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RESEARCH PAPER · Advanced Healthcare Materials · 2017

Supercritical Fluid Technology: An Emphasis on Drug Delivery and Related Biomedical Applications

Ranjith Kumar Kankala, Yu Shrike Zhang, Shi‐Bin Wang, Chia‐Hung Lee, Ai‐Zheng Chen

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Supercritical Fluid Technology: An Emphasis on Drug Delivery and Related Biomedical ApplicationsOriginalOvercoming Multidrug Resistance through the Synergistic Effects of Hierarchical pH-Sensitive, ROS-Generating Nanoreactors166In vivo assessment of a novel biodegradable ureteral stent59Continuous nanonization of lonidamine by modified-rapid expansion of supercritical solution process70A rapid hemostatic sponge based on large, mesoporous silica nanoparticles and N -alkylated chitosan86Beta-cyclodextrin modified mesoporous bioactive glass nanoparticles/silk fibroin hybrid nanofibers as an implantable estradiol delivery system for the potential treatment of osteoporosis36Electrospun porous PLLA and poly(LLA- co -CL) fibers by phase separation21Self-Assembled Nanogels: From Particles to Scaffolds and Membranes23Enhancing the dissolution of phenylbutazone using Syloid® based mesoporous silicas for oral equine applications45Cardiac Tissue Engineering on the Nanoscale103pH-sensitive nanocarriers for Ganoderma applanatum polysaccharide release via host–guest interactions17Nanomedicine: The next-generation therapeutics0Cyclosporine A/porous quaternized chitosan microspheres as a novel pulmonary drug delivery system26Leveraging Engineering of Indocyanine Green-Encapsulated Polymeric Nanocomposites for Biomedical Applications72Supercritical carbon dioxide-based technologies for the production of drug nanoparticles/nanocrystals – A comprehensive review262In vivo Acute Cytotoxicity Study of Poly(2-amino ethyl methacrylate-co-methylene bis-acrylamide) Magnetic Composite Synthesized in Supercritical CO27HETEROGEN CATALYSIS IN SUSTAINABLE GREEN SOLVENT: ALKENES HYDROGENATION WITH NEW SILICA IMMOBILIZED PALLADIUM COMPLEX CONTAINING S,O-CHELATING LIGAND2Solution-enhanced dispersion by supercritical fluids: an ecofriendly nanonization approach for processing biomaterials and pharmaceutical compounds72Dosing challenges in respiratory therapies29Nanostructured Lipid Carriers as Promising Delivery Systems for Plant Extracts: The Case of Silymarin553D-Printing of Microfibrous Porous Scaffolds Based on Hybrid Approaches for Bone Tissue Engineering73Overcoming multidrug resistance through inhalable siRNA nanoparticles-decorated porous microparticles based on supercritical fluid technology56Chitosan-Based Composite Materials for Prospective Hemostatic Applications276Mesoporous Silica Nanoparticles: A Comprehensive Review on Synthesis and Recent Advances942Effect of Icariin on Engineered 3D-Printed Porous Scaffolds for Cartilage Repair33Synthesis and Characterization of Dual Stimuli-Sensitive Biodegradable Polyurethane Soft Hydrogels for 3D Cell-Laden Bioprinting100Solution enhanced dispersion by supercritical fluids (SEDS): An approach in particle engineering to modify aqueous solubility of andrographolide from Andrographis paniculata extract17The prospect of layered double hydroxide as bone implants: A study of mechanical properties, cytocompatibility and antibacterial activity63Supercritical Fluid-Assisted Fabrication of Indocyanine Green-Encapsulated Silk Fibroin Nanoparticles for Dual-Triggered Cancer Therapy61Characterization and Preliminary Biological Evaluation of 3D-Printed Porous Scaffolds for Engineering Bone Tissues39Supercritical Fluid-Assisted Decoration of Nanoparticles on Porous Microcontainers for Codelivery of Therapeutics and Inhalation Therapy of Diabetes40Supercritical Fluid‐Assisted Porous Microspheres for Efficient Delivery of Insulin and Inhalation Therapy of Diabetes42“Nano in micro” architecture composite membranes for controlled drug delivery19Recent Progress of Supercritical Carbon Dioxide in Producing Natural Nanomaterials6VE-Albumin Core-Shell Nanoparticles for Paclitaxel Delivery to Treat MDR Breast Cancer30Materials Science and Design Principles of Growth Factor Delivery Systems in Tissue Engineering and Regenerative Medicine178Modeling phase behavior of Poly(ɛ-caprolactone) solutions at high pressure7Scaffold with Orientated Microtubule Structure Containing Polylysine-Heparin Sodium Nanoparticles for the Controlled Release of TGF-β1 in Cartilage Tissue Engineering21Formation of porous biodegradable scaffolds based on poly(propylene carbonate) using gas foaming technology98Nano-hydroxyapatite-alginate-gelatin microcapsule as a potential osteogenic building block for modular bone tissue engineering83Polydopamine-modified poly( l -lactic acid) nanofiber scaffolds immobilized with an osteogenic growth peptide for bone tissue regeneration53Microencapsulation and Nanoencapsulation Using Supercritical Fluid (SCF) Techniques151Applying Supercritical Fluid Technology to Prepare Ibuprofen Solid Dispersions with Improved Oral Bioavailability23Microengineered Organ-on-a-chip Platforms towards Personalized Medicine34Generation of sustained release chitosan nanoparticles for delivery of ketorolac tromethamine: a tubular microreactor approach24Model Building on Selectivity of Gas Antisolvent Fractionation Method Using the Solubility Parameter4Supercritical fluid-assisted controllable fabrication of open and highly interconnected porous scaffolds for bone tissue engineering8Effective