalkylation of amines

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  50. Efficient Oxidation of Alcohols Using a Bioinspired Tetradentate Aminopyridine Manganese Catalyst with H 2 O 2 : Batch and Continuous Flow Studies

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