RESEARCH ARTICLE · Communication on Contemporary Anthropology · 2010

Three Revolutionary Changes in the Development of Ancient DNA Analysis Techniques

Chuanchao WANG, Hui Li

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Abstract

Ancient DNA (aDNA) is the DNA recovered from post mortem archaeological or historical specimens. With the widespread adoption of molecular biological techniques over the past two decades, the study of aDNA has evolved from the retrieval of small fragments of mitochondrial DNA of extinct species to entire genome sequencing of Neanderthals. These techniques, including molecular cloning, polymerase chain reaction (PCR), next generation DNA sequencing techniques, primer extension capture (PEC), and array hybridization capture, have solved numerous cases that had been mysteries for thousands of years.

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