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RESEARCH PAPER · Proceedings of the National Academy of Sciences · 2008

Time-resolved and two-photon emission imaging microscopy of live cells with inert platinum complexes

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Time-resolved and two-photon emission imaging microscopy of live cells with inert platinum complexesOriginalSome Factors Influencing the Losses of Pigs Prior to Weaning.7Photophysical properties of metal complexes10An intensely and oxygen independent phosphorescent gold(i)–silver(i) complex: “trapping” an Au8Ag10 oligomer by two gold-alkynyl-diphosphine molecules61Cytotoxicity, cellular localisation and biomolecular interaction of non-covalent metallo-intercalators with appended sex hormone steroid vectors39Long-life fluorescent imaging of cells in real time0Photophysical properties of metal complexes2Responsive and reactive terbium complexes with an azaxanthone sensitiser and one naphthyl group: applications in ratiometric oxygen sensing in vitro and in regioselective cell killing125The coordination chemistry of dipyridylbenzene: N-deficient terpyridine or panacea for brightly luminescent metal complexes?321The mechanism of cell uptake for luminescent lanthanide optical probes: the role of macropinocytosis and the effect of enhanced membrane permeability on compartmentalisation56A Bioaccumulative Cyclometalated Platinum(II) Complex with Two-Photon-Induced Emission for Live Cell Imaging101Cyclometalated Platinum(II) Complexes as Highly Sensitive Luminescent Switch‐On Probes for Practical Application in Protein Staining and Cell Imaging146Near-Infrared Phosphorescent Polymeric Nanomicelles: Efficient Optical Probes for Tumor Imaging and Detection92Two-Photon Plasma Membrane Imaging in Live Cells by an Amphiphilic, Water-Soluble Cyctometalated Platinum(II) Complex66Studies of Two-Photon Property of Intensely Luminescent Alkynyl−Phosphine Gold(I)−Copper(I) Complexes17Luminescent Platinum Compounds: From Molecules to OLEDs127Application of Metal Coordination Chemistry To Explore and Manipulate Cell Biology984A ruthenium(II) polypyridyl complex for direct imaging of DNA structure in living cells485Probing the Excited State Properties of the Highly Phosphorescent Pt(dpyb)Cl Compound by High-Resolution Optical Spectroscopy78Whole-body, real-time preclinical imaging of quantum dot fluorescence with time-gated detection32Development of responsive lanthanide probes for cellular applications273Application of d6 transition metal complexes in fluorescence cell imaging753Luminescent Platinum Complexes with Terdentate Ligands Forming 6-Membered Chelate Rings: Advantageous and Deleterious Effects in N∧N∧N and N∧C∧N-Coordinated Complexes865-(Dimethylamino)-N-(4-ethynylphenyl)-1-naphthalenesulfonamide as a novel bifunctional antitumor agent and two-photon induced bio-imaging probe23Gold(iii) six-membered N⁁C⁁N pincer complexes: synthesis, structure, reactivity and theoretical calculations26Luminescent conjugates between dinuclear rhenium(i) complexes and peptide nucleic acids (PNA) for cell imaging and DNA targeting88Observation of the selective staining of chromosomal DNA in dividing cells using a luminescent terbium(iii) complex58Rational reductive fusion of two heterometallic clusters: formation of a highly stable, intensely phosphorescent Au–Ag aggregate and application in two-photon imaging in human mesenchymal stem cells48The time domain in co-stained cell imaging: time-resolved emission imaging microscopy using a protonatable luminescent iridium complex167Two-photon luminescence from polar bis-terpyridyl-stilbene derivatives of Ir(iii) and Ru(ii)68Structure, Photophysical and Electrochemical Properties, Biomolecular Interactions, and Intracellular Uptake of Luminescent Cyclometalated Iridium(III) Dipyridoquinoxaline Complexes149A Triphenylphosphonium‐Functionalised Cyclometalated Platinum(II) Complex as a Nucleolus‐Specific Two‐Photon Molecular Dye70Site‐Selective Ser‐Hydrolase Labelling with a Luminescent Organometallic NCN–Platinum Complex30Highly Luminescent Tetradentate Bis-Cyclometalated Platinum Complexes: Design, Synthesis, Structure, Photophysics, and Electroluminescence Application255Conjugated Oligoelectrolyte Harnessed Polyhedral Oligomeric Silsesquioxane as Light‐Up Hybrid Nanodot for Two‐Photon Fluorescence Imaging of