encapsulation of curcumin in nanoparticles enabled by hydrogen bonding using flash nanocomplexation36Meeting the unmet: from traditional to cutting-edge techniques for poly lactide and poly lactide-co-glycolide microparticle manufacturing63Solubility measurement and RESOLV-assisted nanonization of gambogic acid in supercritical carbon dioxide for cancer therapy53Highly Porous Microcarriers for Minimally Invasive In Situ Skeletal Muscle Cell Delivery147Smart Nanovesicles for Drug Targeting and Delivery4A new era for sterilization based on supercritical CO 2 technology122Enhancing osseointegration of titanium implants through large-grit sandblasting combined with micro-arc oxidation surface modification51Antitumor effect of hyaluronic-acid-modified chitosan nanoparticles loaded with siRNA for targeted therapy for non-small cell lung cancer121Novel purine thioglycoside analogs: synthesis, nanoformulation and biological evaluation in in vitro human liver and breast cancer models20Supercritical Solvent Impregnation of Different Drugs in Mesoporous Nanostructured ZnO19Recent Developments in Carriers and Non-Aqueous Solvents for Enzyme Immobilization48Carbon‐Doped Metal Oxide Nanoparticles Prepared from Metal Nitrates in Supercritical CO2‐Enabled Polymer Nanoreactors10Improved self-assembled micelles based on supercritical fluid technology as a novel oral delivery system for enhancing germacrone oral bioavailability17Metal Species–Encapsulated Mesoporous Silica Nanoparticles: Current Advancements and Latest Breakthroughs184Polyacrylate/polyacrylate-PEG biomaterials obtained by high internal phase emulsions (HIPEs) with tailorable drug release and effective mechanical and biological properties32Preparation of irbesartan composite microparticles by supercritical aerosol solvent extraction system for dissolution enhancement21Measurement and Correlation of Paeonol Solubility in Supercritical Carbon Dioxide10Supercritical fluid methods: An alternative to conventional methods to prepare liposomes157Recent Advances in Polymeric Nanocomposites of Metal-Organic Frameworks (MOFs)42Dispersed graphene materials of biomedical interest and their toxicological consequences47Using Supercritical Fluid Technology as a Green Alternative During the Preparation of Drug Delivery Systems169Amorphous drug stabilization using mesoporous materials6Applications of Supercritical Carbon Dioxide in the Rubber Industry4Body temperature polymerization and in situ drug encapsulation in supercritical carbon dioxide5Micronized curcumin fabricated by supercritical CO 2 to improve antibacterial activity against Pseudomonas aeruginosa21Polymeric vehicles for nucleic acid delivery224Progress in lead-free piezoelectric nanofiller materials and related composite nanogenerator devices123Supercritical Fluid Techniques to Fabricate Efficient Nanoencapsulated Food-Grade Materials3Application of Box–Behnken Design to Investigate the Effect of Process Parameters on the Microparticle Production of Ethenzamide through the Rapid Expansion of the Supercritical Solutions Process12Micronization of Three Active Pharmaceutical Ingredients Using the Rapid Expansion of Supercritical Solution Technology13Zein/soluble soybean polysaccharide composite nanoparticles for encapsulation and oral delivery of lutein202Gambogic acid augments black phosphorus quantum dots (BPQDs)-based synergistic chemo-photothermal therapy through downregulating heat shock protein expression121Experimental Determination and Association Model for the Solubility of Laminarin in Supercritical Carbon Dioxide8Fabrication of Supercritical Antisolvent (SAS) Process-Assisted Fisetin-Encapsulated Poly (Vinyl Pyrrolidone) (PVP) Nanocomposites for Improved Anticancer Therapy43Sericin and fibroin nanoparticles—natural product for cancer therapy: a comprehensive review60Improving Solubility and Bioavailability of Breviscapine with Mesoporous Silica Nanoparticles Prepared Using Ultrasound-Assisted Solution-Enhanced Dispersion by Supercritical Fluids Method25Supercritical antisolvent process-assisted fabrication of chrysin-polyvinylpyrrolidone sub-microparticles for improved anticancer efficiency22Solid Solubilities of Sulfonamides and Use of Rapid Expansion of Supercritical Solutions for Microparticle Production8A superstable homogeneous lipiodol-ICG formulation for locoregional hepatocellular carcinoma treatment89Sub-micronization of disulfiram and disulfiram-copper complexes by Rapid expansion of supercritical solution toward augmented anticancer effect23Supercritical Fluid Technology and its Pharmaceutical Applications: A Revisit with Two Decades of Progress29Engineered exosome for NIR-triggered drug delivery and superior synergistic chemo-phototherapy in a glioma model30Chitosan Nanoparticles as a Novel Drug Delivery System: A Review Article90Applications of Nanopharmaceuticals in Delivery and Targeting4Development and validation of a two-dimensional population balance model for a supercritical CO2 antisolvent batch crystallization process13Polymeric nanocarriers in targeted drug delivery systems: A review86Synthesis of Micro- and Nanoparticles in Sub- and Supercritical Water: From the Laboratory to Larger Scales26Respiratory Tract: Structure and Attractions for Drug Delivery Using Dry Powder Inhalers41Lidocaine-Loaded Solid Lipid Microparticles (SLMPs) Produced from Gas-Saturated Solutions for Wound Applications27Impregnation of Poly(methyl methacrylate) with Carbamazepine in Supercritical Carbon Dioxide: