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RESEARCH PAPER · Materials · 2021

Artificial Intelligence Aided Design of Tissue Engineering Scaffolds Employing Virtual Tomography and 3D Convolutional Neural Networks

María Dolores Bermejillo Barrera, Francisco Franco Martínez, Andrés Díaz Lantada

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Artificial Intelligence Aided Design of Tissue Engineering Scaffolds Employing Virtual Tomography and 3D Convolutional Neural NetworksOriginalEnhanced Cellular Materials through Multiscale, Variable-Section Inner Designs: Mechanical Attributes and Neural Network Modeling20Surface and Structural Studies of Age-Related Changes in Dental Enamel: An Animal Model6An Overview of Artificial Intelligence in Product Design for Smart Manufacturing15State-of-the-art techniques for imaging the vascular microenvironment in craniofacial bone tissue engineering applications15Data Mining Approach to Characterization of Bioactive Inorganic Scaffold Properties Using Synthetic Images0Effects of surface patterning and topography on the cellular functions of tissue engineered scaffolds with special reference to 3D bioprinting42AI in angiogenesis: moving towards designer vasculature1Artificial intelligence in multiscale scaffolds for cancer organoids testbed1Artificial Intelligence in tissue and organ regeneration: An introduction0Impact of a staggered scaffold structure on the mechanical properties and cell response in bone tissue engineering5ML and AI approaches for design of tissue scaffolds7Machine learning and experiments: A synergy for the development of functional materials19Identification and ranking biomaterials for bone scaffolds using machine learning and PROMETHEE32Biomechanical Behaviors and Degradation Properties of Multilayered Polymer Scaffolds: The Phase Space Method for Bile Duct Design and Bioengineering34Deep Learning in Mechanical Metamaterials: From Prediction and Generation to Inverse Design372Advanced Fabrication of Mechanical Metamaterials Based on Micro/Nanoscale Technology25Additive Manufacturing Approaches to Design Pore Structures for Development of Bioactive Scaffolds for Orthopedic Applications: A Critical Review5Intelligent Materials and Nanomaterials Improving Physical Properties and Control Oriented on Electronic Implementations24Application of Artificial Intelligence in Regenerative Medicine4Development of Bioactive Scaffolds for Orthopedic Applications by Designing Additively Manufactured Titanium Porous Structures: A Critical Review37Bone Regeneration Induced by Patient-Adapted Mg Alloy-Based Scaffolds for Bone Defects: Present and Future Perspectives27Application of Artificial Intelligence at All Stages of Bone Tissue Engineering61Digital Applications in Dental and Craniofacial Tissue Engineering1Harnessing the power of machine learning into tissue engineering: current progress and future prospects47Recent Trends and Challenges of Biomaterials for Tissue Regeneration0Enhancing quality control in bioprinting through machine learning36Machine Learning approaches for the design of biomechanically compatible bone tissue engineering scaffolds62Impact of Artificial Intelligence and Machine Learning on Urological Practice2Application of Artificial Intelligence in Tissue Engineering70Machine Learning in Biomaterials, Biomechanics/Mechanobiology, and Biofabrication: State of the Art and Perspective60Spectroscopic Characterization of Biomaterials for Tissue Engineering Applications3AI-Based Metamaterial Design95Revolutionizing Healthcare and Drug Discovery: The Impact of Artificial Intelligence on Pharmaceutical Development9Artificial Intelligence Software Adoption in Manufacturing Companies24Toward Fully Automated Personalized Orthopedic Treatments: Innovations and Interdisciplinary Gaps29Fostering creativity in engineering design through constructive dialogues with generative artificial intelligence10Blueprints of Architected Materials: A Guide to Metamaterial Design for Tissue Engineering43A review of computational optimization of bone scaffold architecture: methods, challenges, and perspectives35AI for biofabrication25AI-Based solutions for current challenges in regenerative medicine33Implications of Biomaterials and Adipose-Derived Stem Cells in the Management of Calvarial Bone Defects1A Review of 3D Printing by Robocasting and Stereolithography for Cartilage and Ocular Tissue Regeneration12Review on machine learning application in tissue engineering: What has been done so far? Application areas, challenges, and perspectives41Three-point bending behaviors of sandwich beams with data-driven 3D auxetic lattice core based on deep learning29A review of advances in 3D and 4D bioprinting: toward mass individualization paradigm18Applications of artificial intelligence in regenerative dentistry: promoting stem cell therapy and the scaffold development19Application of Artificial Intelligence in Orthopedic