Cellular Nucleus100Modification of Luminescent Iridium(III) Polypyridine Complexes with Discrete Poly(ethylene glycol) (PEG) Pendants: Synthesis, Emissive Behavior, Intracellular Uptake, and PEGylation Properties107Time-resolved luminescence resonance energy transfer imaging of protein–protein interactions in living cells152Luminescent cyclometallated iridium( iii ) bis(quinolylbenzaldehyde) diimine complexes—synthesis, photophysics, electrochemistry, protein cross-linking properties, cytotoxicity and cellular uptake80Improvement in Phosphorescence Efficiency through Tuning of Coordination Geometry of Tridentate Cyclometalated Platinum(II) Complexes73Time‐resolved microscopy for imaging lanthanide luminescence in living cells84The Triplet State of fac-Ir(ppy)3410Enhancing magnetic resonance imaging tumor detection with fluorescence intensity and lifetime imaging5Congested Cyclometalated Platinum(II) Ditopic Frameworks and Their Phosphorescent Responses to S-Containing Amino Acids19Photophysics of transition metal complexes4Photon arrival timing with sub-camera exposure time resolution in wide-field time-resolved photon counting imaging18Rapid wide-field photon counting imaging with microsecond time resolution28Solvent-controlled switch of selectivity between sp 2 and sp 3 C–H bond activation by platinum( ii )32Luminescent zinc salen complexes as single and two-photon fluorescence subcellular imaging probes122A ‘Sleeping Trojan Horse’ which transports metal ions into cells, localises in nucleoli, and has potential for bimodal fluorescence/PET imaging51Amino-anthraquinone chromophores functionalised with 3-picolyl units: structures, luminescence, DFT and their coordination chemistry with cationic Re(i) di-imine complexes23Background-free Cytometry Using Rare Earth Complex Bioprobes11Complexes in context: Attempting to control the cellular uptake and localisation of rhenium fac-tricarbonyl polypyridyl complexes99Cyclometallated platinum(ii) complexes of 1,3-di(2-pyridyl)benzenes: tuning excimer emission from red to near-infrared for NIR-OLEDs117Cytotoxic activity, cell imaging and photocleavage of DNA induced by a Pt(ii) cyclophane bearing 1,2 diamino ethane as a terminal ligand27Fluorescent gallium and indium bis(thiosemicarbazonates) and their radiolabelled analogues: Synthesis, structures and cellular confocal fluorescence imaging investigations64Luminescent square-planar platinum(ii) complexes with tridentate 3-bis(2-pyridylimino)isoindoline and monodentate N-heterocyclic ligands26Phosphorescent heavy-metal complexes for bioimaging1260Phosphorescent platinum(ii) complexes containing different β-diketonate ligands: synthesis, tunable excited-state properties, and their application in bioimaging65Polymer nanoparticles with an embedded phosphorescent osmium(ii) complex for cell imaging28Studies of the isomerization and photophysical properties of a novel 2,2′:6′,2′′-terpyridine-based ligand and its complexes32Two-photon spectroscopy of cyclometalated iridium complexes54Water-soluble phosphorescent iridium(iii) complexes as multicolor probes for imaging of homocysteine and cysteine in living cells114The triplet state of organo-transition metal compounds. Triplet harvesting and singlet harvesting for efficient OLEDs1334Time-Gated Luminescence Microscopy Allowing Direct Visual Inspection of Lanthanide-Stained Microorganisms in Background-Free Condition132Critical Design Factors for Optical Imaging with Metal Coordination Complexes38Phosphorescence vs Fluorescence in Cyclometalated Platinum(II) and Iridium(III) Complexes of (Oligo)thienylpyridines226Colloidal Synthesis and Nanocharacterization of Engineered Noble Metal Nanoparticles10Women in Chemistry0Highly Luminescent Mixed-Metal Pt(II)/Ir(III) Complexes: Bis-Cyclometalation of 4,6-Diphenylpyrimidine As a Versatile Route to Rigid Multimetallic Assemblies91A Nonemissive Iridium(III) Complex That Specifically Lights-Up the Nuclei of Living Cells373Ratiometric Phosphorescence Imaging of Hg(II) in Living Cells Based on a Neutral Iridium(III) Complex122Recent Exploitation of Luminescent Rhenium(I) Tricarbonyl Polypyridine Complexes as Biomolecular and Cellular Probes148Assembly and Targeting of Liposomal Nanoparticles Encapsulating Quantum Dots33Highly Luminescent Tridentate N∧C*N Platinum(II) Complexes Featured in Fused Five–Six-Membered Metallacycle