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RESEARCH PAPER · International Journal of Nanomedicine · 2016

Effects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapy

Xiaodong Zhang, Jie Chen, Junying Wang, Hao Wang, Xiu Shen, Yuanming Sun, Guo Meili, Yang Jiang

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Effects of surface charges of gold nanoclusters on long-term in vivo biodistribution, toxicity, and cancer radiation therapyOriginalEpigallocatechin gallate based magnetic gold nanoshells nanoplatform for cancer theranostic applications15Simple and tunable surface coatings via polydopamine for modulating pharmacokinetics, cell uptake and biodistribution of polymeric nanoparticles43The in vitro and in vivo toxicity of gold nanoparticles315Asialoglycoprotein receptor-targeted liposomes loaded with a norcantharimide derivative for hepatocyte-selective targeting38Recent advances in biomedical applications of fluorescent gold nanoclusters241Enhanced Radiation Therapy of Gold Nanoparticles in Liver Cancer31Black Phosphorus Quantum Dot Induced Oxidative Stress and Toxicity in Living Cells and Mice185Exposure to Inorganic Nanoparticles: Routes of Entry, Immune Response, Biodistribution and In Vitro/In Vivo Toxicity Evaluation362Biological safety and tissue distribution of (16-mercaptohexadecyl)trimethylammonium bromide-modified cationic gold nanorods29Fluorescence enhancement of gold nanoclusters via Zn doping for biomedical applications10Toxicity Assessment in the Nanoparticle Era83Glutathione-Stabilized Fluorescent Gold Nanoclusters Vary in Their Influences on the Proliferation of Pseudorabies Virus and Porcine Reproductive and Respiratory Syndrome Virus44Biodistribution, Clearance, and Long‐Term Fate of Clinically Relevant Nanomaterials461Hollow PtPdRh Nanocubes with Enhanced Catalytic Activities for In Vivo Clearance of Radiation‐Induced ROS via Surface‐Mediated Bond Breaking65miRNAs in Tuberculosis: New Avenues for Diagnosis and Host-Directed Therapy103Porous Nanogold/Polyurethane Scaffolds with Improved Antibiofilm, Mechanical, and Thermal Properties and with Reduced Effects on Cell Viability: A Suitable Material for Soft Tissue Applications29Unintended effects of drug carriers: Big issues of small particles76Preparation of PGA–PAE-Micelles for Enhanced Antitumor Efficacy of Cisplatin27Spherical neutral gold nanoparticles improve anti-inflammatory response, oxidative stress and fibrosis in alcohol-methamphetamine-induced liver injury in rats83Probing the biological obstacles of nanomedicine with gold nanoparticles66Gold nanoparticles-induced cytotoxicity in triple negative breast cancer involves different epigenetic alterations depending upon the surface charge135Biodistribution, Excretion, and Toxicity of Inorganic Nanoparticles13Recent advances in ultra-small fluorescent Au nanoclusters toward oncological research65Gold nanoparticles application in liver cancer87Organotypic and primary neural cultures as models to assess effects of different gold nanostructures on glia and neurons18Synthesis of water-soluble fluorescent gold nanoclusters0Gold nanoparticles affect the antioxidant status in selected normal human cells45Toxicological Behavior of Gold Nanoparticles on Various Models: Influence of Physicochemical Properties and Other Factors184Dual-modal non-invasive imaging in vitro and in vivo monitoring degradation of PLGA scaffold based gold nanoclusters14A Metabolomic Approach for the In Vivo Study of Gold Nanospheres and Nanostars after a Single-Dose Intravenous Administration to Wistar Rats22Complexes de métal-bis(dithiolène) pour la théranostique du cancer : thérapie photothermique, délivrance photocontrôlée de principes actifs et propriétés photoacoustiques0Gold nanoclusters for biomedical applications: toward in vivo studies136Role of inorganic nanoparticle degradation in cancer therapy52Effects of Cetyltrimethylammonium Bromide on the Toxicity of Gold Nanorods Both In Vitro and In Vivo: Molecular Origin of Cytotoxicity and Inflammation86Laser enhancement of cancer cell destruction by photothermal therapy conjugated glutathione (GSH)-coated small-sized gold nanoparticles22In Vivo Pharmacokinetics, Biodistribution and Toxicity of Antibody-Conjugated Gold Nanoparticles in Healthy Mice22Size-Dependent Interactions of Lipid-Coated Gold Nanoparticles: Developing a Better Mechanistic Understanding Through Model Cell Membranes and in vivo Toxicity51Antimicrobial Gold Nanoclusters Eradicate Escherichia coli Biofilms and Are Nontoxic by Oral Administration13Trastuzumab and folic acid functionalized gold nanoclusters as a dual-targeted radiosensitizer for megavoltage radiation therapy of human breast cancer40Mass Balance Study of the Engineered Cationic Antimicrobial Peptide, WLBU2, Following a Single Intravenous Dose of 14C-WLBU2 in Mice1Human Nontumorigenic Microglia Synthesize Strongly Fluorescent Au/Fe Nanoclusters, Retaining Bioavailability5Photothermal therapy of cancer cells enhanced by glutathione (GSH) modified