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RESEARCH PAPER · Scientific Reports · 2016

Accessing the biocompatibility of layered double hydroxide by intramuscular implantation: histological and microcirculation evaluation

Vanessa R. R. Cunha, Rodrigo Barbosa de Souza, Ana Maria Cristina Rebello Pinto da Fonseca Martins, Ivan Hong Jun Koh, Vera Regina Leopoldo Constantino

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Accessing the biocompatibility of layered double hydroxide by intramuscular implantation: histological and microcirculation evaluationOriginalHierarchical self-supported ZnAlEu LDH nanotubes hosting luminescent CdTe quantum dots27Materiais à base de hidróxidos duplos lamelares de cobalto e alumínio: intercalação, reatividade e formação de compósitos por pirólise1Release behavior and signaling effect of vitamin D3 in layered double hydroxides-hydroxyapatite/gelatin bone tissue engineering scaffold: An in vitro evaluation60Tailoring Hybrid Layered Double Hydroxides for the Development of Innovative Applications320Mg–Al and Zn–Al Layered Double Hydroxides Promote Dynamic Expression of Marker Genes in Osteogenic Differentiation by Modulating Mitogen‐Activated Protein Kinases71In vitro biocompatibility analysis of functionalized poly(vinyl chloride)/layered double hydroxide nanocomposites44Layered gadolinium hydroxides for simultaneous drug delivery and imaging44Advanced Inorganic Nanosystems for Skin Drug Delivery53Anti-ulcerant kynurenic acid molecules intercalated Mg/Al-layered double hydroxide and its release study22Layered Double Hydroxides Nanomaterials in Biomedicine and (bio) Sensing Design20Interactions between Biological Cells and Layered Double Hydroxides: Towards Functional Materials64Clay Nanoparticles Elicit Long‐Term Immune Responses by Forming Biodegradable Depots for Sustained Antigen Stimulation77Thermo-physical properties of Cu-Zn-Al LDH nanofluid and its application in spray cooling80A molecular dynamics framework to explore the structure and dynamics of layered double hydroxides45Caffeic Acid-layered Double Hydroxide Hybrid: A New Raw Material for Cosmetic Applications31Analgesic molecules interleaved between layered double hydroxide: Exchange versus in situ reaction and release properties6Stability of Calcium–Alumino Layered-Double-Hydroxide Nanocomposites in Aqueous Electrolytes82D materials for next generation healthcare applications122Synthesis and catalytic activity of Mo(II) complexes of α-diimines intercalated in layered double hydroxides14Clay nanoparticles co-deliver three antigens to promote potent immune responses against pathogenic Escherichia coli41Sonic hedgehog drives layered double hydroxides-induced acute inflammatory landscape12Iron-Based Layered Double Hydroxide Implants: Potential Drug Delivery Carriers with Tissue Biointegration Promotion and Blood Microcirculation Preservation48Layered Double Hydroxide-Decorated Hydrogel for Biomedical Applications2Degradability and Clearance of Inorganic Nanoparticles for Biomedical Applications436Layered double hydroxides and their composites : design, synthesis and specific applications0Crystal Chemistry of Chlormagaluminite, Mg4Al2(OH)12Cl2(H2O)2, a Natural Layered Double Hydroxide24Layered Double Hydroxides Are Promising Nanomaterials for Tissue Bioengineering Application25High-Power Ultrasonic Synthesis and Magnetic-Field-Assisted Arrangement of Nanosized Crystallites of Cobalt-Containing Layered Double Hydroxides10Transition metal substitution effects in sol-gel derived Mg3-xMx/Al1 (M = Mn, Co, Ni, Cu, Zn) layered double hydroxides33Layered Double Hydroxides: A Toolbox for Chemistry and Biology156Hybrid systems of glibenclamide and layered double hydroxides for solubility enhancement for the treatment of diabetes mellitus II23Hidróxidos duplos lamelares: estudos da intercalação e liberação de N-acetil-L-cisteína0Sol–Gel Synthesis and Characterization of Coatings of Mg-Al Layered Double Hydroxides39An in vitro comparative study of layered-double hydroxide nanoconjugate in the delivery of small interference and short-hairpin ribonucleic acid6Methods for synthesis of nanocontainers3Phytochemical species intercalated into layered double hydroxides: structural investigation and biocompatibility assays13Structural arrangement and properties of layered double hydroxide drug nanocarrier intercalated by sulindac and mefenamic acid solved by molecular simulation methods24Acrylic acid grafted gelatin/LDH based biocompatible hydrogel with pH-controllable release of vitamin B1236Design of 3D multi-layered electrospun membranes embedding iron-based layered double hydroxide for drug storage and control of sustained release29One-pot synthesis of the organomodified layered double hydroxides - glibenclamide biocompatible nanoparticles242D Layered Double Hydroxides52D nanomaterials for tissue engineering application90Antibacterial nanomaterials for environmental and consumer product applications673D additive manufactured composite scaffolds with antibiotic-loaded lamellar fillers for bone infection prevention and tissue regeneration68Fabrication of Hollow LDH nanocages using ZIF-67 template as superb adsorbent for anionic organic pollutant20Polymer/Iron-Based Layered Double Hydroxides as Multifunctional Wound Dressings17Advanced drug delivery applications of layered double hydroxide306Layered double hydroxide-based nanocomposite scaffolds in tissue engineering applications43Synthesis of new layered