Molecular Dynamics Simulation20Supercritical fluids in chemistry101Silk-fibroin Nano-drug Delivery Systems1Bridging the preoperative gap of precision hepatectomy: Superstable homogeneous iodinated formulation technology2A supercritical fluid technology for liposome production and comparison with the film hydration method67Comparison of physical electrical conductivity and acupuncture de-qi sensation between stainless steel needling and supercritical fluid-treated needling14Highly Porous Fluorescent Materials Based on Polymer Matrices Impregnated with Eu(dbm)3 Molecules in a Supercritical Carbon Dioxide Medium3Micronization of Levofloxacin Using the RESS Method7Cellularized polymeric microarchitectures for drug screening6The Role of Hyaluronic Acid in Tissue Engineering1The Use of Supercritical Fluid Technologies for Nanoparticle Production2Liquid CO2 Formulated Mesoporous Silica Nanoparticles for pH-Responsive Oral Delivery of Meropenem36Experimental and thermodynamic modeling decitabine anti cancer drug solubility in supercritical carbon dioxide47Solubility of Amlodipine Besylate (Calcium Channel Blocker Drug) in Supercritical Carbon Dioxide: Measurement and Correlations73Low-temperature extrusion-based 3D printing of icariin-laden scaffolds for osteogenesis enrichment14PLGA encapsulated γ-cyclodextrin-meropenem inclusion complex formulation for oral delivery23Sterilization methods of liposomes: Drawbacks of conventional methods and perspectives73Aerogels in drug delivery: From design to application305Piroxicam Loading onto Mesoporous Silicas by Supercritical CO2 Impregnation12A Pathway From Porous Particle Technology Toward Tailoring Aerogels for Pulmonary Drug Administration41Preparation of liposomes composed of supercritical carbon dioxide-philic phospholipids using the rapid expansion of supercritical solution process10The solubility of Sulfabenzamide (an antibacterial drug) in supercritical carbon dioxide: Evaluation of a new thermodynamic model50A Recent Update: Solid Lipid Nanoparticles for Effective Drug Delivery100Synergistic foam stabilization and transport improvement in simulated fractures with polyelectrolyte complex nanoparticles: Microscale observation using laser etched glass micromodels7Supercritical Carbon Dioxide as a Green Alternative to Achieve Drug Complexation with Cyclodextrins35Supercritical fluid (SCF)-assisted fabrication of carrier-free drugs: An eco-friendly welcome to active pharmaceutical ingredients (APIs)85Biopesticide Encapsulation Using Supercritical CO2: A Comprehensive Review and Potential Applications35Development and Validation of Retention Models in Supercritical Fluid Chromatography for Impregnation Process Design03D bioprinting of conductive hydrogel for enhanced myogenic differentiation57A Critical Review on the Microencapsulation of Bioactive Compounds and Their Application93Ultra-fast single-crystal polymerization of large-sized covalent organic frameworks133Role of supercritical carbon dioxide (scCO2) in fabrication of inorganic-based materials: a green and unique route42A Pure NanoICG-Based Homogeneous Lipiodol Formulation: Toward Precise Surgical Navigation of Hepatocellular Carcinoma After Long-Term Transcatheter Arterial Embolization0Solute Diffusion into Polymer Swollen by Supercritical CO2 by High-Pressure Electron Paramagnetic Resonance Spectroscopy and Chromatography9A critical review on the particle generation and other applications of rapid expansion of supercritical solution43Particle size design of acetaminophen using supercritical carbon dioxide to improve drug delivery: Experimental and modeling32Polylactide, Processed by a Foaming Method Using Compressed Freon R134a, for Tissue Engineering2Application of supercritical fluid technology for solid dispersion to enhance solubility and bioavailability of poorly water-soluble drugs63Solid Dosage Forms of Biopharmaceuticals in Drug Delivery Systems Using Sustainable Strategies14Microencapsulation Technology a Holistic Approach in the Field of Pharmaceutical Sciences a Review0A pure nanoICG-based homogeneous lipiodol formulation: toward precise surgical navigation of primary liver cancer after long-term transcatheter arterial embolization51Stabilization of lipid vesicles: Upcoming strategic insights for product development6A super-stable homogeneous Lipiodol-hydrophilic chemodrug formulation for treatment of hepatocellular carcinoma58Combination drug delivery approaches for tuberculosis1Development of natural bioactive delivery systems through pressurized fluids-modern techniques1Nanoencapsulation of novel pyrazolone-based compounds to enhance solubility and biological activity.0Nanovesicles for targeting autoimmune diseases0Preparation of aripiprazole-poly(methyl vinyl ether-co-maleic anhydride) nanocomposites via supercritical antisolvent process for improved antidepression therapy9The Role of Hyaluronic Acid in Tissue Engineering3Overview of nanoparticulate strategies for solubility enhancement of poorly soluble drugs220Journey to the Market: The Evolution of Biodegradable Drug Delivery Systems29Liposomal-Based Formulations: A Path from Basic Research to Temozolomide Delivery Inside Glioblastoma Tissue42Bioaccessibility of Antioxidants in Blackcurrant Juice after Treatment Using Supercritical Carbon Dioxide26Bioinks Enriched with ECM Components Obtained by Supercritical Extraction12Computational prediction of drug solubility in supercritical carbon dioxide: Thermodynamic and artificial intelligence modeling48