small-sized gold nanoparticles6In Vitro and In Vivo Evaluation of SP94 Modified Liposomes Loaded with N-14NCTDA, a Norcantharimide Derivative for Hepatocellular Carcinoma-Targeting8Physical properties of nanoparticles do matter102A review on nanotoxicity and nanogenotoxicity of different shapes of nanomaterials93Addressing the challenges to increase the efficiency of translating nanomedicine formulations to patients19Cellular uptake and toxicity of gold nanoparticles on two distinct hepatic cell models53Synergistic integration of metal nanoclusters and biomolecules as hybrid systems for therapeutic applications41Gold nanoparticles as a drug delivery system for standard chemotherapeutics: A new lead for targeted pharmacological cancer treatments138Nanomaterials and Human Health3Recent advances in bionanomaterials for liver cancer diagnosis and treatment34Self-assembled anionic and cationic Au nanoparticles with Au nanoclusters for the exploration of different biological responsiveness in cancer therapy14Can nanomaterials induce reproductive toxicity in male mammals? A historical and critical review29Catalytic nanozymes for central nervous system disease66pH/ATP cascade-responsive nano-courier with efficient tumor targeting and siRNA unloading for photothermal-immunotherapy70Biocompatible nucleus-targeted graphene quantum dots for selective killing of cancer cells via DNA damage106The surface-dependent biological effect of protein-gold nanoclusters on human immune system mimetic cells10Gold Nanoclusters Display Low Immunogenic Effect in Microglia Cells11The Role of Gold Nanoclusters as Emerging Theranostic Agents for Cancer Management11Genotoxicity and oxidative stress induction by polystyrene nanoparticles in the colorectal cancer cell line HCT11655Conjugation of curcumin with Ag nanoparticle for improving its bioavailability and study of the bioimaging response3Comparative Toxicity, Biodistribution and Excretion of Ultra-Small Gold Nanoclusters with Different Emission Wavelengths5Gold Nanoclusters as Emerging Theranostic Interventions for Biomedical Applications1Bioavailability, biodistribution, and toxicity of fluorescent metal nanoclusters3Photoluminescent nanocluster-based probes for bioimaging applications20Gold nanoclusters eliminate obesity induced by antipsychotics7Metal Nanoclusters as Biomaterials for Bioapplications: Atomic Precision as the Next Goal77Lotus Seedpod-Inspired Crosslinking-Assembled Hydrogels Based on Gold Nanoclusters for Synergistic Osteosarcoma Multimode Imaging and Therapy32NIR-Ⅱ window Triple-mode antibacterial Nanoplatform: Cationic Copper sulfide nanoparticles combined vancomycin for synergistic bacteria eradication30Engineering Liganded Gold Nanoclusters as Efficient Theranostic Agents for Cancer Applications19Anti-amyloid nanoclusters for the treatment of brain hazards associated with incurable neurodegenerative diseases4Impact of Nanoparticles on Male Fertility: What Do We Really Know? A Systematic Review29Biological Safety and Cellular Interactions of Nanoparticles3Biomolecule-protected gold nanoclusters: synthesis and biomedical applications46Immunotoxicity of metal and metal oxide nanoparticles: from toxic mechanisms to metabolism and outcomes142Preclinical safety assessment of photoluminescent metal quantum clusters stabilized with autologous serum proteins for host specific theranostics4Exploration of surface chemistry effects on the biodistribution and pharmacokinetics of dual-ligand luminescent gold nanoparticles4Therapeutic potential of nanotechnology in reproduction disorders and possible limitations11Methods for Radiolabeling Nanoparticles (Part 3): Therapeutic Use11Atomic Precise Gold Nanoclusters: Toward the Customize Synthesis, Precision Medicine9Investigating the Effect of Surface Hydrophilicity on the Destiny of PLGA-Poloxamer Nanoparticles in an In Vivo Animal Model12Multiscale Bioresponses of Metal Nanoclusters43Nanomaterials for Anti-Infection in Orthopedic Implants: A Review18Targeting the organelle for radiosensitization in cancer radiotherapy20Heteroatom Doping Promoted Ultrabright and Ultrastable Photoluminescence of Water-Soluble Au/Ag Nanoclusters for Visual and Efficient Drug Delivery to Cancer Cells11Design and development of locust bean gum-endowed/Phyllanthus reticulatus anthocyanin- functionalized biogenic gold nanosystem for enhanced antioxidative and anticancer chemotherapy14Pharmacokinetics and toxicity of inorganic nanoparticles and the physicochemical properties/factors affecting them31Unlocking the potential of gold nanoparticles as a game-changer in the fight against hepatocellular carcinoma2Metal Nanoclusters for Cancer Imaging and Treatment17Analysis of Hepatoprotective Activity of Isoquinoline Alkaloids (F-5, F-24), and their Derivatives (KV-6, KV-8) in CCl4-Induced Hepatotoxity in Mice0Gold nanoclusters - A promising atomically precise atomic aggregation-based drug and its biomedical applications6Going for “gold”: Ultra-small gold nanoclusters for autoimmune therapy0