double hydroxides, modification and investigation of properties0Exfoliation of carboxymethylcellulose-intercalated layered double hydroxide in water9Transparent and Unipolar Nonvolatile Memory Using 2D Vertically Stacked Layered Double Hydroxide3Emerging 2D nanomaterials for biomedical applications349Novel Anti-Inflammatory and Wound Healing Controlled Released LDH-Curcumin Nanocomposite Via Intramuscular Implantation, In-Vivo Study0Hierarchical Two-Dimensional Layered Double Hydroxide Coated Polydopamine Nanocarriers for Combined Chemodynamic and Photothermal Tumor Therapy10Material híbrido orgânico-inorgânico de apocarotenoide natural e hidróxido duplo lamelar como emulsificante de pickering0Bionanocomposite Beads Based on Montmorillonite and Biopolymers as Potential Systems for Oral Release of Ciprofloxacin10Ce-substituted Mg-Al layered double hydroxides to prolong the corrosion protection lifetime of aluminium alloys31Ciprofloxacin in Layered Double Hydroxides: Looking for the Best Synthesis Method3Hydrophilic lycopene-coated layered double hydroxide nanoparticles to enhance the antioxidant activity and the oxidative stress evaluation7Inorganic Materials in Drug Delivery1Innovative membrane containing iron-based layered double hydroxide intercalated with phyto therapeutic diterpenoid4Novel anti-inflammatory and wound healing controlled released LDH-Curcumin nanocomposite via intramuscular implantation, in-vivo study30Fe(III)‐Based Layered Double Hydroxides Carrying Model Naproxenate Anions: Compositional and Structural Aspects4Nanoscale layered double hydroxide modified hybrid nanomaterials for wastewater treatment: A review64Overcoming Antibiotic Resistance: Playing the ‘Silver Nanobullet’ Card2Computational Indicator Approach for Assessment of Nanotoxicity of Two-Dimensional Nanomaterials29Two-dimensional (2D) hybrid nanomaterials for diagnosis and treatment of cancer28Layered double hydroxide applications in biomedical implants28Anti-Inflammatory and Analgesic Evaluation of a Phytochemical Intercalated into Layered Double Hydroxide13Size and surface charge effect of layered double hydroxide particles upon blood cells11Limiting content of trivalent iron to form organic-inorganic single-phase layered double hydroxides hybrids by coprecipitation7Bio-Inorganic Layered Double Hydroxide Nanohybrids in Photochemotherapy: A Mini Review18Surface modification of two-dimensional layered double hydroxide nanoparticles with biopolymers for biomedical applications87Layered Double Hydroxides (LDH) as nanocarriers for antimicrobial chemotherapy: From formulation to targeted applications22Biomaterials Based on Organic Polymers and Layered Double Hydroxides Nanocomposites: Drug Delivery and Tissue Engineering73Efficacy and safety of nanoparticles of glibenclamide and organomodified layered double hydroxides in diabetics rats5Development of Dipeptide N–acetyl–L–cysteine Loaded Nanostructured Carriers Based on Inorganic Layered Hydroxides4Estudo de processo inflamatório articular por espectroscopia Raman: ação de compostos lamelares e detecção de alterações fisiológicas0Structural and Photoprotective Characteristics of Zn-Ti, Zn-Al, and Mg-Al Layered Double Hydroxides—A Comparative Study9Biomedical relevant layered double hydroxides as versatile drug carriers and nanofillers1Layered double hydroxides and their tailored hybrids/composites: Progressive trends for delivery of natural/synthetic-drug/cosmetic biomolecules44Layered Double Hydroxides as an Intercalation System for Hydrophobic Molecules15Applications of LDHs to Biomedicine: State of the Art and Future Challenges0Development of polysaccharide-coated layered double hydroxide nanocomposites for enhanced oral insulin delivery21Layered double hydroxides (LDHs) as efficient and safe carriers for miRNA inhibitors: In vitro and in vivo assessment of biocompatibility9Layered Double Hydroxides: Recent Progress and Promising Perspectives Toward Biomedical Applications136Injectable Thermogelling Nanostructured Ink as Simultaneous Optical and Magnetic Resonance Imaging Contrast Agent for Image-Guided Surgery1Valproate intercalated in layered double hydroxides: Synthesis, characterization, release kinetics and biocompatibility studies6Layered Double Hydroxides (LDH) as Delivery Vehicles of a Chimeric Protein Carrying Epitopes from the Porcine Reproductive and Respiratory Syndrome Virus6Mechanisms of Metal Ion-Mediated “Inflammation-Repair” Dynamic Regulatory Network and Related Biomimetic Material Design Strategies0Starch in drug delivery1Advances in application of layered double hydroxide/polymer nanocomposites for bone tissue engineering1Powering the heart: fully bioresorbable epicardial pacing leads1Layered double hydroxides based nanomaterials: recent advances in drug delivery and biomedical applications7Layered zinc hydroxide–dipeptide hybrid integrated into silk-based 3D scaffolds aiming for biomedical applications1Transition Metal Layered Double Hydroxides as Emerging Platforms for Biomedical Applications0Investigation of biological pathway of cobalt-55-labeled layered double hydroxide depending on surface charge0Functionalized Layered Double Hydroxides for Drug Delivery0Structured Layered Double Hydroxide-Based Catalysts for Process Intensification: Transport, Stability, and Scale-Up in Monoliths, Foams, Films, and Washcoats0Development of 5-fluorouracil-intercalated Mg–Al LDH nanohybrids for the targeted growth inhibition of cervical cancer0