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  1. Overcoming Multidrug Resistance through the Synergistic Effects of Hierarchical pH-Sensitive, ROS-Generating Nanoreactors

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  2. In vivo assessment of a novel biodegradable ureteral stent

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  3. Continuous nanonization of lonidamine by modified-rapid expansion of supercritical solution process

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  4. A rapid hemostatic sponge based on large, mesoporous silica nanoparticles and N -alkylated chitosan

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  5. Beta-cyclodextrin modified mesoporous bioactive glass nanoparticles/silk fibroin hybrid nanofibers as an implantable estradiol delivery system for the potential treatment of osteoporosis

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  6. Electrospun porous PLLA and poly(LLA- co -CL) fibers by phase separation

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  7. Self-Assembled Nanogels: From Particles to Scaffolds and Membranes

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  8. Enhancing the dissolution of phenylbutazone using Syloid® based mesoporous silicas for oral equine applications

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  10. pH-sensitive nanocarriers for Ganoderma applanatum polysaccharide release via host–guest interactions

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  11. Nanomedicine: The next-generation therapeutics

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  12. Cyclosporine A/porous quaternized chitosan microspheres as a novel pulmonary drug delivery system

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  13. Leveraging Engineering of Indocyanine Green-Encapsulated Polymeric Nanocomposites for Biomedical Applications

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  14. Supercritical carbon dioxide-based technologies for the production of drug nanoparticles/nanocrystals – A comprehensive review

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  15. In vivo Acute Cytotoxicity Study of Poly(2-amino ethyl methacrylate-co-methylene bis-acrylamide) Magnetic Composite Synthesized in Supercritical CO2

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  16. HETEROGEN CATALYSIS IN SUSTAINABLE GREEN SOLVENT: ALKENES HYDROGENATION WITH NEW SILICA IMMOBILIZED PALLADIUM COMPLEX CONTAINING S,O-CHELATING LIGAND