Tissue Engineering: Current Status and Future Prospects of Research0Artificial Intelligence in Predicting Hard Tissue Regeneration: Current Situation and Upcoming Perspectives0Bioinspired and Biomimetic Materials/Architecture in Cardiovascular Regeneration0Dry-Lab Computational Approaches for Simulating Bioinspired Materials/Structures for Regenerative Medicine1Integrating Modern Technologies into Traditional Anterior Cruciate Ligament Tissue Engineering6Advancements in 3D printing technologies for personalized treatment of osteonecrosis of the femoral head15Role of 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on natural language processing and reinforcement learning6Structural influences on bone tissue engineering: A review and perspective30Exploring the synergistic interactions between artificial intelligence and biomimicry for sustainable solutions3Artificial intelligence for design strategies of tissue engineering materials13Development of an ML-based design tool for predicting optimal lattice configurations for patient-specific endoprostheses2Artificial intelligence-enabled Bioprinting 5.03Mechanochemistry as a Gamechanger0Regenerative Engineering: Evolution and Its Modern Significance4Effect of Surgical Tightening Torque on the Pull-Out Strength of Screws in Vertebral Body Tethering1Synthetic SEM-EDX Dataset and U-Net-Based Segmentation Framework for Microstructural Defect Detection in Biomaterial Coatings0Nanofluidics, 3D nano-printing, and organoids for biomedical technology0Integration of Machine Learning and Automated Synthesis for Accelerated Drug and Material Research0Bioengineered Teeth and Regenerative Strategies: Advances in Tissue Engineering and Stem Cell Applications4Design optimization of metastructures integrating machine learning with energy-based homogenization1Bioprinting Organs—Science or Fiction?—A Review From Students to Students3AI-driven closed-loop extrusion-based bioprinting system: from dynamic regulation to medical translation2Artificial intelligence in biopolymer design and engineering2Artificial intelligence in prosthodontic biomaterials1Intelligent tools for biomaterials design0The Application of Artificial Intelligence (AI) in Regenerative Medicine: Current Insights and Challenges11Regenerative Medicine in China: Current Regulatory Challenges and Global Advancements1Indirect 3D printing in tissue engineering: expanding materials used for improved scaffold functionality4Artificial intelligence in predictive, personalized, and regenerative endodontics: A narrative review of emerging paradigms1An end-to-end generative pipeline for designing Triply-Periodic Minimal Surface scaffolds0Bioinformatics and AI in dental biomaterials: Applications in drug delivery for tissue engineering0Deep Learning in Cardiovascular Tissue Engineering: A Review on Current Advances and Future Perspectives1Future perspectives: data-driven design and artificial intelligence for additive-manufactured architected metamaterials0Product and Process Design for Industrial Manufacturing of Cell and Tissue Engineered Products0Smart Biosensing Platforms for Osteochondral Tissue Engineering2Smart Nanotechnology for Tissue Engineering0Use of Artificial Intelligence in Biofabrication0Biomimetic electrospun scaffolds for engineered heart tissue: from design parameters to drug testing platforms4Design, properties and applications of additively-manufactured functional hierarchical structure5Advances in the Application of Additive Manufacturing in Respiratory Inhalation Therapy0Mimicking the Ocean: Critical Challenges in Scaffold Design and Tissue Texturization for Cell‐Cultured Seafood4Machine learning in tissue engineering: a comprehensive review of applications, challenges, and prospects2Dual-CNN-based AI framework for patient-specific design of short femoral stems0A review of plasmonic wave generation: Materials, AI-based design approaches, and applications1Skin grafting and regeneration: Bridging biological barriers towards functional regeneration0Reproducibility and Validation Challenges in AI-Driven Scaffold Design for Bone Regeneration0Artificial Intelligence and Digital Workflow in Craniofacial Bone Tissue Engineering: From Cone-Beam Computed Tomography (CBCT) to Personalized Bioceramic Implants0Polymer-Based Biomaterials in Periodontal and Peri-Implant Soft Tissue Augmentation: Biological Rationale, Clinical Applications, and Future Perspectives0Regenerative nanotechnology: Highlighting human tissue engineering0Sustainable hemocompatibility prediction of electrospun nanomaterials using SEM-driven CNN ensemble learning aligned with ISO 109930Substrate stiffness regulates cell fate and its applications in the repair of motor system: From two dimensions to three dimensions0Artificial intelligence-driven design of smart biomaterials for next-generation tissue engineering and personalized regeneration0

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