RESEARCH ARTICLE · Nucleic Acids Research · 2010

The UCSC Genome Browser database: update 2011

Pauline A. Fujita, Brooke L. Rhead, Ann S. Zweig, Angie S. Hinrichs, Donna Karolchik, Melissa Cline, Mary J. Goldman, G. P. Barber, Hiram Clawson, A. Coelho, Mark Diekhans, Timothy R. Dreszer, Belinda M. Giardine, Rachel Harte, Jennifer Hillman‐Jackson, F. Hsu, Vanessa M. Kirkup, Robert M. Kuhn, Katrina Learned, Chunhao Li, Laurence R. Meyer, Andrew A. Pohl, Brian J. Raney, Kate R. Rosenbloom, Kayla E. Smith, David H. Haussler, William James Kent

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Abstract

The University of California, Santa Cruz Genome Browser (http://genome.ucsc.edu) offers online access to a database of genomic sequence and annotation data for a wide variety of organisms. The Browser also has many tools for visualizing, comparing and analyzing both publicly available and user-generated genomic data sets, aligning sequences and uploading user data. Among the features released this year are a gene search tool and annotation track drag-reorder functionality as well as support for BAM and BigWig/BigBed file formats. New display enhancements include overlay of multiple wiggle tracks through use of transparent coloring, options for displaying transformed wiggle data, a 'mean+whiskers' windowing function for display of wiggle data at high zoom levels, and more color schemes for microarray data. New data highlights include seven new genome assemblies, a Neandertal genome data portal, phenotype and disease association data, a human RNA editing track, and a zebrafish Conservation track. We also describe updates to existing tracks.

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