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  1. Hierarchical self-supported ZnAlEu LDH nanotubes hosting luminescent CdTe quantum dots

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  2. Materiais à base de hidróxidos duplos lamelares de cobalto e alumínio: intercalação, reatividade e formação de compósitos por pirólise

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  3. Release behavior and signaling effect of vitamin D3 in layered double hydroxides-hydroxyapatite/gelatin bone tissue engineering scaffold: An in vitro evaluation

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  4. Tailoring Hybrid Layered Double Hydroxides for the Development of Innovative Applications

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  5. Mg–Al and Zn–Al Layered Double Hydroxides Promote Dynamic Expression of Marker Genes in Osteogenic Differentiation by Modulating Mitogen‐Activated Protein Kinases

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  6. In vitro biocompatibility analysis of functionalized poly(vinyl chloride)/layered double hydroxide nanocomposites

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  7. Layered gadolinium hydroxides for simultaneous drug delivery and imaging

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  9. Anti-ulcerant kynurenic acid molecules intercalated Mg/Al-layered double hydroxide and its release study

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  10. Layered Double Hydroxides Nanomaterials in Biomedicine and (bio) Sensing Design

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  14. A molecular dynamics framework to explore the structure and dynamics of layered double hydroxides

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  15. Caffeic Acid-layered Double Hydroxide Hybrid: A New Raw Material for Cosmetic Applications

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  16. Analgesic molecules interleaved between layered double hydroxide: Exchange versus in situ reaction and release properties

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  17. Stability of Calcium–Alumino Layered-Double-Hydroxide Nanocomposites in Aqueous Electrolytes

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  18. 2D materials for next generation healthcare applications

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  19. Synthesis and catalytic activity of Mo(II) complexes of α-diimines intercalated in layered double hydroxides

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  20. Clay nanoparticles co-deliver three antigens to promote potent immune responses against pathogenic Escherichia coli

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  21. Sonic hedgehog drives layered double hydroxides-induced acute inflammatory landscape

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  22. Iron-Based Layered Double Hydroxide Implants: Potential Drug Delivery Carriers with Tissue Biointegration Promotion and Blood Microcirculation Preservation

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  23. Layered Double Hydroxide-Decorated Hydrogel for Biomedical Applications

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  24. Degradability and Clearance of Inorganic Nanoparticles for Biomedical Applications

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  31. Hybrid systems of glibenclamide and layered double hydroxides for solubility enhancement for the treatment of diabetes mellitus II

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  32. Hidróxidos duplos lamelares: estudos da intercalação e liberação de N-acetil-L-cisteína

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  33. Sol–Gel Synthesis and Characterization of Coatings of Mg-Al Layered Double Hydroxides

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  34. An in vitro comparative study of layered-double hydroxide nanoconjugate in the delivery of small interference and short-hairpin ribonucleic acid

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  36. Phytochemical species intercalated into layered double hydroxides: structural investigation and biocompatibility assays

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  37. Structural arrangement and properties of layered double hydroxide drug nanocarrier intercalated by sulindac and mefenamic acid solved by molecular simulation methods

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  48. Layered double hydroxide-based nanocomposite scaffolds in tissue engineering applications

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  49. Synthesis of new layered double hydroxides, modification and investigation of properties

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  50. Exfoliation of carboxymethylcellulose-intercalated layered double hydroxide in water

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