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  1. Epigallocatechin gallate based magnetic gold nanoshells nanoplatform for cancer theranostic applications

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  2. Simple and tunable surface coatings via polydopamine for modulating pharmacokinetics, cell uptake and biodistribution of polymeric nanoparticles

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  3. The in vitro and in vivo toxicity of gold nanoparticles

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  4. Asialoglycoprotein receptor-targeted liposomes loaded with a norcantharimide derivative for hepatocyte-selective targeting

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  5. Recent advances in biomedical applications of fluorescent gold nanoclusters

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  6. Enhanced Radiation Therapy of Gold Nanoparticles in Liver Cancer

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  7. Black Phosphorus Quantum Dot Induced Oxidative Stress and Toxicity in Living Cells and Mice

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  8. Exposure to Inorganic Nanoparticles: Routes of Entry, Immune Response, Biodistribution and In Vitro/In Vivo Toxicity Evaluation

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  9. Biological safety and tissue distribution of (16-mercaptohexadecyl)trimethylammonium bromide-modified cationic gold nanorods

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  10. Fluorescence enhancement of gold nanoclusters via Zn doping for biomedical applications

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  11. Toxicity Assessment in the Nanoparticle Era

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  12. Glutathione-Stabilized Fluorescent Gold Nanoclusters Vary in Their Influences on the Proliferation of Pseudorabies Virus and Porcine Reproductive and Respiratory Syndrome Virus

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  13. Biodistribution, Clearance, and Long‐Term Fate of Clinically Relevant Nanomaterials

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  14. Hollow PtPdRh Nanocubes with Enhanced Catalytic Activities for In Vivo Clearance of Radiation‐Induced ROS via Surface‐Mediated Bond Breaking

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  15. miRNAs in Tuberculosis: New Avenues for Diagnosis and Host-Directed Therapy

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  16. Porous Nanogold/Polyurethane Scaffolds with Improved Antibiofilm, Mechanical, and Thermal Properties and with Reduced Effects on Cell Viability: A Suitable Material for Soft Tissue Applications

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  17. Unintended effects of drug carriers: Big issues of small particles

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    Hamideh Parhiz, Makan Khoshnejad, Jacob W. Myerson, Elizabeth D. Hood, Priyal Patel, Jacob S. Brenner, Vladimir R. Muzykantov

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  18. Preparation of PGA–PAE-Micelles for Enhanced Antitumor Efficacy of Cisplatin

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  19. Spherical neutral gold nanoparticles improve anti-inflammatory response, oxidative stress and fibrosis in alcohol-methamphetamine-induced liver injury in rats

    International Journal of Pharmaceutics · 2018-06-07

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  20. Probing the biological obstacles of nanomedicine with gold nanoparticles

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  21. Gold nanoparticles-induced cytotoxicity in triple negative breast cancer involves different epigenetic alterations depending upon the surface charge

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  22. Biodistribution, Excretion, and Toxicity of Inorganic Nanoparticles

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  23. Recent advances in ultra-small fluorescent Au nanoclusters toward oncological research

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  26. Synthesis of water-soluble fluorescent gold nanoclusters

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  27. Gold nanoparticles affect the antioxidant status in selected normal human cells

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  30. A Metabolomic Approach for the In Vivo Study of Gold Nanospheres and Nanostars after a Single-Dose Intravenous Administration to Wistar Rats

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  32. Gold nanoclusters for biomedical applications: toward in vivo studies

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  33. Role of inorganic nanoparticle degradation in cancer therapy

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  34. Effects of Cetyltrimethylammonium Bromide on the Toxicity of Gold Nanorods Both In Vitro and In Vivo: Molecular Origin of Cytotoxicity and Inflammation

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  35. Laser enhancement of cancer cell destruction by photothermal therapy conjugated glutathione (GSH)-coated small-sized gold nanoparticles

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  36. In Vivo Pharmacokinetics, Biodistribution and Toxicity of Antibody-Conjugated Gold Nanoparticles in Healthy Mice

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  37. Size-Dependent Interactions of Lipid-Coated Gold Nanoparticles: Developing a Better Mechanistic Understanding Through Model Cell Membranes and in vivo Toxicity

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  39. Trastuzumab and folic acid functionalized gold nanoclusters as a dual-targeted radiosensitizer for megavoltage radiation therapy of human breast cancer

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