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  17. Solution-enhanced dispersion by supercritical fluids: an ecofriendly nanonization approach for processing biomaterials and pharmaceutical compounds

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  18. Dosing challenges in respiratory therapies

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  19. Nanostructured Lipid Carriers as Promising Delivery Systems for Plant Extracts: The Case of Silymarin

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  20. 3D-Printing of Microfibrous Porous Scaffolds Based on Hybrid Approaches for Bone Tissue Engineering

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  21. Overcoming multidrug resistance through inhalable siRNA nanoparticles-decorated porous microparticles based on supercritical fluid technology

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  24. Effect of Icariin on Engineered 3D-Printed Porous Scaffolds for Cartilage Repair

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  25. Synthesis and Characterization of Dual Stimuli-Sensitive Biodegradable Polyurethane Soft Hydrogels for 3D Cell-Laden Bioprinting

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  29. Characterization and Preliminary Biological Evaluation of 3D-Printed Porous Scaffolds for Engineering Bone Tissues

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  30. Supercritical Fluid-Assisted Decoration of Nanoparticles on Porous Microcontainers for Codelivery of Therapeutics and Inhalation Therapy of Diabetes

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  31. Supercritical Fluid‐Assisted Porous Microspheres for Efficient Delivery of Insulin and Inhalation Therapy of Diabetes

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  32. “Nano in micro” architecture composite membranes for controlled drug delivery

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  33. Recent Progress of Supercritical Carbon Dioxide in Producing Natural Nanomaterials

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  34. VE-Albumin Core-Shell Nanoparticles for Paclitaxel Delivery to Treat MDR Breast Cancer

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  35. Materials Science and Design Principles of Growth Factor Delivery Systems in Tissue Engineering and Regenerative Medicine

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  36. Modeling phase behavior of Poly(ɛ-caprolactone) solutions at high pressure

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  37. Scaffold with Orientated Microtubule Structure Containing Polylysine-Heparin Sodium Nanoparticles for the Controlled Release of TGF-β1 in Cartilage Tissue Engineering

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  38. Formation of porous biodegradable scaffolds based on poly(propylene carbonate) using gas foaming technology

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  39. Nano-hydroxyapatite-alginate-gelatin microcapsule as a potential osteogenic building block for modular bone tissue engineering

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  40. Polydopamine-modified poly( l -lactic acid) nanofiber scaffolds immobilized with an osteogenic growth peptide for bone tissue regeneration

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  41. Microencapsulation and Nanoencapsulation Using Supercritical Fluid (SCF) Techniques

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  42. Applying Supercritical Fluid Technology to Prepare Ibuprofen Solid Dispersions with Improved Oral Bioavailability

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  43. Microengineered Organ-on-a-chip Platforms towards Personalized Medicine

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  44. Generation of sustained release chitosan nanoparticles for delivery of ketorolac tromethamine: a tubular microreactor approach

    International Journal of Polymeric Materials · 2019-03-15

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  45. Model Building on Selectivity of Gas Antisolvent Fractionation Method Using the Solubility Parameter

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  46. Supercritical fluid-assisted controllable fabrication of open and highly interconnected porous scaffolds for bone tissue engineering

    Science China Life Sciences · 2019-04-16

    Hanxiao Tang, Ranjith Kumar Kankala, Shi‐Bin Wang, Ai‐Zheng Chen

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  47. Effective encapsulation of curcumin in nanoparticles enabled by hydrogen bonding using flash nanocomplexation

    International Journal of Pharmaceutics · 2019-04-19

    Xiyu Ke, Haoyu Tang, Hai‐Quan Mao

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  48. Meeting the unmet: from traditional to cutting-edge techniques for poly lactide and poly lactide-co-glycolide microparticle manufacturing

    Journal of Pharmaceutical Investigation · 2019-04-29

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  49. Solubility measurement and RESOLV-assisted nanonization of gambogic acid in supercritical carbon dioxide for cancer therapy

    The Journal of Supercritical Fluids · 2019-05-03

    Shu-Ting Xiang, Biao‐Qi Chen, Ranjith Kumar Kankala, Shi‐Bin Wang, Ai‐Zheng Chen

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  50. Highly Porous Microcarriers for Minimally Invasive In Situ Skeletal Muscle Cell Delivery

    Small · 2019-05-08

    Ranjith Kumar Kankala, Jia Zhao, Chenguang Liu, Xiaojie Song, Dayun Yang, Kai Zhu, Shi‐Bin Wang, Yu Shrike Zhang, Ai‐Zheng Chen

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