and Diminishing Concentration Quenching70Blue-Light Emission of Cu(I) Complexes and Singlet Harvesting466Synthesis, Crystal Structures, Photophysical Properties, and Bioimaging of Living Cells of Bis-β-Diketonate Phenothiazine Ligands and Its Cyclic Dinuclear Complexes39Fluorescent Conjugated Polyelectrolytes for Bioimaging257Ultrabright Eu–Doped Plasmonic Ag@SiO2 Nanostructures: Time‐gated Bioprobes with Single Particle Sensitivity and Negligible Background64Novel Metal-Based Luminophores for Biological Imaging7In Vitro and in Vivo Fluorescent Imaging of a Monofunctional Chelated Platinum Complex Excitable Using Visible Light34Interactions of Metal Ions with DNA, Its Constituents and Derivatives, which may be Relevant for Anticancer Research100Improving the Performance of Pt(II) Complexes for Blue Light Emission by Enhancing the Molecular Rigidity248Interactions Between Amino Acid‐Tagged Naphthalenediimide and Single Walled Carbon Nanotubes for the Design and Construction of New Bioimaging Probes52The synthesis and photophysical studies of cyclometalated Pt( ii ) complexes with C,N,N-ligands containing imidazolyl donors18Assembly, Two-Photon Absorption, and Bioimaging of Living Cells of A Cuprous Cluster67A highly selective sulfur-free iridium(iii)-complex-based phosphorescent chemidosimeter for detection of mercury(ii) ions27A strong two-photon induced phosphorescent Golgi-specific in vitro marker based on a heteroleptic iridium complex90Applications of luminescent inorganic and organometallic transition metal complexes as biomolecular and cellular probes386Combined two-photon excitation and d → f energy-transfer in Ir/lanthanide dyads with time-gated selection from a two-component emission spectrum32Photofunctional triplet excited states of cyclometalated Ir(iii) complexes: beyond electroluminescence668Time-Resolved Luminescence Resonance Energy Transfer Imaging of Protein–Protein Interactions in Living Cells22Encapsulation of hydrophobic pyrenylcycloplatinate complexes within a water-soluble arene ruthenium metallacage22Two-photon excitation with pico-second fluorescence lifetime imaging to detect nuclear association of flavanols13Multifunctional Ligands in Medicinal Inorganic Chemistry- Current Trends and Future Directions25Probing Liquid/Solid Interfaces at the Molecular Level458Phosphorescence Imaging of Living Cells with Amino Acid-Functionalized Tris(2-phenylpyridine)iridium(III) Complexes80Lighting the way to see inside the live cell with luminescent transition metal complexes474Molecular design and theoretical investigation into one- and two-photon absorption properties of two series of cyclometalated platinum (II) complexes0Organometallic Compounds: An Opportunity for Chemical Biology?213Evaluation of two novel methods for assessing intracellular oxygen7Organelle-Specific Detection of Phosphatase Activities with Two-Photon Fluorogenic Probes in Cells and Tissues172Novel phosphorescent tetradentate bis-cyclometalated C^C∗N^N-coordinated platinum complexes: Structure, photophysics, and a synthetic adventure40An Introduction to Organometallic Complexes in Fluorescence Cell Imaging: Current Applications and Future Prospects84Metal Complexes of Pincer Ligands: Excited States, Photochemistry, and Luminescence41Quantification of the Plasma Clearance Kinetics of a Gadolinium-Based Contrast Agent by Photoinduced Triplet Harvesting3Luminescent Transition-Metal Complexes as Biomolecular and Cellular Probes0Two‐Photon‐Activated Ligand Exchange in Platinum(II) Complexes42Two‐Photon‐Activated Ligand Exchange in Platinum(II) Complexes13A water-soluble phosphorescent polymer for time-resolved assay and bioimaging of cysteine/homocysteine69New developments in the biomedical chemistry of metal complexes: from small molecules to nanotheranostic design32The cellular uptake and localization of non-emissive iridium(III) complexes as cellular reaction-based luminescence probes77Luminescent Rhenium and Ruthenium Complexes of an Amphoteric Poly(amidoamine) Functionalized with 1,10-Phenanthroline39Organometallic Emitters for OLEDs: Triplet Harvesting, Singlet Harvesting, Case Structures, and Trends51Synthesis, One‐ and Two‐Photon Photophysical and Excited‐State Properties, and Sensing Application of a New Phosphorescent Dinuclear Cationic Iridium(III) Complex66Rational Design of an “OFF–ON” Phosphorescent Chemodosimeter Based on an Iridium(III) Complex and Its Application for Time‐Resolved Luminescent Detection and Bioimaging of Cysteine and Homocysteine112Chemosensing and Diagnostics6Heteronuclear phosphorescent iridium(iii) complexes with tunable photophysical and excited-state properties by chelating BF2 moiety for application in bioimaging26New avenues in the design and potential application of metal complexes for photodynamic therapy165Solvation Dynamics of Biological Water in a Single Live Cell under a Confocal Microscope57Cationic Polyfluorenes with Phosphorescent Iridium(III) Complexes for Time‐Resolved Luminescent Biosensing and Fluorescence Lifetime Imaging173Phosphorescent Imaging of Living Cells Using a Cyclometalated Iridium(III) Complex39Synthesis, crystal structure and photoluminescence of phosphorescent copper (I) complexes containing hole-transporting carbazoly moiety15A phosphorescent silver(I)–gold (I) cluster complex that specifically lights up the nucleolus of living cells with FLIM imaging66Dynamics in Cytoplasm, Nucleus, and Lipid Droplet of a Live CHO Cell: Time-Resolved Confocal Microscopy48The Cell’s Nucleolus: an Emerging Target for Chemotherapeutic Intervention54Intracellular oxygen: Similar results from two methods of measurement using phosphorescent nanoparticles8Light harvesting properties of some new heteroleptic dithiocarbimate–diamine/diimine complexes of Ni, Pd and Pt studied as photosensitizer in dye-sensitized TiO 2 solar cells23Synthesis, structure and photoluminescence properties of copper(II) and cobalt(III) complexes with pyridoxalaminoguanidine16Synthesis, Structure, Photophysics, and a DFT Study of Phosphorescent C*N∧N- and C∧N∧N-Coordinated Platinum Complexes49Long-lived metal complexes open up microsecond lifetime imaging microscopy under multiphoton excitation: from FLIM to PLIM and beyond195Progress with, and prospects for, metal complexes in cell imaging188Water-soluble noncovalent adducts of the heterometallic copper subgroup complexes and human serum albumin with remarkable luminescent properties20Rational Design of Phosphorescent Chemodosimeter for Reaction‐Based One‐ and Two‐Photon and Time‐Resolved Luminescent Imaging of Biothiols in Living Cells64Luminescent oligo(ethylene glycol)-functionalized cyclometalated platinum(ii) complexes: cellular characterization and mitochondria-specific localization28Folic acid-modified iridium(III) coordination polymeric nanoparticles facilitating intracellular release of a phosphorescent residue capable of nuclear entry13Bio-imaging with neutral luminescent Pt( ii ) complexes showing metal⋯metal interactions69Dinuclear ruthenium(ii) polypyridyl complexes as single and two-photon luminescence cellular imaging probes76Modulation of the organelle specificity in Re( i ) tetrazolato complexes leads to labeling of lipid droplets56Time-Resolved Emission Imaging Microscopy Using Phosphorescent Metal Complexes: Taking FLIM and PLIM to New Lengths50Two-photon phosphorescence lifetime imaging of cells and tissues using a long-lived cyclometallated N pyridyl ^C phenyl ^N pyridyl Pt( ii ) complex42Utilization of the photophysical and photochemical properties of phosphorescent transition metal complexes in the development of photofunctional cellular sensors, imaging reagents, and cytotoxic agents94When self-assembly meets biology: luminescent platinum complexes for imaging applications385Dinuclear Ruthenium(II) Complexes as Two‐Photon, Time‐Resolved Emission Microscopy Probes for Cellular DNA200Dinuclear Ruthenium(II) Complexes as Two‐Photon, Time‐Resolved Emission Microscopy Probes for Cellular DNA30Cytotoxicity of cyclometalated platinum complexes based on tridentate NCN and CNN-coordinating ligands: Remarkable coordination dependence34Chemosensing of Chloride Based on a Luminescent Platinum(II) NCN Pincer Complex in Aqueous Media55Water-Soluble Triscyclometalated Organoiridium Complex: Phosphorescent Nanoparticle Formation, Nonlinear Optics, and Application for Cell Imaging40Fluorescent Rhenium-Naphthalimide Conjugates as Cellular Imaging Agents60Synthesis, Crystal Structures and Photo- and Electro-Luminescence of Copper(I) Complexes Containing Electron-Transporting Diaryl-1,3,4-Oxadiazole12Smart responsive phosphorescent materials for data recording and security protection805Metal Complexes for Cell and Organism Imaging6

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  1. Some Factors Influencing the Losses of Pigs Prior to Weaning.

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  4. Cytotoxicity, cellular localisation and biomolecular interaction of non-covalent metallo-intercalators with appended sex hormone steroid vectors

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  5. Long-life fluorescent imaging of cells in real time

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  7. Responsive and reactive terbium complexes with an azaxanthone sensitiser and one naphthyl group: applications in ratiometric oxygen sensing in vitro and in regioselective cell killing

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  8. The coordination chemistry of dipyridylbenzene: N-deficient terpyridine or panacea for brightly luminescent metal complexes?

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  9. The mechanism of cell uptake for luminescent lanthanide optical probes: the role of macropinocytosis and the effect of enhanced membrane permeability on compartmentalisation

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  11. Cyclometalated Platinum(II) Complexes as Highly Sensitive Luminescent Switch‐On Probes for Practical Application in Protein Staining and Cell Imaging

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  12. Near-Infrared Phosphorescent Polymeric Nanomicelles: Efficient Optical Probes for Tumor Imaging and Detection

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  13. Two-Photon Plasma Membrane Imaging in Live Cells by an Amphiphilic, Water-Soluble Cyctometalated Platinum(II) Complex

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  14. Studies of Two-Photon Property of Intensely Luminescent Alkynyl−Phosphine Gold(I)−Copper(I) Complexes

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  26. Observation of the selective staining of chromosomal DNA in dividing cells using a luminescent terbium(iii) complex

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  29. Two-photon luminescence from polar bis-terpyridyl-stilbene derivatives of Ir(iii) and Ru(ii)

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  33. Highly Luminescent Tetradentate Bis-Cyclometalated Platinum Complexes: Design, Synthesis, Structure, Photophysics, and Electroluminescence Application

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  34. Conjugated Oligoelectrolyte Harnessed Polyhedral Oligomeric Silsesquioxane as Light‐Up Hybrid Nanodot for Two‐Photon Fluorescence Imaging of Cellular Nucleus

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  35. Modification of Luminescent Iridium(III) Polypyridine Complexes with Discrete Poly(ethylene glycol) (PEG) Pendants: Synthesis, Emissive Behavior, Intracellular Uptake, and PEGylation Properties

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  36. Time-resolved luminescence resonance energy transfer imaging of protein–protein interactions in living cells

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  37. Luminescent cyclometallated iridium( iii ) bis(quinolylbenzaldehyde) diimine complexes—synthesis, photophysics, electrochemistry, protein cross-linking properties, cytotoxicity and cellular uptake

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  38. Improvement in Phosphorescence Efficiency through Tuning of Coordination Geometry of Tridentate Cyclometalated Platinum(II) Complexes

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  39. Time‐resolved microscopy for imaging lanthanide luminescence in living cells

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  40. The Triplet State of fac-Ir(ppy)3

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  41. Enhancing magnetic resonance imaging tumor detection with fluorescence intensity and lifetime imaging

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  42. Congested Cyclometalated Platinum(II) Ditopic Frameworks and Their Phosphorescent Responses to S-Containing Amino Acids

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  43. Photophysics of transition metal complexes

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  44. Photon arrival timing with sub-camera exposure time resolution in wide-field time-resolved photon counting imaging

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